Results 61 to 70 of about 2,476 (230)

Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation (TSPO availability) in monozygotic twin pairs discordant for BMI—Exercise training reverses increased brain activity

Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 7097-7109, December 2025.
Abstract Aims Obesity is associated with increased insulin‐stimulated brain glucose uptake (BGU) which is opposite to decreased GU observed in peripheral tissues. Increased BGU was shown to be reversed by weight loss and exercise training, but the mechanisms remain unknown.
Jaakko Hentilä, Jouni Tuisku, Ronja Ojala, Lihua Sun, Martin S. Lietzén, Heidi Virtanen, Riikka Lautamäki, Kalle Koskensalo, Lauri Nummenmaa, Eliisa Löyttyniemi, Semi Helin, Kirsi H. Pietiläinen, Jaakko Kaprio, Leo Lahti, Tarja Malm, Juha O. Rinne, Jarna C. Hannukainen   +16 more
wiley   +1 more source

Sex differences in the work of breathing during exercise are independent of forced vital capacity in healthy adults

Experimental Physiology, Volume 110, Issue 12, Page 2036-2048, December 1, 2025.
Abstract During exercise, females have a higher work of breathing (ẆB) than males for a given minute ventilation (V̇E$ \dot {V}_{\text {E}}$) ≥ 50–60 L min−1, presumably due to sex differences in airway size. However, on average, males have greater forced vital capacity (FVC) than females, and the confounding effect of FVC on sex differences in ẆB is ...
Gracie O. Grift, Jack R. Dunsford, Jasvir K. Dhaliwal, Paolo B. Dominelli, Yannick Molgat‐Seon   +4 more
wiley   +1 more source

Associations of Physical Activity and Dietary Fat Quality With Arterial Health in Adolescents

Pediatric Obesity, Volume 20, Issue 11, November 2025.
ABSTRACT Background While the clinical signs of cardiovascular diseases (CVDs) are not usually visible until adulthood, the CVD pathology begins already in childhood. Objectives To study the associations of physical activity (PA) and dietary fat quality with arterial health among adolescents.
Mika Jormanainen, Aino‐Maija Eloranta, Marja H. Leppänen, Tomi Laitinen, Mika Kähönen, Emilia Laitinen, Timo A. Lakka, Eero A. Haapala   +7 more
wiley   +1 more source

Setting sail for Paris 2024: Retrospective analysis of world‐class ILCA 7 Olympic sailors’ cardiorespiratory fitness (2015–2020)

Experimental Physiology, Volume 110, Issue 11, Page 1576-1583, November 1, 2025.
Abstract The aim of this retrospective analysis was to provide a more comprehensive understanding of the cardiorespiratory profile of world‐class ILCA‐7 sailors (n = 3, all males), through a longitudinal evaluation offering real‐world data on physiological profile and exercise intensity domains. The cardiopulmonary exercise testing (CPET) was performed
Damir Zubac, Zoran Valić, Vladimir Ivančev   +2 more
wiley   +1 more source

Pattern of extra‐diaphragmatic respiratory muscle activity during exercise in patients with unilateral diaphragm dysfunction

Physiological Reports, Volume 13, Issue 21, November 2025.
Abstract Whether extra‐diaphragmatic respiratory muscle output is altered in patients with unilateral diaphragm dysfunction (UDD) remains unclear. We compared respiratory pressures and muscle activity during symptom‐limited cardiopulmonary exercise testing (CPET) in 10 patients with UDD and 10 matched controls.
Antenor Rodrigues, Zafeiris Louvaris, Sauwaluk Dacha, Mayra Caleffi Pereira, Tin Gojevic, Michele R. Schaeffer, Luc Janssens, Wim Janssens, W. Darlene Reid, Ghislaine Gayan‐Ramirez, Dries Testelmans, Laurent Brochard, Rik Gosselink, Daniel Langer   +13 more
wiley   +1 more source

Structural Features for Functional Selectivity at Serotonin Receptors [PDF]

, 2013
Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or non-canonical signaling pathways via a phenomenon known as functional selectivity or biased signaling.
Cherezov, V., Chu, M., Han, G. W., Huang, X.-P., Jiang, Y., Katritch, V., Liu, W., McCorvy, J. D., Roth, B. L., Siu, F. Y., Stevens, R. C., Vardy, E., Wacker, D., Wang, C., Xu, H. E.   +14 more
core   +2 more sources

Physical Activity and BrainAGE: Exploring the Impact on Brain Health and Plasticity in Older Adults

Human Brain Mapping, Volume 46, Issue 15, October 15, 2025.
An eight‐week multi‐component physical activity intervention reduced brain age (BrainAGE) in older adults. The effect was strongest in participants with lower baseline fitness, supported by structural brain changes in motivation‐related regions. Findings support BrainAGE as a sensitive biomarker of intervention effects on brain health. ABSTRACT With an
Tannaz Saraei, Simon Schrenk, Christian Puta, Marco Herbsleb, Otto W. Witte, Christiane Frahm, Stefan Brodoehl, Kathrin Finke, Christian Gaser   +8 more
wiley   +1 more source

Structure and function of serotonin G protein-coupled receptors [PDF]

, 2015
Serotonin receptors are prevalent throughout the nervous system and the periphery, and remain one of the most lucrative and promising drug discovery targets for disorders ranging from migraine headaches to neuropsychiatric disorders such as schizophrenia
McCorvy, John D., Roth, Bryan L.
core   +2 more sources

Effects of alkaloid exposure and environment on digestion, nutrient balance, and immune function in beef cattle [PDF]

Fescue toxicosis is a complex condition in cattle caused by the consumption of ergot alkaloids produced by the endophyte (Epichloe coenophiala) that infects tall fescue [Lolium arundinaceum (Schreb.) Darbysh.].
Zeltwanger, Joshua
core   +1 more source

5-HT2B Receptor-mediated Cardiac Valvulopathy [PDF]

, 2018
5-HT2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic,
Nistala, Pallavi
core   +1 more source