Results 121 to 130 of about 331,296 (302)

6-Bnz-cAMP prevents CSE-induced ERK phosphorylation.

, 2012
hTERT-ASM cells were lysed after being stimulated with 15% CSE, 100 µM 8-pCPT-2′-O-Me-cAMP, 500 µM 6-Bnz-cAMP or their combinations for 1 hr followed by Western blot analysis of phospho-ERK (p-ERK).
Anouk Oldenburger (183278), Harm Maarsingh (183304), Mark H. Menzen (183289), Martina Schmidt (183309), Herman Meurs (183299), Esther Jansen (183286), Wim Timens (41871), Andrew J. Halayko (183293), Sara S. Roscioni (183281)   +8 more
core   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Ludwig Erk

, 1876
LUDWIG ERK Ludwig Erk / Schultze, Karl (Public Domain) ( - ) Title page ( - ) Text ( - ) Ludwig Christian Erk (7) Hilf dir selbst, so hilft dir Gott (14) Der Liederhort (25) Anderweitige ...
Schultze, Karl
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Mechanisms Promoting ERK-Dependent Neuronal Oxidative Toxicity [PDF]

, 2004
Glutamate-induced oxidative toxicity in HT22 cells and primary immature cortical cultures provides an excellent model system for studying oxidative stress-dependent neurodegeneration.
Levinthal, David Justin
core  

Cell type specific activation of Erk.

, 2013
(A) AKR-2B and NIH 3T3 fibroblast were treated with TGF-β (2 ng/ml) for times ranging from 0 to 4 h. Cell lysates were probed with antibodies specific to phospho-Erk (P-Erk).
Jules J. E. Doré (312482), Maria Radu (312481), Chris Hough (312480)   +2 more
core   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Ishige okamurae extract suppresses osteoclastogenesis in RANKL-induced bone marrow-derived macrophages and ovariectomized mouse model

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the inhibitory effects of Ishige okamurae extract (IOE) against osteoclastogenesis in vitro and in vivo. Methods: The effects of IOE on osteoclast differentiation were examined in receptor activator of nuclear factor-KB ligand ...
Su-Hyeon Cho, Hye-Yeon Jung, Songrae Kim, You-Jee Jang, Jae-Il Park, Kil-Nam Kim   +5 more
doaj   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Liederkranz : Auswahl heiterer und ernster Gesänge für Schule, Haus und Leben / Herausgegeben von Ludwig Erk u. Wilhelm Greef.

LIEDERKRANZ : AUSWAHL HEITERER UND ERNSTER GESÄNGE FÜR SCHULE, HAUS UND LEBEN / HERAUSGEGEBEN VON LUDWIG ERK U. WILHELM GREEF. Liederkranz : Auswahl heiterer und ernster Gesänge für Schule, Haus und Leben / Herausgegeben von Ludwig Erk u. Wilhelm Greef.
Erk, Ludwig, Greef, Wilhelm
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