Results 11 to 20 of about 38,315 (266)

The Role of ErbB Receptors in Infection. [PDF]

Trends Microbiol, 2017
Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Ho J, Moyes DL, Tavassoli M, Naglik JR.
europepmc   +8 more sources

Targeting erbB receptors. [PDF]

Semin Cell Dev Biol, 2010
Our work is concerned with the origins and therapy of human cancers. Members of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, also known as erbB or HER receptors, are over expressed and/or activated in many types of human tumors and represent important therapeutic targets in cancer therapy.
Cai Z, Zhang H, Liu J, Berezov A, Murali R, Wang Q, Greene MI.   +6 more
europepmc   +5 more sources

A Structural Insight Into Two Important ErbB Receptors (EGFR and HER2) and Their Relevance to Non-Small Cell Lung Cancer. [PDF]

Arch Pharm (Weinheim)
This review evaluates the structures of epidermal growth factor receptor (EGFR) family members and investigates their relation to non‐small cell lung cancer (NSCLC). The development of fourth‐generation inhibitors like EAI045 and further innovative drugs to overcome this resistance problem is a must to cure EGFR‐related NSCLC.
Topalan E, Büyükgüngör A, Çiğdem M, Güra S, Sever B, Otsuka M, Fujita M, Demirci H, Ciftci H.   +8 more
europepmc   +2 more sources

Translocation of ErbB receptors into the nucleus [PDF]

Revista de Oncología, 2003
The work in the authors laboratory was financed by grants (to AV) from the Comisión Interministerial de Ciencia y Tecnología (SAF2002-03258), the Consejería de Educación de la Comunidad de Madrid (08.1/0027/2001-1), and the Agencia Española de Cooperación Internacional (2002CN0013).
Villalobo, Antonio, García-Andrés, Clara, Molina-Martínez, Patricia   +2 more
openaire   +2 more sources

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

Cancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu, Zicheng Yu, Yueping Liu, Lei Guo, Lianghong Teng, Lingchuan Guo, Li Liang, Jing Wang, Jie Gao, Ruiyu Li, Ling Yang, Xiu Nie, Dan Su, Zhiyong Liang   +13 more
wiley   +1 more source

Coupled stochastic spatial and non-spatial simulations of ErbB1 signaling pathways demonstrate the importance of spatial organization in signal transduction. [PDF]

PLoS ONE, 2009
BACKGROUND: The ErbB family of receptors activates intracellular signaling pathways that control cellular proliferation, growth, differentiation and apoptosis.
Michelle N Costa, Krishnan Radhakrishnan, Bridget S Wilson, Dionisios G Vlachos, Jeremy S Edwards   +4 more
doaj   +1 more source

Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin‐expressing interneurons, and inhibitory function in the auditory cortex

Glia, Volume 71, Issue 2, Page 187-204, February 2023., 2023
Main Point Loss of oligodendrocyte ErbB receptor signaling leads to A1 hypomyelination, reduced PV expression and density of PV+ neurons and synapses, hypoconnectivity of inhibitory circuits and shift of the E/I balance towards excitation. Abstract For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination
Beatriz C. Borges, Xiangying Meng, Patrick Long, Patrick O. Kanold, Gabriel Corfas   +4 more
wiley   +1 more source

Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. [PDF]

PLoS ONE, 2012
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microarray (PM) technologies.
Ronald J Hause, Kin K Leung, John L Barkinge, Mark F Ciaccio, Chih-Pin Chuu, Richard B Jones   +5 more
doaj   +1 more source

Betacellulin-Induced α-Cell Proliferation Is Mediated by ErbB3 and ErbB4, and May Contribute to β-Cell Regeneration

Frontiers in Cell and Developmental Biology, 2021
Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells.
Young-Sun Lee, Young-Sun Lee, Young-Sun Lee, Gyun Jee Song, Gyun Jee Song, Hee-Sook Jun, Hee-Sook Jun, Hee-Sook Jun   +7 more
doaj   +1 more source

Expression and function of ErbB receptors and ligands in the pituitary. [PDF]

Endocr Relat Cancer, 2011
The role of ErbB family in discreet pituitary functions is reviewed. Several ErbB receptor ligands, EGF, TGFα, and heregulin are differentially expressed in normal gonadotroph and lacto-somatotroph lineages, and other elements of the anterior pituitary. ErbB receptors, i.e.
Cooper O, Vlotides G, Fukuoka H, Greene MI, Melmed S.   +4 more
europepmc   +4 more sources