High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines. [PDF]
PLoS Genetics, 2016 Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells.
Ireos Filipuzzi +13 more
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Synthetic Strategies toward Lysergic Acid Diethylamide: Ergoline Synthesis via α-Arylation, Borrowing Hydrogen Alkylation, and C-H Insertion. [PDF]
J Org Chem, 2023 Lysergic acid diethylamide (LSD), a semisynthetic ergoline alkaloid analogue and hallucinogen, is a potent psychoplastogen with promising therapeutic potential.
Tuck JR, Dunlap LE, Olson DE.
europepmc +5 more sources
Biological studies of clavine alkaloids targeting CNS receptors [PDF]
Frontiers in Psychiatry, 2023 In contrast to well established psychedelics such as lysergic acid diethylamide (LSD) and psilocybin, ergot alkaloids of the clavine subclass have not been thoroughly investigated, in spite of their broad occurrence in nature and their well-established ...
Nikhil R. Tasker +2 more
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Psychedelics: A new era of treatment? [PDF]
European Psychiatry, 2021 Introduction Psychedelics - including LSD (lysergic acid diethylamide), psilocybin, DMT (N, N-dimethyltryptamine), ayahuasca and mescaline - have an ancient history across various civilizations.
S. Torres
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Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore. [PDF]
ACS Pharmacol Transl Sci, 2021 Psychedelic drugs can exert potent anti-inflammatory effects. However, anti-inflammatory effects do not appear to correlate with behavioral activity, suggesting different underlying mechanisms.
Flanagan TW +5 more
europepmc +3 more sources
5-HT<sub>2A</sub> receptors: Pharmacology and functional selectivity. [PDF]
Pharmacol RevSerotonin 5-HT receptors were one of the first serotonin receptors to be pharmacologically characterized. In mammals, they are expressed throughout the body in nearly every cell and tissue type, with the highest density in cortical layer V of the brain ...
Cummins BR +3 more
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Monitoring Surface Defects Deformations and Displacements in Hot Steel Using Magnetic Induction Tomography [PDF]
Sensors, 2019 Magnetic Induction Tomography (MIT) is a non-invasive imaging technique that has been widely applied for imaging materials with high electrical conductivity contrasts.
Fang Li +3 more
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Machine learning vs. field 3D-QSAR models for serotonin 2A receptor psychoactive substances identification. [PDF]
RSC Adv, 2021 Serotonergic psychedelics, substances exerting their effects primarily through the serotonin 2A receptor (5HT2AR), continue to comprise a substantial portion of reported new psychoactive substances (NPS).
Floresta G, Abbate V.
europepmc +3 more sources
Self-Reported Efficacy of Treatments in Cluster Headache: a Systematic Review of Survey Studies. [PDF]
Curr Pain Headache Rep, 2022 Purpose of Review The use and efficacy of various substances in the treatment of CH have been studied in several retrospective surveys. The aim of the study is to systematically review published survey studies to evaluate the reported efficacies of both ...
Rusanen SS +4 more
europepmc +3 more sources
Galactorrhea: how to address this unusual complication after augmentation mammoplasty [PDF]
Revista Brasileira de Cirurgia Plástica, 2016 INTRODUCTION: Galactorrhea and galactocele formation after breast augmentation are complications reported in the literature, but the cause remains unknown.
Adriana Sayuri Kurogi Ascenço +4 more
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