The Role of ErbB Receptors in Infection. [PDF]
Trends Microbiol, 2017 Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Ho J, Moyes DL, Tavassoli M, Naglik JR.
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Expression and function of ErbB receptors and ligands in the pituitary. [PDF]
Endocr Relat Cancer, 2011 The role of ErbB family in discreet pituitary functions is reviewed. Several ErbB receptor ligands, EGF, TGFα, and heregulin are differentially expressed in normal gonadotroph and lacto-somatotroph lineages, and other elements of the anterior pituitary ...
Cooper O +4 more
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Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells. [PDF]
Sci Rep, 2015 The analysis of CAGE (Cap Analysis of Gene Expression) time-course has been proposed by the FANTOM5 Consortium to extend the understanding of the sequence of events facilitating cell state transition at the level of promoter regulation.
Mina M +13 more
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The Single Transmembrane Domains of ErbB Receptors Self-associate in Cell Membranes [PDF]
Journal of Biological Chemistry, 2002 Members of the epidermal growth factor receptor, or ErbB, family of receptor tyrosine kinases have a single transmembrane (TM) α-helix that is usually assumed to play a passive role in ligand-induced dimerization and activation of the receptor.
Jeannine M. Mendrola +3 more
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Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
PLoS ONE, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Inka Regine Weingaertner +2 more
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Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists [PDF]
iScienceSummary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović +10 more
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Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. [PDF]
PLoS ONE, 2010 The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is
Victoria E Abraira +3 more
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Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. [PDF]
Breast Cancer Res, 2013 IntroductionTargeting receptor tyrosine kinases (RTKs) with kinase inhibitors is a clinically validated anti-cancer approach. However, blocking one signaling pathway is often not sufficient to cause tumor regression and the effectiveness of individual ...
Issa A +6 more
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Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. [PDF]
Endocrine-Related Cancer, 2003 The ErbB receptors and their cognate ligands that belong to the epidermal growth factor (EGF) family of peptides are involved in the pathogenesis of different types of carcinomas. In fact, the ErbB receptors and the EGF-like growth factors are frequently
Nicola Normanno +4 more
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ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. [PDF]
Cancer Cell, 2014 Arteaga CL, Engelman JA.
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