Self-Reported Efficacy of Treatments in Cluster Headache : a Systematic Review of Survey Studies [PDF]
, 2022 Purpose of Review The use and efficacy of various substances in the treatment of CH have been studied in several retrospective surveys. The aim of the study is to systematically review published survey studies to evaluate the reported efficacies of both ...
Artto, Ville Aleksi +4 more
core +1 more source
Synthesis, Evaluation, and Characterization of an Ergotamine Imprinted Styrene-Based Polymer for Potential Use as an Ergot Alkaloid Selective Adsorbent [PDF]
, 2021 Alkaloid toxicities negatively impact livestock health and production. To assess alkaloid occurrences, adsorbent technologies may offer effective means to their extraction and isolation from a complex feed matrix.
Kudupoje, Manoj B. +3 more
core +2 more sources
Machine learning vs. field 3D-QSAR models for serotonin 2A receptor psychoactive substances identification [PDF]
, 2021 Serotonergic psychedelics, substances exerting their effects primarily through the serotonin 2A receptor (5HT2AR), continue to comprise a substantial portion of reported new psychoactive substances (NPS).
Abbate, Vincenzo, Floresta, Giuseppe
core +2 more sources
Voltage sensitivity of dopamine D2-like receptors [PDF]
, 2011 G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands.
Sahlholm, Kristoffer
core +1 more source
MoleculesA total of 250 known and novel compounds—ketamine and serotonergic psychedelics or their analogues—designed to target depression, addictions and/or other mental or neurological disorders and developed as “recreational” (illegal) drugs from three chemical
Anna W. Sobańska +2 more
doaj +1 more source
Synthetic studies on polycyclic indole alkaloids [PDF]
, 2006 The first part of this work details the formal total synthesis of HKI 0231B and the first total synthesis of both demethyl HKI 0231A and demethyl HKI 0231B. The formal synthesis used TBAF as a mild reagent to construct the indole.
Wu, Tao
core +3 more sources
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens [PDF]
, 2016 The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD ...
Hoener, Marius C. +3 more
core +1 more source
Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists
British Journal of Pharmacology, EarlyView.Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley +1 more source
Crystal Structure of an LSD-Bound Human Serotonin Receptor [PDF]
, 2017 SummaryThe prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the crystal structure of LSD in complex with the human serotonin receptor 5-HT2B.
Betz, Robin M. +12 more
core +2 more sources