mSphereThe widespread use of azole antifungals in agriculture and clinical settings has led to serious drug resistance. Overexpression of the azole drug target 14α-demethylase ERG11 (CYP51) is the most common fungal resistance mechanism.
Pengju Yu +7 more
doaj +1 more source
Insights into the structure, function, and impact of Candida albicans UPC2 gene on azole resistance; a mini-review [PDF]
Current Medical MycologyBackground and Purpose: Candidiasis is a prevalent fungal infection caused by various species of Candida, especially, C. albicans. The emergence of resistance to azole medications, which are frequently prescribed for the treatment of Candida infections ...
Akbar Hoseinnejad +10 more
doaj +1 more source
Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity [PDF]
, 2018 Inactivation of sterol Δ5,6-desaturase (Erg3p) in the prevalent fungal pathogen Candida albicans is one of several mechanisms that can confer resistance to the azole antifungal drugs.
Alspaugh, J. Andrew +10 more
core +2 more sources
Genetic and Proteomic Approaches to Identify Cancer Drug Targets [PDF]
, 2011 While target-based small-molecule discovery has taken centre-stage in the pharmaceutical industry, there are many cancer-promoting proteins not easily addressed with a traditional target-based screening approach. In order to address this problem, as well
A Subramanian +46 more
core +1 more source
Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates [PDF]
, 2016 Cryptococcus spp. are responsible for around one million cases of meningitis every year. Fluconazole (FLU) is commonly used in the treatment of cryptococcosis, mainly in immunocompromised patients and the resistance is usually reported after long periods
Ana Cecilia Mesa-Arango +9 more
core +5 more sources
Comparative Analysis of Two Candida parapsilosis Isolates Originating from the Same Patient Harbouring the Y132F and R398I Mutations in the ERG11 Gene. [PDF]
Cells, 2023 Štefánek M +4 more
europepmc +1 more source
Tipping the balance both ways: drug resistance and virulence in Candida glabrata [PDF]
, 2017 Among existing fungal pathogens, Candida glabrata is outstanding in its capacity to rapidly develop resistance to currently used antifungal agents. Resistance to the class of azoles, which are still widely used agents, varies in proportion (from 5 to 20%)
Bolotin-Fukuhara, Monique +2 more
core
Doxorubicin induces drug efflux pumps in Candida albicans [PDF]
, 2017 Candida albicans is one of the most important opportunistic fungal pathogens. It can cause serious fungal diseases in immunocompromised patients, including those with cancer. Treatment failures due to the emergence of drug-resistant C.
Coste, Alix T. +8 more
core
The influence of genetic stability on Aspergillus fumigatus virulence and azole resistance [PDF]
, 2018 Genetic stability is extremely important for the survival of every living organism, and a very complex set of genes has evolved to cope with DNA repair upon DNA damage.
Carmo, Rafaela Andrade do +10 more
core +4 more sources
The CgHaa1-dependent pathway mediates Candida glabrata response and tolerance to acetic acid thereby enhancing colonization of vaginal epithelium [PDF]
, 2014 To successfully colonize the vaginal tract Candida glabrata has to cope with various stresses including the presence of acetic acid at a low pH that is produced by the bacteria that co-colonize this niche. The genes/pathways involved in C.
Azeredo, Joana +9 more
core