Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer [PDF]
Biomedicines, 2023 Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1) and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4) play an essential role in enhancing the proliferation, the migratory ...
Antonio Villalobo
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Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma [PDF]
Frontiers in Medicine, 2023 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type, has often an aggressive course and is poorly responsive to current therapeutic approaches, so that 5-year survival rates for patients diagnosed with advanced disease is ...
Camilla Palumbo +13 more
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Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo [PDF]
Journal of Translational Medicine, 2022 Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM.
Roberto Bei +17 more
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Targeting erbB receptors. [PDF]
Semin Cell Dev Biol, 2010 Our work is concerned with the origins and therapy of human cancers. Members of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, also known as erbB or HER receptors, are over expressed and/or activated in many types of human tumors and represent important therapeutic targets in cancer therapy.
Cai Z +6 more
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Role of ErbB receptors in cancer cell migration and invasion [PDF]
Frontiers in Pharmacology, 2015 Growth factors mediate their diverse biologic responses (regulation of cellular proliferation, differentiation, migration and survival) by binding to and activating cell-surface receptors with intrinsic protein kinase activity named Receptor Tyrosine ...
Aline eAppert-Collin +4 more
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The Role of ErbB Receptors in Infection. [PDF]
Trends Microbiol, 2017 Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Ho J, Moyes DL, Tavassoli M, Naglik JR.
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Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists [PDF]
iScienceSummary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović +10 more
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Regulation of sebaceous gland homeostasis and sebum secretion by the ERBB receptor family [PDF]
iScienceSummary: ERBB receptors are underappreciated regulators of cellular processes in the sebaceous gland (SG). They control sebocyte proliferation, differentiation, and lipid production - mechanisms that are essential for SG homeostasis, sebum secretion, and
Theresa Hommel +2 more
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Progress in the Research and Targeted Therapy of ErbB/HER Receptors in Urothelial Bladder Cancer
Frontiers in Molecular Biosciences, 2021 Bladder cancer is a lethal malignancy and a majority of bladder cancer arise from urothelial cells. Infiltration and metastasis are barriers for the radical cystectomy to achieve favored outcome and are the main cause of death.
Dong Chen +3 more
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The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
Epigenomes, 2023 Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC ...
Georgios Androutsopoulos +6 more
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