Results 101 to 110 of about 331,296 (302)

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway [PDF]

Iranian Journal of Immunology, 2019
Suqian Wu, Wentao Wang, Qihua Le
doaj   +1 more source

LNC00115 Mediates Cisplatin Resistance by Regulating the miR-7/ERK Signalling Pathway in Ovarian Cancer

Cancer Management and Research, 2021
Xinyan Jiang, Yan Cheng, Yanan He, Shanshan Cong, Liyuan Sun, Di Wu, Han Wu, Guangmei Zhang The First Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of ChinaCorrespondence: Guangmei Zhang Building 2, 23 Youzheng Road ...
Jiang X, Cheng Y, He Y, Cong S, Sun L, Wu D, Wu H, Zhang G   +7 more
doaj  

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

4 open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Phosphorylation of ERK was responsible for the hypoxia-induced chemerin expression in HCAECs, which was blocked by PD98059 or ERK siRNA.

, 2016
(A and B) HCAECs were subjected to normoxia or hypoxia for different periods in the presence or absence of the inhibitors. Cell lysates were collected for western blot analysis with an antibody for total ERK and phospho-ERK.
Hang Chang (87497), Huey-Ming Lo (649172), Su-Kiat Chua (649171), Li-Ming Lien (125232), Kou-Gi Shyu (505057), Yuh-Feng Lin (398589), Bao-Wei Wang (505054)   +6 more
core   +1 more source

Measuring ERK Activity Dynamics in Single Living Cells Using FRET Biosensors. [PDF]

, 2016
Fluorescence resonance energy transfer (FRET)-based biosensors are powerful tools for measuring spatio-temporal signaling dynamics in single living cells with subcellular resolution.
Yannick Blum, Fritz, Rafael D, Olivier Pertz, Ryu, Hyunryul, Pertz, Olivier, Blum, Yannick, Hyunryul Ryu, Rafael D. Fritz, Blum Y, Ryu H, Pertz O, Fritz RD   +11 more
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

ERK was more phosphorylated in CD enterocytes.

, 2013
Immunohistochemical images of crypts and villi of intestinal biopsies from CD patients and controls stained with an antibody that recognizes the phosphorylated form of ERK 1/2 (pY-ERK) and with hematoxylin/eosin.
Merlin Nanayakkara (228892), Alessandra Gaito (473887), Roberta Kosova (473885), Riccardo Troncone (214450), Maria Vittoria Barone (178099), Mariantonia Maglio (228891), Giuliana Lania (228898), Marco Sarno (473886), Valentina Discepolo (473888), Salvatore Auricchio (214460), Renata Auricchio (214453)   +10 more
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Stab2 knockdown affects Erk phosphorylation.

, 2014
(A–D) Phosphorylated Erk expression is observed in the DA of uninjected control embryos by whole mount immunostaining (A,B), while a majority of Stab2 morphants display a reduction in arterial P-Erk expression (C,D). (E) Percentages of embryos displaying
Megan S. Rost (528811), Saulius Sumanas (12968)   +1 more
core   +1 more source