Results 131 to 140 of about 254,157 (265)

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

ERK autoinhibition mechanism informs a drug combination strategy. [PDF]

Protein Sci
Regev C, Jang H, Nussinov R.
europepmc   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

S100A4 Orchestrates Fibroblast Fate to Drive Fibrotic Remodeling. [PDF]

FASEB J
Li S, Cai B, Zhang X, Cai G, Zhou Y, Wagener BM, Ding Q.   +6 more
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

PACS2 Alleviates Sepsis-Induced Myopathy by Activating ERK-MAPK Signalling Pathway to Suppress ER-Phagy. [PDF]

J Cachexia Sarcopenia Muscle
Li X, Shi ZA, He F, Mu G, Wang F, Sun B, Wang X, Liu L.   +7 more
europepmc   +1 more source

PbAT: A user‐friendly R/Shiny platform for data‐driven decision support in crop improvement

Applications in Plant Sciences, EarlyView.
Abstract Premise Modern plant breeding requires robust analysis of complex, multi‐environment datasets to identify superior genotypes. Although R offers powerful statistical packages, their use often requires programming expertise. Existing graphical user interface (GUI)‐based tools are either limited in scope or not openly accessible, leaving breeders
Krishnan P. Abhijith, K. K. Vinod, Ranjith Kumar Ellur, K. T. Ravikiran, Rachit Kumar Saxena, Vignesh Muthusamy, S. Gopala Krishnan   +6 more
wiley   +1 more source

Podoplanin Antibody SZ168 Alleviates Sepsis Inflammation and Macrophage Dysregulation via ERK Signaling. [PDF]

Hum Mutat
Wang H, Heng J, Zhang Y, Cui J, Li Y, Yu S, Gu X, Lu S, Zhao Y.   +8 more
europepmc   +1 more source

Functional anatomy, jaw mechanisms, and feeding behavior of Dunkleosteus terrelli (Placodermi, Arthrodira)

The Anatomical Record, EarlyView.
A new musculoskeletal reconstruction and revision of the cranio‐mandibular anatomy of the Devonian arthrodire placoderm Dunkleosteus terrelli from a comparative and functional anatomical perspective. Dunkleosteus is a specialized arthrodire with many specializations for feeding on large vertebrates, and many of its features are part of broader ...
Russell K. Engelman, Robert K. Carr, Kate Trinajstic, Zerina Johanson, Oleg A. Lebedev   +4 more
wiley   +1 more source

ERBB3 Promotes Malignant Behaviors of Endometrial Cancer Cells with Involvement of the Ras-ERK/MAPK Signaling Pathway. [PDF]

Cancers (Basel)
Liu Y, Li H, Li X, Li M, Li Y.
europepmc   +1 more source