Results 11 to 20 of about 29,567 (256)

Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors

bioRxiv, 2022
Transfusion of donor-derived red blood cells (RBCs) is the most common form of cell therapy. Production of transfusion-ready cultured RBCs (cRBCs) is a promising replacement for the current fully donor-dependent therapy.
Joan Sebastián Gallego-Murillo, Giulia Iacono, L. A. van der Wielen, Emile van den Akker, M. von Lindern, S. A. Wahl   +5 more
semanticscholar   +1 more source

Production of immunoregulatory molecules by induced erythroblasts at various stages of cell differentiation

Acta Biomedica Scientifica, 2022
Introduction. Bone marrow erythroblasts produce a wide range of cytokines with opposite biological effects. This may be due to a change in the spectrum of production of immunoregulatory mediators during differentiation and small qualitative and ...
K. V. Nazarov, R. Yu. Perik-Zavodsky, M. S. Kuznetsova, Yu. G. Philippova, Yu. A. Shevchenko, V. V. Denisova, A. N. Silkov, S. V. Sennikov   +7 more
doaj   +1 more source

Environmental Nanoparticles Reach Human Fetal Brains

Biomedicines, 2022
Anthropogenic ultrafine particulate matter (UFPM) and industrial and natural nanoparticles (NPs) are ubiquitous. Normal term, preeclamptic, and postconceptional weeks(PCW) 8–15 human placentas and brains from polluted Mexican cities were analyzed by TEM ...
Lilian Calderón-Garcidueñas, Ángel Augusto Pérez-Calatayud, Angélica González-Maciel, Rafael Reynoso-Robles, Héctor G. Silva-Pereyra, Andrea Ramos-Morales, Ricardo Torres-Jardón, Candelario de Jesús Soberanes-Cerino, Raúl Carrillo-Esper, Jesús Carlos Briones-Garduño, Yazmín del Socorro Conde-Gutiérrez   +10 more
doaj   +1 more source

Mitochondria transfer from early stages of erythroblasts to their macrophage niche via tunnelling nanotubes

British Journal of Haematology, 2021
Adult erythropoiesis entails a series of well‐coordinated events that produce mature red blood cells. One of such events is the mitochondria clearance that occurs cell‐autonomously via autophagy‐dependent mechanisms.
Chong Yang, Mitsuhiro Endoh, D. Tan, A. Nakamura-Ishizu, Yuji Takihara, T. Matsumura, T. Suda   +6 more
semanticscholar   +1 more source

Mechanical Stress Induces Ca2+-Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis

International Journal of Molecular Sciences, 2021
Bioreactors are increasingly implemented for large scale cultures of various mammalian cells, which requires optimization of culture conditions. Such upscaling is also required to produce red blood cells (RBC) for transfusion and therapy purposes ...
Francesca Aglialoro, Asena Abay, N. Yağcı, M. Rab, L. Kaestner, R. van Wijk, M. von Lindern, E. van den Akker   +7 more
semanticscholar   +1 more source

MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera

Scientific Reports, 2021
Polycythaemia vera (PV) is a haematological disorder caused by an overproduction of erythroid cells. To date, the molecular mechanisms involved in the disease pathogenesis are still ambiguous.
Chartsiam Tipgomut, Archrob Khuhapinant, Marieangela C. Wilson, Saiphon Poldee, Kate J. Heesom, Chanatip Metheetrairut, Orapan Sripichai, Chalermchai Mitrpant, Jan Frayne, Kongtana Trakarnsanga   +9 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Genome-Wide Transcriptional Regulation of the Long Non-coding RNA Steroid Receptor RNA Activator in Human Erythroblasts

Frontiers in Genetics, 2020
Erythropoiesis of human hematopoietic stem cells (HSCs) maintains generation of red blood cells throughout life. However, little is known how human erythropoiesis is regulated by long non-coding RNAs (lncRNAs). By using ChIRP-seq, we report here that the
Waritta Sawaengdee, Kairong Cui, Keji Zhao, Suradej Hongeng, Suthat Fucharoen, Patompon Wongtrakoongate, Patompon Wongtrakoongate   +6 more
doaj   +1 more source

The oxygen dissociation curve of blood in COVID-19–An update

Frontiers in Medicine, 2023
An impressive effect of the infection with SARS-Co-19 is the impairment of oxygen uptake due to lung injury. The reduced oxygen diffusion may potentially be counteracted by an increase in oxygen affinity of hemoglobin.
Dieter Böning, Wolfgang M. Kuebler, Dominik Vogel, Wilhelm Bloch   +3 more
doaj   +1 more source

Generation of ‘designer erythroblasts’ lacking one or more blood group systems from CRISPR/Cas9 gene‐edited human‐induced pluripotent stem cells

Journal of Cellular and Molecular Medicine, 2021
Despite the recent advancements in transfusion medicine, red blood cell (RBC) alloimmunization remains a challenge for multiparous women and chronically transfused patients.
P. Pandey, Nanyan Zhang, B. Curtis, P. Newman, G. Denomme   +4 more
semanticscholar   +1 more source