Results 51 to 60 of about 29,567 (256)

Ultrastructural characteristics of erythroid cells in congenital dyserythropoietic anemia type II, with a focus on peripheral cisternae and double membranes

Blood Science, 2023
Peripheral cisternae and double membranes (PCDMs) in erythroid cells are a landmark of type II congenital dyserythropoietic anemia (CDA). To gain further insights into the mechanism of dyserythropoiesis, erythroblasts and erythrocytes in bone marrow were
Yong-Xin Ru, Shu-Xu Dong, Jing Liu, Brian Eyden   +3 more
doaj   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization [PDF]

, 1969
The disappearance of nucleolus has been traced in the rat erythroid cells in relation with the cell specialization under varying conditions, i. e. in anemia with or without treatment by bromouracil and aminopterin.
Shigehisa, Morio
core   +1 more source

Ferric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium

npj Regenerative Medicine, 2023
Red blood cell (RBC) generation from human pluripotent stem cells (PSCs) offers potential for innovative cell therapy in regenerative medicine as well as developmental studies.
Soo-Been Jeon, Hyebin Koh, A-Reum Han, Jieun Kim, Sunghun Lee, Jae-Ho Lee, Seung-Soon Im, Young-sup Yoon, Jong-Hee Lee, Ji Yoon Lee   +9 more
doaj   +1 more source

Early Development of Definitive Erythroblasts from Human Pluripotent Stem Cells Defined by Expression of Glycophorin A/CD235a, CD34, and CD36

Stem Cell Reports, 2016
The development of human erythroid cells has been mostly examined in models of adult hematopoiesis, while their early derivation during embryonic and fetal stages is largely unknown.
Bin Mao, Shu Huang, Xulin Lu, Wencui Sun, Ya Zhou, Xu Pan, Jinfeng Yu, Mowen Lai, Bo Chen, Qiongxiu Zhou, Song Mao, Guohui Bian, Jiaxi Zhou, Tatsutoshi Nakahata, Feng Ma   +14 more
doaj   +1 more source

Comprehensive Characterization and Global Transcriptome Analysis of Human Fetal Liver Terminal Erythropoiesis

Genomics, Proteomics & Bioinformatics, 2023
The fetal liver (FL) is the key erythropoietic organ during fetal development, but knowledge on human FL erythropoiesis is very limited. In this study, we sorted primary erythroblasts from FL cells and performed RNA sequencing (RNA-seq) analyses.
Yongshuai Han, Shihui Wang, Yaomei Wang, Yumin Huang, Chengjie Gao, Xinhua Guo, Lixiang Chen, Huizhi Zhao, Xiuli An   +8 more
doaj   +1 more source

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts

Haematologica, 2019
Telomerase is a ribonucleoprotein complex that maintains the length and integrity of telomeres, and thereby enables cellular proliferation. Understanding the regulation of telomerase in hematopoietic cells is relevant to the pathogenesis of leukemia, in ...
L. A. Richards, A. Kumari, K. Knezevic, J. Thoms, Georg von Jonquieres, C. Napier, Zara Ali, R. O'Brien, Jonathon Marks-Bluth, M. Maritz, H. Pickett, Jonathan I. Morris, J. Pimanda, K. MacKenzie   +13 more
semanticscholar   +1 more source

Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]

, 2015
Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica, Fatica, Alessandro, Morlando, Mariangela   +2 more
core   +2 more sources

Importância clínica da dosagem de lactato e contagem de eritroblastos no sangue colhido no segmento placentário da veia umbilical para o diagnóstico de hipóxia-isquemia em prematuros Clinical value of lactate measurement and nucleated red blood cell counts in the placental segment of the umbilical vein of premature newborns for diagnosis of hypoxia-ischemia

Jornal de Pediatria, 2007
OBJETIVO: Determinar a validade clínica das dosagens de lactato e contagem de eritroblastos quando comparados com o excesso de bases (EB) em sangue do segmento placentário da veia umbilical de prematuros. MÉTODOS: foram colhidas amostras de 25 prematuros,
Yvi Gea, Orlei Araujo, Luiz Vicente R. Silva   +2 more
doaj   +1 more source

ISG15 modulates development of the erythroid lineage. [PDF]

PLoS ONE, 2011
Activation of erythropoietin receptor allows erythroblasts to generate erythrocytes. In a search for genes that are up-regulated during this differentiation process, we have identified ISG15 as being induced during late erythroid differentiation.
Ana Leticia Maragno, Martine Pironin, Hélène Alcalde, Xiuli Cong, Klaus-Peter Knobeloch, Frederic Tangy, Dong-Er Zhang, Jacques Ghysdael, Christine Tran Quang   +8 more
doaj   +1 more source

CIRCULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS AND ERYTHROBLASTS COUNTING IS INCREASED IN PATIENTS WITH SICKLE CELL ANEMIA

Hematology, Transfusion and Cell Therapy, 2023
Due to the challenges associated with accessing bone marrow samples from individuals with sickle cell anemia (SCA), hematopoiesis in the context of this disease remains less studied compared to other pathologies.
J Milhomens, A Godard, J Grenier, M De-Grandis, DT Covas, W El-Nemer, S Kashima   +6 more
doaj   +1 more source