Results 121 to 130 of about 3,364 (161)

Engineering <i>Yarrowia lipolytica</i> for high-level ergosterol production. [PDF]

Synth Syst Biotechnol
Liu X, Chen Q, Zhao W, Li Q, Xiao L, He Q, Zeng W, Zhou J.   +7 more
europepmc   +1 more source

The azole-resistance phenotype of a <i>Nakaseomyces glabratus</i> clinical strain encoding a wild-type <i>PDR1</i> allele involves the efflux pumps Aus1 and Pdh1 and Cyb5, an alternative reductase required for ergosterol biosynthesis. [PDF]

Microbiol Spectr
Pinheiro MJ, Parker JE, Ferreira MT, Fernandes F, Mira NP.   +4 more
europepmc   +1 more source

Chitosan nanoparticles loaded with ribavirin, carboplatin, and thyme oil downregulate SNQ2, ERG11, CDR1, and MDR1 in Candida strains. [PDF]

Sci Rep
Aghaei S, Yadegari MH, Rajabibazl M, Ansari S, Amani J.   +4 more
europepmc   +1 more source

A quiet but growing threat: Global perspectives on antifungal resistance and future therapeutic approaches. [PDF]

Indian J Pharmacol
Gurajala S, Challapilla M.
europepmc   +1 more source

Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles' antifungal activities. [PDF]

Nat Commun
Li W, Whiteway M, Hang S, Yu J, Lu H, Jiang Y.   +5 more
europepmc   +1 more source

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Detection of ERG11 gene in fluconazole resistant urinary candida isolates

Egyptian journal of Immunology, 2022
Candida species resistant to fluconazole and voriconazole were screened for the presence of ERG11gene by polymerase chain reaction (PCR). Also, the association of this gene with the demonstration of Candida virulence factors; biofilm formation, phospholipase and proteinases activities were studied.
Manal, El Said, Hala, Badawi, Doaa, Gamal, Dalia, Salem, Heba, Dahroug, Amira, El-Far   +5 more
openaire   +2 more sources

The new mutation L321F in Candida albicans ERG11 gene may be associated with fluconazole resistance

Revista Iberoamericana De Micologia, 2013
For many years fluconazole has been commonly used to treat Candida infections. However, the indiscriminate use of this antimycotic therapy has favored the emergence of resistant isolates. Mutations in the ERG11 gene have been described as one of the primary mechanisms of resistance in Candida species.In this study we investigated missense mutations in ...
Melhem Msc, Maria Walderez Szeszs
exaly   +3 more sources

The A395T Mutation in ERG11 Gene Confers Fluconazole Resistance in Candida tropicalis Causing Candidemia

Mycopathologia, 2014
The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the isolate was determined by using CLSI M27-A3 and E-test methods. The sequence of ERG11 gene was then
Zhe Wan, Jingwen Tan, Ruoyu Li
exaly   +3 more sources

Implication of efflux pumps and ERG11 genes in resistance of clinical Trichosporon asahii isolates to fluconazole

Journal of Medical Microbiology, 2021
Introduction. Trichosporon asahii has been recognized as an opportunistic agent having a limited sensitivity to antifungal treatment. Hypothesis/Gap Statement. Molecular mechanisms of azole resistance have been rarely reported for Trichosproron asahii.
S, Abbes, H, Sellami, S, Neji, H, Trabelsi, F, Makni, A, Ayadi   +5 more
openaire   +2 more sources