Results 81 to 90 of about 2,350,327 (205)

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells

Journal of Cell Science, 2008
The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, also known as ErbB or HER, plays crucial roles in the development of multicellular organisms.
R. Tao, I. Maruyama
semanticscholar   +1 more source

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Correlation of c-erbB-2, EGF and EGFR expression with postoperative survival of patients with advanced carcinoma of the stomach.

Folia Histochemica et Cytobiologica, 2010
The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz, Jolanta Czyzewska, Andrzej Kemona   +2 more
doaj   +1 more source

Altered peripheral CRY1 gene expression may contribute to both organic and functional gastrointestinal disease

Experimental Physiology, EarlyView.
ABSTRACT Gastrointestinal conditions such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are characterized by alterations in physiological and immune functions. Given the circadian clock influences gastrointestinal physiology and immunity, we hypothesized that the peripheral circadian clock is altered in these patients and ...
Sophie Fowler, Gemma M. Paech, Emily C. Hoedt, Jennifer C. Pryor, Cheenie Nieva, Jessica K. Bruce, Prema M. Nair, Guy D. Eslick, Simonne Sherwin, Peter Pockney, Nicholas J. Talley, Grace L. Burns, Simon Keely   +12 more
wiley   +1 more source

Arrhythmic expression signatures of circadian clock‐associated transcription factors and chronic circadian disruption contribute to advanced prostate cancer growth

International Journal of Cancer, Volume 158, Issue 3, Page 775-789, 1 February 2026.
What's new? Circadian rhythm disruption potentially fuels prostate cancer progression. The mechanisms and signaling molecules contributing to hormonal tumorigenesis, however, remain largely undefined. In this study, circadian expression patterns of core‐circadian controlled genes (CCCGs) and nuclear receptors (NRs) were investigated in advanced ...
Ria Chopra, Haolong Li, Wenjuan Xie, Daniel Hau Tak Lam, Franky Leung Chan   +4 more
wiley   +1 more source

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Longevity and muscle strength are heritable traits, and age‐related muscle weakness is a major contributor to disability in older adults. However, the susceptibility genes and shared genetic mechanisms underlying lifespan and sarcopenia remain unclear.
Yilong Lin, Yun Zhang, Shengjie Lin, Songsong Wang, Zhiqiang Que, Yue Zhang, Jing She, Ruidan Zhao, Jiawei Chen, Anqi Qiu, Shinan Wu, Ruiqin Yang, Liyi Zhang, Qingmo Yang   +13 more
wiley   +1 more source

ERBB Receptors and Cancer: The Complexity of Targeted Inhibitors

Nature Reviews. Cancer, 2005
N. Hynes, H. Lane
semanticscholar   +2 more sources

Expression of c-erbB-2, p53 and c-myc proteins in male breast carcinoma: Comparison with traditional prognostic factors and survival

Brazilian Journal of Medical and Biological Research, 2001
There are few data evaluating biological markers for men with breast cancer. The purpose of the present study was to analyze the expression of the oncogenes c-erbB-2 and c-myc and of the suppressor gene p53 by immunohistochemical techniques in archival ...
M. Mourão Netto, A.F. Logullo, S. Nonogaki, R.R. Brentani, M.M. Brentani   +4 more
doaj   +1 more source

Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity [PDF]

, 2004
Bose Kochupurakkal, Daniel Harari, Ayelet Di‐Segni, Galia Maik-Rachline, Ljuba Lyass, Gal Gur, Gabriele Kerber, Ami Citri, Sara Lavi, Raya Eilam, Vered Chalifa‐Caspi, Zelig Eshhar, Eli Pikarsky, Ronit Pinkas‐Kramarski, Sarah Bacus, Yosef Yarden   +15 more
openalex   +1 more source