Results 1 to 10 of about 2,476 (230)
High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines. [PDF]
PLoS Genetics, 2016 Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells.
Ireos Filipuzzi +13 more
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Ergolines as selective 5-HT1 agonists
Journal of Medicinal Chemistry, 1988 The synthesis and serotonin receptor subtype affinity of a series of ergolines are described. High selectivity for the 5-HT1 subtype was found with a number of 8-substituted (3 beta, 5 beta)-9,10-didehydro-6-methylergolines. The more potent and selective of these compounds increased the concentration of serotonin and decreased the concentration of 5 ...
John S. Ward +6 more
semanticscholar +4 more sources
Biological studies of clavine alkaloids targeting CNS receptors [PDF]
Frontiers in Psychiatry, 2023 In contrast to well established psychedelics such as lysergic acid diethylamide (LSD) and psilocybin, ergot alkaloids of the clavine subclass have not been thoroughly investigated, in spite of their broad occurrence in nature and their well-established ...
Nikhil R. Tasker +2 more
doaj +2 more sources
Synthetic Strategies toward Lysergic Acid Diethylamide: Ergoline Synthesis via α-Arylation, Borrowing Hydrogen Alkylation, and C-H Insertion. [PDF]
J Org Chem, 2023 Lysergic acid diethylamide (LSD), a semisynthetic ergoline alkaloid analogue and hallucinogen, is a potent psychoplastogen with promising therapeutic potential.
Tuck JR, Dunlap LE, Olson DE.
europepmc +3 more sources
Psychedelics: A new era of treatment? [PDF]
European Psychiatry, 2021 Introduction Psychedelics - including LSD (lysergic acid diethylamide), psilocybin, DMT (N, N-dimethyltryptamine), ayahuasca and mescaline - have an ancient history across various civilizations.
S. Torres
doaj +2 more sources
Emerging Trends in Drugs, Addictions, and HealthIntroduction: Serotonergic psychedelics induce their characteristic subjective effects via activation of the serotonin 2A receptor (5-HT2AR). This structurally diverse class of drugs includes ergolines (e.g., LSD), phenethylamines (e.g., mescaline), and ...
E. Pottie +3 more
doaj +2 more sources
Pleuropulmonary changes induced by ergoline drugs [PDF]
European Respiratory Journal, 1996 Classic ergolines, such as bromocriptine, methysergide and ergotamine, can induce chronic pleuropneumonitis. We present the cases of eight patients who developed similar changes whilst on other ergolines. In this retrospective case study spanning 1985-1995, clinical data, radiological material, pulmonary function, bronchoalveolar lavage and ...
Pierre Pfitzenmeyer +7 more
openalex +4 more sources
Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore. [PDF]
ACS Pharmacol Transl Sci, 2021 Psychedelic drugs can exert potent anti-inflammatory effects. However, anti-inflammatory effects do not appear to correlate with behavioral activity, suggesting different underlying mechanisms.
Flanagan TW +5 more
europepmc +3 more sources
5-HT<sub>2A</sub> receptors: Pharmacology and functional selectivity. [PDF]
Pharmacol RevSerotonin 5-HT receptors were one of the first serotonin receptors to be pharmacologically characterized. In mammals, they are expressed throughout the body in nearly every cell and tissue type, with the highest density in cortical layer V of the brain ...
Cummins BR +3 more
europepmc +3 more sources
Ropinirole, a Non‐Ergoline Dopamine Agonist [PDF]
CNS Drug Reviews, 2005 ABSTRACTDopamine agonists have become indispensable in the treatment of Parkinson's disease. In every‐day practice, however, the decision to select the best compound for an individual patient is rendered difficult because of the large number of substances available on the market.
Wolfgang H. Jost, Dieter Angersbach
openalex +3 more sources