Results 121 to 130 of about 2,032 (166)
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Amesergide and structurally related nor-D-ergolines: 5HT2 receptor interactions in the rat.
Journal of Medicinal Chemistry, 1993A series of tricyclic (nor-D) partial ergolines were synthesized via a highly convergent enantiospecific strategy, ultimately arising from a racemic tricyclic ketone.
M. Martinelli +3 more
semanticscholar +1 more source
Sequential Aminodiene Diels−Alder Approach to the Ergoline Skeleton
The Journal of Organic Chemistry, 2005Through a novel sequence of aminodiene Diels-Alder reactions, several substituted amidofurans were readily converted to tricyclic ketones in good yield. The formation of the tricyclic ketone system is the result of a ring opening and dehydration of a transient oxabicyclic adduct formed by an intramolecular Diels-Alder cycloaddition of an amidofuran ...
Albert Padwa +2 more
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Luminescence characteristics of lysergic acid diethylamide and related ergolines
, 1973The fluorescence and phosphorescence characteristics of lysergic acid diethylamide and a number of related ergolines have been examined. Fluorescence decay times have been determined using a time-correlated single photon counting technique.
A. Bowd, J. Hudson, J. Turnbull
semanticscholar +1 more source
, 1986
Novel (5R,8S,10R)-6-(allyloxy)- and (5R,8S,10R)-6-(propyloxy)ergolines have been synthesized by use of a Meisenheimer [2,3]-sigmatropic rearrangement of a (5R,8S,10R)-6-allyl-ergoline N6-oxide as key step.
R. Nordmann, P. Gull
semanticscholar +1 more source
Novel (5R,8S,10R)-6-(allyloxy)- and (5R,8S,10R)-6-(propyloxy)ergolines have been synthesized by use of a Meisenheimer [2,3]-sigmatropic rearrangement of a (5R,8S,10R)-6-allyl-ergoline N6-oxide as key step.
R. Nordmann, P. Gull
semanticscholar +1 more source
Dopaminergic activity of some simplified ergoline derivatives
Drug Development Research, 1981AbstractThe dopamine (DA) agonist activity of new simplified ergoline derivatives (RU 27849, RU 28251, and RU 28306) was studied in comparison with bromocriptine. In contrast to bromocriptine, the three compounds were weak displacers of 3H‐dihydroergocriptine or 3H‐spiroperidol binding from bovine anterior pituitary or rat striatal membrane sites and ...
Catherine Euvrard +5 more
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, 1994
Amesergide and LY215840 are potent and long‐lasting 5‐HT2 receptor antagonists after oral administration to animals. In animals, these ergolines are metabolized to their desisopropyl ergoline congeners which have lower affinity (40–60 nM) at 5‐HT2 ...
Marlene L. Cohen, W. Bloomquist
semanticscholar +1 more source
Amesergide and LY215840 are potent and long‐lasting 5‐HT2 receptor antagonists after oral administration to animals. In animals, these ergolines are metabolized to their desisopropyl ergoline congeners which have lower affinity (40–60 nM) at 5‐HT2 ...
Marlene L. Cohen, W. Bloomquist
semanticscholar +1 more source
In vivo and in vitro dopaminergic effects of three ergoline fragments
Naunyn-Schmiedeberg's Archives of Pharmacology, 1984The pharmacological effects of three ergoline fragments (BD-179, BD-271 and BD-214) were studied in vivo using the cat cardioaccelerator nerve preparation and in vitro using field stimulated isolated cat right atria. BD-179 and BD-271 produced dose dependent inhibition of tachycardia due to electrical stimulation of the right postganglionic ...
John P. Long +2 more
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Initial treatment of parkinsonism with 8‐alpha‐amino‐ergoline
Neurology, 1985We treated 12 patients with Parkinson's disease with an 8-alpha-amino-ergoline derivative, CU 32-085. The daily dosage was increased slowly to 7 mg over 9 weeks, held constant for 8 weeks, then replaced by placebo for 4 weeks. We found statistically significant benefit over placebo or pretreatment disability.
Juha Huttunen +2 more
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Radioimmunoassay for the Synthetic Ergoline Derivative Cabergoline in Biological Fluids
Journal of Immunoassay, 1992An antiserum against cabergoline, a powerful dopamine-agonist under clinical trials for the treatment of Parkinson's disease and hyperprolactinemia, has been raised in rabbits by immunization with an immunogen produced by conjugation of cabergoline to bovine serum albumin. The antiserum was able to bind a derivative of cabergoline labelled with tritium
M. Strolin Benedetti +4 more
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Ergoline congeners as potential inhibitors of prolactin release 2
Journal of Medicinal Chemistry, 1976AbstractIndol (Ia) wird mit Oxalylchlorid zu (Ib) substituiert und nach Überführung in das Amid (II) zum Amin (IIIa) reduziert.
Charles F. Barfknecht +2 more
openaire +4 more sources