Results 151 to 160 of about 511,445 (325)

MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma [PDF]

, 2021
Hyuk Moon, Simon Weonsang Ro
openalex   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Histamine receptor 1 inhibition enhances antitumor therapeutic responses through extracellular signal-regulated kinase (ERK) activation in breast cancer

, 2018
Patricia Fernández‐Nogueira, Aleix Noguera‐Castells, Gemma Fuster, Leire Recalde‐Percaz, Núria Moragas, Anna López‐Plana, Estel Enreig, Patricia Jáuregui, Neus Carbó, Vanessa Almendro, Pedro Gascón, Paloma Bragado, Mario Mancino   +12 more
openalex   +1 more source

SLC25A22 promotes proliferation and metastasis by activating MAPK/ERK pathway in gallbladder cancer [PDF]

, 2019
Pengcheng Du, Haibin Liang, Xiaowei Fu, Peng Wu, Chao Wang, Haimin Chen, Bingbing Zheng, Jun Zhang, Shuanghui Hu, Rengui Zeng, Bo Liang, Fang Lü   +11 more
openalex   +1 more source

Uncoupling Metastasis and Epithelial‐to‐Mesenchymal Transition in sgP19/kRAS‐Driven Spontaneous Metastatic Liver Tumor Model

Advanced Science, EarlyView.
The article first reported that a murine mixed typical intrahepatic cholangiocarcinoma (iCCA)/sarcomatoid iCCA liver tumor model with 100% incidence of spontaneous extrahepatic metastasis and confirmed the occurrence of in mouse iCCA. Most importantly, EMT induced by the TGF‐β/ZEB1 axis does not influence tumor development or distant metastasis in this
Jingwen Wang, Zijing Xu, Lei Xu, Lishan Wang, Jiahao Geng, Xue Wang, Meng Xu, Daphne Superville, Melissa Reeves, Matthias Evert, Diego F. Calvisi, Xin Chen, Xinhua Song   +12 more
wiley   +1 more source

WT1 together with RUNX1::RUNX1T1 targets DUSP6 to dampen ERK activity in acute myeloid leukaemia [PDF]

Nan Xu, Feng‐Ting Dao, Zong‐Yan Shi, Kai Sun, Ya‐Zhen Qin   +4 more
openalex   +1 more source

The apelin-13 peptide protects the heart against apoptosis through the ERK/MAPK and PI3K/AKT signaling pathways. [PDF]

, 2020
Xuejun Wang, Li Zhang, Mengwen Feng, Hao Zhang, Jia Xu, Zijie Cheng, Lingmei Qian   +6 more
openalex   +1 more source

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Apoptotic pathway is induced with SSPYY by activation of 68kD cells membrane receptor with an increase in cytoplasmic ERK-1 and an increase in nuclear Elk-1 transcription factor to induce pancreatic cancer cell death [PDF]

, 2003
Adriana Deganutti, Carson D. Liu
openalex   +1 more source