Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma [PDF]
Frontiers in Medicine, 2023 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type, has often an aggressive course and is poorly responsive to current therapeutic approaches, so that 5-year survival rates for patients diagnosed with advanced disease is ...
Camilla Palumbo +13 more
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Role of ErbB receptors in cancer cell migration and invasion [PDF]
Frontiers in Pharmacology, 2015 Growth factors mediate their diverse biologic responses (regulation of cellular proliferation, differentiation, migration and survival) by binding to and activating cell-surface receptors with intrinsic protein kinase activity named Receptor Tyrosine ...
Aline eAppert-Collin +4 more
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Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo [PDF]
Journal of Translational Medicine, 2022 Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM.
Roberto Bei +17 more
doaj +4 more sources
Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer [PDF]
Biomedicines, 2023 Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1) and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4) play an essential role in enhancing the proliferation, the migratory ...
Antonio Villalobo
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Genomic alterations of ERBB receptors in cancer: clinical implications. [PDF]
Oncotarget, 2017 The ERBB family of receptor tyrosine kinases has been implicated in carcinogenesis for over three decades with rigorous attention to EGFR and HER2. ERBB receptors, consisting of EGFR, HER2, HER3, and HER4 are part of a complicated signaling network that ...
Mishra R, Hanker AB, Garrett JT.
europepmc +2 more sources
Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells. [PDF]
Sci Rep, 2017 Epithelial ovarian cancer (EOC) is the most lethal gynaecological malignancy worldwide. Development of chemoresistance and peritoneal dissemination of EOC cells are the major reasons for low survival rate.
Momeny M +21 more
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Notch Signal Mediates the Cross-Interaction between M2 Muscarinic Acetylcholine Receptor and Neuregulin/ErbB Pathway: Effects on Schwann Cell Proliferation [PDF]
Biomolecules, 2022 The cross-talk between axon and glial cells during development and in adulthood is mediated by several molecules. Among them are neurotransmitters and their receptors, which are involved in the control of myelinating and non-myelinating glial cell ...
Roberta Piovesana +5 more
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The Single Transmembrane Domains of ErbB Receptors Self-associate in Cell Membranes [PDF]
Journal of Biological Chemistry, 2002 Members of the epidermal growth factor receptor, or ErbB, family of receptor tyrosine kinases have a single transmembrane (TM) α-helix that is usually assumed to play a passive role in ligand-induced dimerization and activation of the receptor.
Jeannine M. Mendrola +3 more
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Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. [PDF]
PLoS ONE, 2012 First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microarray (PM) technologies.
Ronald J Hause +5 more
doaj +2 more sources
Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors. [PDF]
BMC Cancer, 2015 Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constitutively activated variants of IGF-IR and EGFR ...
Urtasun N +3 more
europepmc +2 more sources