Brazilian Journal of Medical and Biological Research, 2001 There are few data evaluating biological markers for men with breast cancer. The purpose of the present study was to analyze the expression of the oncogenes c-erbB-2 and c-myc and of the suppressor gene p53 by immunohistochemical techniques in archival ...
M. Mourão Netto +4 more
doaj +1 more source
Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization. [PDF]
Mol Biol Res Commun, 2023 Mashayekh-Poul R +2 more
europepmc +1 more source
Antiserum raised against a synthetic phosphotyrosine-containing peptide selectively recognizes p185neu/erbB-2 and the epidermal growth factor receptor. [PDF]
, 1992 Lakshmi Bangalore +3 more
openalex +1 more source
The FEBS Journal, EarlyView.Whole‐organism phosphoproteomics after ErbB inhibitor treatment was assessed in zebrafish embryos. Differential signaling was uncovered after treatments with more selective ErbB inhibitors and pan‐ErbB inhibitors, despite similar neurological and myocardial phenotypes.
Katri Vaparanta +10 more
wiley +1 more source
The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease
Biomarker Insights, 2015 Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function.
Cassady E. Rupert, Kareen L.K. Coulombe
doaj +1 more source
The characterization, management, and future considerations for ErbB-family TKI-associated diarrhea. [PDF]
, 2019 PurposeDiarrhea is recognized as a common adverse event associated with tyrosine kinase inhibitors (TKIs), with those targeting the ErbB family of receptors being associated with the highest rate of diarrhea.MethodsThis paper reviews data on the ...
Bosserman, Linda +6 more
core
Molecular Systems Biology, 2009 The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis.
William W Chen +6 more
doaj +1 more source
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. [PDF]
Cancers (Basel), 2022 Adediran S +9 more
europepmc +1 more source
A Chromosome Inversion Creates a Supergene for Sex and Colour in Lake Malawi Cichlids
Molecular Ecology, EarlyView.ABSTRACT Cichlid fishes have the highest rates of evolutionary turnover of sex chromosomes among vertebrates. Many large structural polymorphisms in the radiation of cichlids in Lake Malawi are associated with sex chromosomes and may also carry adaptive variation.
Kristen A. Behrens +10 more
wiley +1 more source
Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses
Molecular Systems Biology, 2007 Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes ...
Marc R Birtwistle +5 more
doaj +1 more source