Results 1 to 10 of about 91,872 (258)

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation [PDF]

Nature Cell Biology, 2017
Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Yuannyu Zhang, Robert A J Signer, Dan Leslie Li   +2 more
exaly   +3 more sources

Histone modifications in the regulation of erythropoiesis [PDF]

Annals of Medicine
Introduction The pathogenesis of anemia and other erythroid dysphasia are mains poorly understood, primarily due to limited knowledge about the differentiation processes and regulatory mechanisms governing erythropoiesis.
Xiuyun Wu, Hongdi Xu, Erxi Xia, Linru Gao, Yan Hou, Lei Sun, Hengchao Zhang, Ying Cheng   +7 more
doaj   +2 more sources

TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice through the regulation of iron metabolism of macrophages with IFN-γ

Frontiers in Immunology, 2023
Splenomegaly is a prominent clinical manifestation of malaria and the causes remain incompletely clear. Anemia is induced in malaria and extramedullary splenic erythropoiesis is compensation for the loss of erythrocytes.
Jiajie Li, Lin Liu, Junmin Xing, Dianhui Chen, Chao Fang, Feng Mo, Yumei Gong, Zhengrong Tan, Guikuan Liang, Wei Xiao, Shanni Tang, Haixia Wei, Shan Zhao, Hongyan Xie, Xingfei Pan, Xiaomao Yin, Jun Huang, Jun Huang, Jun Huang   +18 more
doaj   +1 more source

Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms

Frontiers in Physiology, 2023
Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen.
Baiye Ruan, Robert F. Paulson, Robert F. Paulson   +2 more
doaj   +1 more source

Post-transcriptional regulation of erythropoiesis

Blood Science, 2023
Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining normal body functions. Its strict regulation is necessary to prevent a variety of blood diseases.
Yanan Li, Haihang Zhang, Bin Hu, Pan Wang, Wei Wang, Jing Liu   +5 more
doaj   +1 more source

Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice. [PDF]

PLoS ONE, 2015
Anemia is a common complication of cancer; a role of spleen in tumor-stress erythropoiesis has been suggested. However, the molecular mechanisms involved in the splenic erythropoiesis following tumor maintenance remain poorly understood.
Min Liu, Xing Jin, Xigan He, Ling Pan, Xiumei Zhang, Yunxue Zhao   +5 more
doaj   +1 more source

Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis

Biomolecules, 2023
The cytokine-inducible SH2 domain-containing (CISH) protein was the first member of the suppressor of cytokine signaling (SOCS) family of negative feedback regulators discovered, being identified in vitro as an inducible inhibitor of erythropoietin (EPO)
Saeed Maymand, Asha L. Lakkavaram, Wasan Naser, Parisa Rasighaemi, Daniel Dlugolenski, Clifford Liongue, John Stambas, Tania F. de Koning-Ward, Alister C. Ward   +8 more
doaj   +1 more source

Stress Erythropoiesis is a Key Inflammatory Response

Cells, 2020
Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen.
Robert F. Paulson, Baiye Ruan, Siyang Hao, Yuanting Chen   +3 more
doaj   +1 more source

Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation

Haematologica, 2023
Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive complex 2 (PRC2) that catalyzes H3K27 tri-methylation. Aberrant expression and loss-of-function mutations of EZH2 have been demonstrated to be tightly associated ...
Mengjia Li, Donghao Liu, Fumin Xue, Hengchao Zhang, Qianqian Yang, Lei Sun, Xiaoli Qu, Xiuyun Wu, Huizhi Zhao, Jing Liu, Qiaozhen Kang, Ting Wang, Xiuli An, Lixiang Chen   +13 more
doaj   +1 more source

Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men [PDF]

, 2013
<p>Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (v˙ O2 max).</p> <p>Purpose: This study defined the time course of changes in Hbmass, v˙ O2 max as well as running time trial ...
A Lucia, AJ Brien, B Berglund, BD Levine, C Ahlgrim, C Lundby, C Lundby, C Lundby, CC Chang, CP Alfrey, D Boning, Diresibachew H. Wondimu, DL Costill, DP Wilkerson, Elias T. Zambidis, Evangelia Daskalaki, G Banfi, G Ninot, G Russell, GP Millet, H Ehrenreich, I Mujika, JD Belcher, JJ Thomsen, JM Kirkeberg, John D. McClure, Jérôme Durussel, K Heinicke, K Miskowiak, KI Birkeland, L Rice, L Rice, M Audran, M Brines, Martin Anderson, Neal Padmanabhan, NV Olsen, P Connes, P Rasmussen, PB Laursen, R Parisotto, Rajan K. Patel, RJ Shephard, RR Engel, RS Franco, SW Ryter, TD Noakes, TD Noakes, Tushar Chatterji, W Jelkmann, W Schmidt, Yannis P. Pitsiladis   +51 more
core   +15 more sources