Results 31 to 40 of about 1,329 (197)
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
The History and Pharmacology of Dopamine Agonists [PDF]
, 2017 The recognition of the dopaminergic properties of some ergot derivatives has initiated new therapeutical approaches in endocrinology as well as in neurology.
Lataste, X.
core
Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists
British Journal of Pharmacology, EarlyView.Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley +1 more source
Psychedelics: preclinical insights provide directions for future research [PDF]
, 2023 Recently, psychedelics have emerged as promising therapeutics for numerous neuropsychiatric disorders. While their potential in the clinic has yet to be fully elucidated, understanding their molecular and biological mechanisms is imperative as these ...
Gumpper R.H, Roth B.L
core +2 more sources
Psychedelics, entactogens and psychoplastogens for depression and related disorders
British Journal of Pharmacology, EarlyView.Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley +1 more source
Species differences in 5-HT2A receptors: cloned pig and rhesus monkey 5-HT2A receptors reveal conserved transmembrane homology to the human rather than rat sequence [PDF]
, 1995 Pig and rhesus monkey 5-HT2A receptor cDNA clones were isolated. The pig and rhesus monkey clones encode proteins that share a 94% and 95% homology, respectively, with the rat 5-HT2A receptor, and a 97% and > 99% homology, respectively, with the human 5 ...
Baez, Melvyn +3 more
core +1 more source
Experimental Physiology, EarlyView.Abstract The aim of this retrospective analysis was to provide a more comprehensive understanding of the cardiorespiratory profile of world‐class ILCA‐7 sailors (n = 3, all males), through a longitudinal evaluation offering real‐world data on physiological profile and exercise intensity domains. The cardiopulmonary exercise testing (CPET) was performed
Damir Zubac +2 more
wiley +1 more source
Crystallographic and NMR Investigation of Ergometrine and Methylergometrine, Two Alkaloids from Claviceps purpurea [PDF]
, 2020 Ergometrine and methylergometrine are two alkaloids that are used as maleate salts for the prevention and control of postpartum hemorrhage. Although the two molecules have been known for a long time, few and discordant crystallographic and NMR ...
F. Meneghetti +5 more
core +1 more source
Experimental Physiology, EarlyView.Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger +10 more
wiley +1 more source
Repetition‐dependent acute cardiopulmonary responses during intensity‐matched squats in males
Experimental Physiology, EarlyView.Abstract The ‘strength–endurance continuum’ is a key concept in strength training (ST). Although cardiopulmonary responses have seldom been reported in conjunction with ST, this repeated‐measurement study examined acute blood pressure and haemodynamic responses continuously depending on the number of repetitions but without changing the intensity ...
Johannes Lässing +5 more
wiley +1 more source