Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors. [PDF]
BMC Cancer, 2015 Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constitutively activated variants of IGF-IR and EGFR ...
Urtasun N +3 more
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Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression. [PDF]
Oncotarget, 2016 ErbB3, a member of the ErbB family receptors, has a key role in the development and progression of several cancers, including non-small cell lung cancer (NSCLC), and in the establishment of resistance to therapies, leading to the development of anti ...
Ciardiello C +13 more
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ErbB receptors and their growth factor ligands in pediatric intestinal inflammation. [PDF]
Pediatr Res, 2014 The ErbB tyrosine kinases (epidermal growth factor receptor (EGFR), ErbB2/HER2, ErbB3, and ErbB4) are cell surface growth factor receptors widely expressed in many developing mammalian tissues, including in the intestinal tract.
Frey MR, Brent Polk D.
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Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells. [PDF]
Sci Rep, 2015 The analysis of CAGE (Cap Analysis of Gene Expression) time-course has been proposed by the FANTOM5 Consortium to extend the understanding of the sequence of events facilitating cell state transition at the level of promoter regulation.
Mina M +13 more
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ERBB Receptors and Cancer: The Complexity of Targeted Inhibitors
Nature Reviews Cancer, 2005 ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression.
N. Hynes, H. Lane
semanticscholar +5 more sources
Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists [PDF]
iScienceSummary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović +10 more
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Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. [PDF]
PLoS ONE, 2010 The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is
Victoria E Abraira +3 more
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The Single Transmembrane Domains of ErbB Receptors Self-associate in Cell Membranes [PDF]
Journal of Biological Chemistry, 2002 Members of the epidermal growth factor receptor, or ErbB, family of receptor tyrosine kinases have a single transmembrane (TM) α-helix that is usually assumed to play a passive role in ligand-induced dimerization and activation of the receptor.
Jeannine M. Mendrola +3 more
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Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
PLoS ONE, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Inka Regine Weingaertner +2 more
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ERBB receptors in cancer: signaling from the inside. [PDF]
Breast Cancer Res, 2011 ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family.
Arteaga CL.
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