Results 11 to 20 of about 21,080 (163)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

open access: yesHepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam   +10 more
wiley   +1 more source

Increased autophagy leads to decreased apoptosis during β-thalassaemic mouse and patient erythropoiesis

open access: yesScientific Reports, 2022
β-Thalassaemia results from defects in β-globin chain production, leading to ineffective erythropoiesis and subsequently to severe anaemia and other complications.
Pornthip Chaichompoo   +9 more
doaj   +1 more source

Study of phenotypic and cytotoxic properties of erythroid cells of the spleen under hematopoiesis-stimulating effects

open access: yesМедицинская иммунология, 2023
In recent years, research has revealed a wide variety of erythroid cell functions, including modulation of innate and adaptive immune responses. Anemic or hypoxic stress stimulates a physiological response in the form of stress erythropoiesis, aimed at ...
Yu. A. Shevchenko   +2 more
doaj   +1 more source

Antitumor properties of nuclear erythroid cells

open access: yesСибирский онкологический журнал, 2022
Purpose. To study suppressor and/or cytotoxic activity of the nuclear erythroid cells (NEC) against tumor cells of various origins. Material and Methods. C57Bl/6 mice and P815, L1210, B16 and L929 tumor cells were used.
V. A. Kozlov   +4 more
doaj   +1 more source

Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts

open access: yesHaematologica, 2020
Erythropoiesis is one of the most efficient cellular processes in the human body producing approximately 2.5 million red blood cells every second.
Lea A. Hampton-O’Neil   +5 more
doaj   +1 more source

Studies on reticuloendothelial system and hemato-poiesis, III. Relationship between differentiation of erythroblast and oxygen tension [PDF]

open access: yes, 1965
For the purpose to clarify the control mechanism of erythroid cell differentiation, the author observed morphologic changes in bone-marrow cells and circulating red cells in phenylhydrazine anemia of rabbits by introducing a mass of red cells into vein ...
Matsuoka, Kenichi
core   +1 more source

Studies on erythropoiesis II. In vitro studies on red cell proliferation under varied oxygen tension [PDF]

open access: yes, 1964
For the purpose to reveal the mechanism of the stimulated erythropoiesis in anemic condition, the author observed the numerical changes of the erythroblasts from normal rabbit bone marrow cultured under the environment of varied oxygen tensions, and ...
Shibata, Takashi
core   +1 more source

Vascular remodeling of the mouse yolk sac requires hemodynamic force [PDF]

open access: yes, 2007
The embryonic heart and vessels are dynamic and form and remodel while functional. Much has been learned about the genetic mechanisms underlying the development of the cardiovascular system, but we are just beginning to understand how changes in heart ...
Chen, Ju   +5 more
core   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil [PDF]

open access: yes, 1968
With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo ...
Shigehisa, Morio
core   +1 more source

Home - About - Disclaimer - Privacy