Results 31 to 40 of about 60,784 (262)

Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis

BMC Evolutionary Biology, 2006
Background In the time since we presented the first molecular evolutionary study of the ErbB family of receptors and the EGF family of ligands, there has been a dramatic increase in genomic sequences available. We have utilized this greatly expanded data
Staros James V, Stein Richard A
doaj   +1 more source

Translocation of ErbB receptors into the nucleus [PDF]

Revista de Oncología, 2003
The ErbB receptors are tyrosine kinases that bind a wide variety of ligands. They are implicated in cell proliferation, generation of anti-apoptotic signals, differentiation, and cell migration. The over-expression of different ErbB receptors and/or the expression of aberrant mutant forms are responsible for the development of many human cancers.
Villalobo, Antonio, Garcia-Andres, Clara, Molina Ortiz, Patricia   +2 more
openaire   +3 more sources

A molecular biology and phase II trial of lapatinib in children with refractory CNS malignancies: a pediatric brain tumor consortium study. [PDF]

, 2013
High expression of ERBB2 has been reported in medulloblastoma and ependymoma; EGFR is amplified and over-expressed in brainstem glioma suggesting these proteins as potential therapeutic targets. We conducted a molecular biology (MB) and phase II study to
Blaney, Susan M., Boyett, James M., Fouladi, Maryam, Gajjar, Amar, Geyer, J. Rusell, Gilbertson, Richard J., Goldman, Stewart, Kun, Larry E., Onar Thomas, Arzu, Packer, Roger J., Schaiquevich, Paula Susana, Stewart, Clinton F.   +11 more
core   +1 more source

Targeting the Calmodulin-Regulated ErbB/Grb7 Signaling Axis in Cancer Therapy

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Signal transduction pathways essential for the survival and viability of the cell and that frequently present aberrant expression or function in tumors are attractive targets for pharmacological intervention in human cancers. In this short review we will
Antonio Villalobo, Irene García-Palmero, Silviya R. Stateva, Karim Jellali   +3 more
doaj   +1 more source

Clinical relevance of soluble c-erbB-2 for patients with metastatic breast cancer predicting the response to second-line hormone or chemotherapy [PDF]

, 2002
Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent ...
Classen, S., Eiermann, W., Kopp, R., Possinger, K., Weidenhagen, R., Wilmanns, W.   +5 more
core   +1 more source

Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas.

PLoS ONE, 2008
BackgroundTamoxifen is still the most widely used drug in hormone therapy for the treatment of breast cancer. Its benefits in adjuvant treatment are well documented in controlled and randomized clinical studies, which have demonstrated an increase in ...
Valentina Folgiero, Paolo Avetrani, Giulia Bon, Selene E Di Carlo, Alessandra Fabi, Cecilia Nisticò, Patrizia Vici, Elisa Melucci, Simonetta Buglioni, Letizia Perracchio, Isabella Sperduti, Laura Rosanò, Ada Sacchi, Marcella Mottolese, Rita Falcioni   +14 more
doaj   +1 more source

Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer [PDF]

, 1999
Background: Tripe palms is a descriptive term for a cutaneous paraneoplastic keratoderma. Tripe palms are frequently associated with gastric and pulmonary carcinoma. The pathogenetic mechanism remains unknown.
Bezold, G., Dieterle, C., Greulich, K. M., Krähn, Gertraud, Peter, R. U., Wolff, H.   +5 more
core   +1 more source

The Dumb ErbB Receptor Helps Healing [PDF]

Journal of Investigative Dermatology, 2007
ErbB3 receptor is a member of the epidermal growth factor (EGF) receptor (ErbB1) family. Okwueze et al. have transfected this receptor in a pig model of wounds and demonstrate that it accelerates the resurfacing of the wounds when combined with epiregulin or heparin-binding EGF. Currently, only hypotheses can be proposed to explain the observations.
openaire   +3 more sources

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]

, 2016
Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R., Benvenuto, M, Bonanno, E, Cucchi, Danilo, DE SMAELE, Enrico, DI STEFANO, Enrica, Fantini, M, Frajese, Gv, Gulino, Alberto, Masuelli, Laura, Mattera, Rosanna, Modesti, A, Orlandi, A, Screpanti, Isabella   +13 more
core   +1 more source

Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia

Scientific Reports, 2017
Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri, Csilla Szabó, Oguz Kelemen   +2 more
doaj   +1 more source