Results 181 to 190 of about 511,445 (325)

Correction: Effects of Gamisoyo-San, a Traditional Herbal Medicine, on Antioxidant Phase II Enzymes via Akt-Erk-Nrf2 Pathway [PDF]

Su-Jin Bae, H Young Park, Sun‐Dong Park, Young‐Woo Kim   +3 more
openalex   +1 more source

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas [PDF]

, 2016
Juan Du, Anli Tong, Fen Wang, Yunying Cui, Chunyan Li, Yushi Zhang, Zhaoli Yan   +6 more
openalex   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Spots and stripes: Pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation

, 2009
Chih‐Min Lin, Ting Jiang, Ruth E. Baker, Philip K. Maini, Randall B. Widelitz, Cheng‐Ming Chuong   +5 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Inverse modeling unveils governing law of mechano-chemical dynamics of epithelial migration. [PDF]

PLoS Comput Biol
Kikuchi Y, Asakura Y, Aoki K, Kondo Y, Naoki H.   +4 more
europepmc   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Padina boryana, a brown alga from the Maldives: inhibition of α-MSH-stimulated melanogenesis via the activation of ERK in B16F10 cells

Fisheries and Aquatic Sciences, 2020
Thilina U. Jayawardena, K. K. Asanka Sanjeewa, Hyun-Soo Kim, Hyo Geun Lee, Lei Wang, Dae-Sung Lee, You-Jin Jeon   +6 more
doaj   +1 more source

Mesenchymal Stem Cells Restore Endometrial Integrity and Sustain Pregnancy via CCR7-ERK/JNK Signaling Modulation. [PDF]

Stem Cells Int
Lei Y, Gao J, Zhang N, Lin Y, Yang W, Chen Y, Wei Q, Xia J.   +7 more
europepmc   +1 more source

Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922

, 2016
Chunyan Wang, Su Guo, Jia Yu Wang, Xu Guang Yan, Margaret Farrelly, Yuan Yuan Zhang, Fen Liu, Hamed Yari, Ting La, Fu Xi Lei, Lei Jin, Xu Dong Zhang, Chen Chen Jiang   +12 more
openalex   +2 more sources