Results 251 to 260 of about 331,296 (302)
A compendium of ERK targets [PDF]
FEBS Letters, 2017 The RAF‐MEK‐ERK cascade is one of the most studied signaling pathways as it controls many vital cellular programs. There has been an immense amount of effort to determine ERK target proteins involved in regulating these programs. Classical biochemical and genetic approaches have elicited hundreds of direct ERK substrates, and with the advent of phospho‐
Florian Uhlitz, Nils Blüthgen
exaly +3 more sources
IEX‐1: a new ERK substrate involved in both ERK survival activity and ERK activation [PDF]
EMBO Journal, 2002 IEX-1 is an early response and NF-kappaB target gene implicated in the regulation of cellular viability. We show here that IEX-1 is a substrate for ERKs and that IEX-1 and ERK regulate each other's activities. IEX-1 was isolated by phosphorylation screening with active ERK2 and found subsequently phosphorylated in vivo upon ERK activation.
Françoise Porteu, Guillaume Pézeron
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
ERK and cell death: ERK location and T cell selection
The FEBS Journal, 2009The selection of functional T cells is mediated by interactions between the T cell antigen receptor and self‐peptide major histocompatibility complex expressed on thymic epithelium. These interactions either lead to survival and development or death. The T cell antigen receptor is an unusual receptor able to signal multiple cell fates.
Emma, Teixeiro, Mark A, Daniels
openaire +2 more sources
The Nuclear Translocation of ERK
2016The ERK1 and ERK2 (ERK1/2) cascade is a central signaling pathway activated by a wide variety of extracellular agents that transmit the messages of G Protein Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs). Being such a central pathway, the activity of the cascade is well regulated, including by dynamic changes of the subcellular ...
Denise A, Berti, Rony, Seger
openaire +2 more sources
Acta Histochemica, 2014
Chronic exposure to fluoride can result in a variety of adverse effects in fish. Previously we indicated that high fluoride caused damage and apoptosis in the kidneys of the common carp, Cyprinus carpio. In this study, the effects of fluoride on the expression and localization of ERK and p-ERK proteins in the ERK signaling pathway were determined using
Jianjie, Chen +7 more
openaire +2 more sources
Chronic exposure to fluoride can result in a variety of adverse effects in fish. Previously we indicated that high fluoride caused damage and apoptosis in the kidneys of the common carp, Cyprinus carpio. In this study, the effects of fluoride on the expression and localization of ERK and p-ERK proteins in the ERK signaling pathway were determined using
Jianjie, Chen +7 more
openaire +2 more sources
Blood, 2010
In this issue of Blood, Stein and colleagues present a novel mechanism by which MHC class II antibodies induce apoptosis in lymphoid malignancies. These are important findings that provide fresh insight into a common antibody target.
Erin, Hertlein, John C, Byrd
openaire +2 more sources
In this issue of Blood, Stein and colleagues present a novel mechanism by which MHC class II antibodies induce apoptosis in lymphoid malignancies. These are important findings that provide fresh insight into a common antibody target.
Erin, Hertlein, John C, Byrd
openaire +2 more sources
Role of ERK in cocaine addiction
Trends in Neurosciences, 2006Cocaine addiction is characterized by compulsive drug-taking behavior and high rates of relapse. According to recent theories, this addiction is due to drug-induced adaptations in the cellular mechanisms that underlie normal learning and memory. Such mechanisms involve signaling by extracellular signal-regulated kinase (ERK).
Lin, Lu +4 more
openaire +2 more sources
Determination of ERK Activity: Anti-phospho-ERK Antibodies and In Vitro Phosphorylation
2010The ERK signaling cascade is composed of several protein kinases that sequentially activate each other by phosphorylation. This pathway is a central component of a complex signaling network that regulates important cellular processes including proliferation, differentiation, and survival.
Shiri, Procaccia +2 more
openaire +2 more sources
Intramolecular Dephosphorylation of ERK by MKP3
Biochemistry, 2003The dual specificity mitogen-activated protein kinase phosphatase MKP3 downregulates mitogenic signaling through dephosphorylation of extracellular signal-regulated kinase (ERK). Like other MKPs, MKP3 consists of a noncatalytic N-terminal domain and a catalytic C-terminal domain.
Youngjoo, Kim +2 more
openaire +2 more sources
ERK prepares the brain for sleep
Science, 2017Neuroscience Why do we feel more tired and tend to sleep longer and more deeply after a period of sleep deprivation or after a physically or mentally active day? Mikhail et al. suggest that sleep deprivation or activity during the waking hours stimulates gene expression in a way that is dependent in part on the kinase ERK.
openaire +2 more sources