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A Semi-Mechanistic Mathematical Model of Immune Tolerance Induction to Support Preclinical Studies of Human Monoclonal Antibodies in Rats. [PDF]
PharmaceuticsGupta P, Ryman JT, Jawa V, Meibohm B.
europepmc +1 more source
ARISE: A Phase 3 randomized trial of erenumab for episodic migraine
Cephalalgia, 2018 Background: Calcitonin gene-related peptide plays an important role in migraine pathophysiology. Erenumab, a human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor, is being evaluated for migraine prevention.
Michel Lanteri-Minet +2 more
exaly +2 more sources
Pharmacology of erenumab in human isolated coronary and meningeal arteries: Additional effect of gepants on top of a maximum effect of erenumab [PDF]
British Journal of PharmacologyBackground and Purpose: Multiple drugs targeting the calcitonin gene-related peptide (CGRP) receptor have been developed for migraine treatment. Here, the effect of the monoclonal antibody erenumab on CGRP-induced vasorelaxation was investigated in human
Alexander Danser, Tessa de Vries
exaly +2 more sources
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Erenumab for episodic migraine
Pain Management, 2022In this review, the authors provide an overview of erenumab, a monoclonal antibody used for the preventative treatment of episodic migraine by targeting the CGRP pathway. Randomized controlled trials have shown that erenumab is associated with a statistically significant decrease in monthly migraine days in patients with episodic migraine at monthly ...
Abhigyan Datta +5 more
openaire +2 more sources
pharma-kritik, 2018
Ein neues Medikament, das zur Prävention bei Migräne eingesetzt werden kann. Erenumab, das einmal monatlich subkutan injiziert wird, hat sich in mehreren Studien als wirksamer als Placebo gezeigt.
openaire +1 more source
Ein neues Medikament, das zur Prävention bei Migräne eingesetzt werden kann. Erenumab, das einmal monatlich subkutan injiziert wird, hat sich in mehreren Studien als wirksamer als Placebo gezeigt.
openaire +1 more source
Erenumab in the Treatment of Migraine
Pain Management, 2018Migraine is a highly prevalent neurological pain syndrome, and its management is limited due to side effects posed by current preventive therapies. Calcitonin gene-related peptide (CGRP) plays a crucial role in the pathogenesis of migraine. In recent years, research has been dedicated to the development of monoclonal antibodies against CGRP and CGRP ...
Sameer, Jain +3 more
openaire +2 more sources