L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]
PLoS ONE, 2012 During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Emanuelle Donier +6 more
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Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. [PDF]
PLoS ONE, 2010 The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is
Victoria E Abraira +3 more
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Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
PLoS ONE, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Inka Regine Weingaertner +2 more
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The Role of ErbB Receptors in Infection. [PDF]
Trends Microbiol, 2017 Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Ho J, Moyes DL, Tavassoli M, Naglik JR.
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Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells. [PDF]
Sci Rep, 2017 Momeny M +21 more
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ErbB-receptors in antiestrogen resistance [PDF]
Breast Cancer Research, 2000 Valerie Speirs
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Identification of nucleolin as new ErbB receptors- interacting protein. [PDF]
PLoS ONE, 2008 BACKGROUND: The ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas.
Ayelet Di Segni +2 more
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The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
Epigenomes, 2023 Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC ...
Georgios Androutsopoulos +6 more
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Coupled stochastic spatial and non-spatial simulations of ErbB1 signaling pathways demonstrate the importance of spatial organization in signal transduction. [PDF]
PLoS ONE, 2009 BACKGROUND: The ErbB family of receptors activates intracellular signaling pathways that control cellular proliferation, growth, differentiation and apoptosis.
Michelle N Costa +4 more
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Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. [PDF]
PLoS ONE, 2012 First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microarray (PM) technologies.
Ronald J Hause +5 more
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