Results 141 to 150 of about 38,315 (266)

Advances in Bruton tyrosine kinase (Btk) inhibition are steered by Bruton tyrosine kinase phylogeny

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 7, Page 1446-1451, April 2025.
Abstract Bruton tyrosine kinase (Btk) has long been known to play a key role in chronic lymphatic leukaemia, Waldenström macroglobulinaemia and other B‐cell proliferative disorders. An impressive programme of drug discovery and clinical development led to the approval of covalent and non‐covalent Btk inhibitors that became pillars of treatment of such ...
Giorgio Minotti   +3 more
wiley   +1 more source

Expression of ErbB receptors during pancreatic islet development and regrowth [PDF]

open access: bronze, 2000
MR Kritzik   +6 more
openalex   +1 more source

Binding Selectivity Analysis from Alchemical Receptor Hopping and Swapping Free Energy Calculations [PDF]

open access: yesarXiv
We present receptor hopping and receptor swapping free energy estimation protocols based on the Alchemical Transfer Method (ATM) to model the binding selectivity of a set of ligands to two arbitrary receptors. The receptor hopping protocol, where a ligand is alchemically transferred from one receptor to another in one simulation, directly yields the ...
arxiv  

Expression of c‐erbB receptors, heregulin and oestrogen receptor in human breast cell lines [PDF]

open access: bronze, 2000
Anna deFazio   +4 more
openalex   +1 more source

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