Results 1 to 10 of about 79,234 (272)
Histone modifications in the regulation of erythropoiesis [PDF]
Annals of MedicineIntroduction The pathogenesis of anemia and other erythroid dysphasia are mains poorly understood, primarily due to limited knowledge about the differentiation processes and regulatory mechanisms governing erythropoiesis.
Xiuyun Wu +7 more
doaj +2 more sources
Frontiers in Immunology, 2023 Splenomegaly is a prominent clinical manifestation of malaria and the causes remain incompletely clear. Anemia is induced in malaria and extramedullary splenic erythropoiesis is compensation for the loss of erythrocytes.
Jiajie Li +18 more
doaj +1 more source
Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms
Frontiers in Physiology, 2023 Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen.
Baiye Ruan +2 more
doaj +1 more source
Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice. [PDF]
PLoS ONE, 2015 Anemia is a common complication of cancer; a role of spleen in tumor-stress erythropoiesis has been suggested. However, the molecular mechanisms involved in the splenic erythropoiesis following tumor maintenance remain poorly understood.
Min Liu +5 more
doaj +1 more source
Post-transcriptional regulation of erythropoiesis
Blood Science, 2023 Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining normal body functions. Its strict regulation is necessary to prevent a variety of blood diseases.
Yanan Li +5 more
doaj +1 more source
Networking erythropoiesis [PDF]
Journal of Experimental Medicine, 2010 A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene ...
Kerenyi, Marc A., Orkin, Stuart
openaire +3 more sources
MIF contributes to Trypanosoma brucei associated immunopathogenicity development [PDF]
, 2014 African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The pathogenicity associated with this disease involves a persistent inflammatory response, whereby M1-type ...
Beschin, Alain +11 more
core +9 more sources
Stress Erythropoiesis is a Key Inflammatory Response
Cells, 2020 Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen.
Robert F. Paulson +3 more
doaj +1 more source
Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis
Biomolecules, 2023 The cytokine-inducible SH2 domain-containing (CISH) protein was the first member of the suppressor of cytokine signaling (SOCS) family of negative feedback regulators discovered, being identified in vitro as an inducible inhibitor of erythropoietin (EPO)
Saeed Maymand +8 more
doaj +1 more source
Erythropoiesis in preleukemia [PDF]
Blood, 1978 Bone marrow cells from seven patients with preleukemia and two with erythroleukemia were cultured in vitro to characterize erythropoiesis and erythropoietin responsiveness in these disorders. The methylcellulose plate technique was used to clone erythroid progenitors, and the results were compared to data obtained from studies on five healthy ...
David W. Golde +2 more
openaire +4 more sources