Haematologica, 2020 Erythropoiesis is one of the most efficient cellular processes in the human body producing approximately 2.5 million red blood cells every second.
Lea A. Hampton-O’Neil +5 more
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Scientific Reports, 2017 Hematopoietic ontogeny is characterized by distinct primitive and definitive erythroid lineages. Definitive erythroblasts mature and enucleate extravascularly and form a unique membrane skeleton, composed of spectrin, 4.1R-complex, and ankyrinR-complex ...
Yu-Shan Huang +10 more
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Erythroblasts Promote the Development of a Suppressive Lymphocyte Phenotype via Treg Induction and PD1 Upregulation on the Surfaces of B-Cells: A Study on the Subpopulation-Specific Features of Erythroblasts [PDF]
Current Issues in Molecular BiologyThis study identifies the novel effects of soluble factors derived from murine erythroblasts on lymphoid cell phenotypes. These effects were observed following the treatment of splenic mononuclear cells with erythroblast-conditioned media received from ...
Kirill Nazarov +3 more
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Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts. [PDF]
PLoS ONE, 2016 In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of adult γ-
Divya S Vinjamur +5 more
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Visual Detection of Malaria Parasite-Parasitized Erythroblasts in Peripheral Blood via Immunization-Based Model [PDF]
VaccinesBackground: Erythroblasts have recently been identified as host cells for malarial parasites, revealing a previously underappreciated host–parasite interaction.
Kumpei Ito +18 more
doaj +2 more sources
Parvovirus Infection Causing Aplastic Anaemia in an Immunocompetent Patient Diagnosed by Bone Marrow Aspiration Cytology [PDF]
National Journal of Laboratory Medicine, 2021 Human Parvovirus infection is associated with transient aplastic crisis as a most common complication in chronic haemolytic anaemia patients. Very few case reports are available regarding aplastic crisis in immunocompetent patients. Here the authors are
Ranjana Giri, Urmila Senapati
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Erythroblast Enucleation [PDF]
Stem Cells International, 2011 Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, likely to impart flexibility and improve the ability to ...
Ganesan Keerthivasan +2 more
openaire +4 more sources
Single-cell transcriptome sequencing reveals the mechanism of Realgar improvement on erythropoiesis in mice with myelodysplastic syndrome [PDF]
Cancer Cell InternationalMyelodysplastic syndrome (MDS) is a malignant hematologic disorder with limited curative options, primarily reliant on hematopoietic stem cell transplantation. Anemia, a prevalent symptom of MDS, has few effective treatment strategies.
Hao Xu +9 more
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Journal of Experimental Medicine, 2022 In our study, we demonstrated the functional importance of intercellular mitochondria transfer to mediate bioenergetic profiles of recipient erythroblasts to facilitate their recovery from anemic stress.
Chong Yang +7 more
semanticscholar +1 more source
Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts.
Blood, 2022 Developing erythroblasts acquire massive amounts of iron through the transferrin (Tf) cycle, which involves endocytosis, sorting, and recycling of the Tf-Tf receptor (Tfrc) complex.
Mengying Chen +9 more
semanticscholar +1 more source