Early Detection of Fluconazole Resistance Targeting Y132F Mutation in ERG11 Gene Among Candida Tropicalis Clinical Isolates using Polymerase Chain Reaction: A Cross-sectional Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Candida tropicalis is the most prevalent yeast associated with high mortality rates in candidaemia patients. The extensive use of fluconazole for prophylaxis has led to the emergence of resistance.
Kanagasabapathi Karthika +5 more
doaj +1 more source
Essential gene identification and drug target prioritization in Aspergillus fumigatus.
PLoS Pathogens, 2007 Aspergillus fumigatus is the most prevalent airborne filamentous fungal pathogen in humans, causing severe and often fatal invasive infections in immunocompromised patients.
Wenqi Hu +11 more
doaj +1 more source
Mechanism of Action of a Novel Antifungal Compound [PDF]
, 2012 Opportunistic fungal infections have become problematic in recent years. There has been an emergence of new fungal pathogens, development of antifungal resistance, and increasing prevalence.
Ward, Amber
core +1 more source
Molecular analysis of ERG11 gene in azole resistant Candida Species among immunocompromised patients
Abstract Background: Candida species are opportunistic pathogens that can cause life-threatening infections, especially in immunocompromised patients. Azole antifungals are widely used for treatment, but resistance is increasing and often due to mutations in the ...
Amal H. Salem +5 more
openaire +1 more source
O factor de trancrição NDT80 como regulator negativo da adesão e da formação de biofilme em Candida parapsilosis [PDF]
, 2014 Mestrado em Biologia Molecular e CelularC. parapsilosis infections incidence has been increasing for the past 20 years. Its caracteristics of adhering and forming biofilms are a critical factor for infection caused by this organism, affecting from ...
Gomes, Nuno Miguel Araújo da Cunha
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Fluconazole-resistant Candida parapsilosis strains with a Y132F substitution in the ERG11 gene causing invasive infections in a neonatal unit, South Africa. [PDF]
Mycoses, 2020 Magobo RE, Lockhart SR, Govender NP.
europepmc +1 more source
مجلة بغداد للعلومAs the population of immunocompromised patients grew, yeast infections became more common. There has been a significant rate of morbidity and mortality among patients with Candidiasis demonstrating increased resistance to antifungal medications.
Muhamed Abd ulrahman Majeed +2 more
doaj +1 more source
Universal PCR assays to detect Candida FKS and ERG11 mutations
International Journal of Infectious DiseasesIntroduction: The emergence of antifungal resistance in Candida species presents significant challenges in managing infections, particularly among immunocompromised patients.
Dr Yuk Yam Cheung +4 more
doaj +1 more source
Mecanismes d'acció dels antifúngics i resistència en llevats [PDF]
, 2005 Si bé s'ha avançat en la síntesi de nous antifúngics i se'n coneix el mode d'acció, els mecanismes moleculars de resistència encara són insuficientment coneguts, i afecten principalment els llevats i els azoles.
Alvarado Ramírez, Eidi +2 more
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mSphereIncidences of fluconazole (FLC) resistance among Candida glabrata clinical isolates are a growing issue in clinics. The pleiotropic drug response network in C.
Thomas P. Conway +4 more
doaj +1 more source