Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae [PDF]
, 2017 Azole-resistant strains of Aspergillus fumigatus have been detected and the underlying molecular mechanisms of resistance characterized. Point mutations in the cyp51A gene have been proved to be related to azole resistance in A.
Alcazar-Fuoli, L. +3 more
core
International journal of molecular epidemiology and genetics, 2012 Fluconazole resistance is an important type of resistance in Candida because in most countries, fluconazole is the drug of choice for vulvovaginal candidiasis. Candida species resist fluconazole by various mechanisms but there is paucity of data on these in our environment.
Victoria K Pam +7 more
openalex +4 more sources
The Inner Nuclear Membrane Has a Unique Lipid Signature
BioEssays, Volume 47, Issue 10, October 2025.The inner nuclear membrane (INM) has a distinct lipid profile, most notably characterized by high enrichment of phosphatidylserine (PS). In this review, Yang Niu and Tamas Balla summarize recent advances in elucidating the INM's lipid composition and related metabolic pathways, while elaborating further on their potential functional roles.
Yang Niu, Tamas Balla
wiley +1 more source
Emerging Threats in Antifungal-Resistant Fungal Pathogens. [PDF]
, 2016 The use of antifungal drugs in the therapy of fungal diseases can lead to the development of antifungal resistance. Resistance has been described for virtually all antifungal agents in diverse pathogens, including Candida and Aspergillus species.
Sanglard, D.
core +2 more sources
Structural basis for heterogeneous phenotype of ERG11 dependent Azole resistance in C.albicans clinical isolates [PDF]
SpringerPlus, 2014 Correlating antifungal Azole drug resistance and mis-sense mutations of ERG11 has been paradoxical in pathogenic yeast Candida albicans. Amino acid substitutions (single or multiple) are frequent on ERG11, a membrane bound enzyme of Ergosterol biosynthesis pathway. Presence or absence of mutations can not sufficiently predict susceptibility. To analyze
Debnath, Surajit, Addya, Soma
openaire +2 more sources
The role of Isocitrate Lyase (ICL1) in the metabolic adaptation of Candida albicans biofilms [PDF]
, 2016 Background A major characteristic of Candida biofilm cells that differentiates them from free-floating cells is their high tolerance to antifungal drugs.
Brown A +8 more
core +2 more sources
Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility [PDF]
, 2021 Benjamin Williamson +12 more
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Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks [PDF]
, 2018 A significant challenge in our understanding of biological systems is the high number of genes with unknown function in many genomes. The fungal genus Aspergillus contains important pathogens of humans, model organisms, and microbial cell factories ...
Baumann, Birgit +10 more
core +1 more source
Microbial Biotechnology, Volume 18, Issue 10, October 2025.Chromosome III aneuploidy elevates TUP1 dosage and boosts ethanol tolerance by modulating stress‐response pathways, validated through RNA‐seq and targeted TUP1 copy number reduction. ABSTRACT Ethanol stress poses a considerable challenge for Saccharomyces cerevisiae during fermentation.
Sonia Albillos‐Arenal +4 more
wiley +1 more source
Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea [PDF]
Emerging Infectious Diseases, 2018 We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hospitals for several years, as revealed by microsatellite
Yong Jun Choi +11 more
openaire +3 more sources