Results 1 to 10 of about 121,038 (379)
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation [PDF]
Nature Cell Biology, 2017 Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Yuannyu Zhang +2 more
exaly +4 more sources
Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms
Frontiers in Physiology, 2023 Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen.
Baiye Ruan +2 more
doaj +2 more sources
Stress Erythropoiesis is a Key Inflammatory Response
Cells, 2020 Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen.
Robert F. Paulson +3 more
doaj +2 more sources
Erythropoiesis: insights into pathophysiology and treatments in 2017
Molecular Medicine, 2018 Erythropoiesis is a tightly-regulated and complex process originating in the bone marrow from a multipotent stem cell and terminating in a mature, enucleated erythrocyte.
Andrea Zivot +3 more
doaj +2 more sources
Frontiers in Immunology, 2023 Splenomegaly is a prominent clinical manifestation of malaria and the causes remain incompletely clear. Anemia is induced in malaria and extramedullary splenic erythropoiesis is compensation for the loss of erythrocytes.
Jiajie Li +18 more
doaj +1 more source
Post-transcriptional regulation of erythropoiesis
Blood Science, 2023 Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining normal body functions. Its strict regulation is necessary to prevent a variety of blood diseases.
Yanan Li +5 more
doaj +1 more source
Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice. [PDF]
PLoS ONE, 2015 Anemia is a common complication of cancer; a role of spleen in tumor-stress erythropoiesis has been suggested. However, the molecular mechanisms involved in the splenic erythropoiesis following tumor maintenance remain poorly understood.
Min Liu +5 more
doaj +1 more source
Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis
Biomolecules, 2023 The cytokine-inducible SH2 domain-containing (CISH) protein was the first member of the suppressor of cytokine signaling (SOCS) family of negative feedback regulators discovered, being identified in vitro as an inducible inhibitor of erythropoietin (EPO)
Saeed Maymand +8 more
doaj +1 more source
Haematologica, 2016 Iron overload results in significant morbidity and mortality in β-thalassemic patients. Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepcidin have therapeutic potential.
Huiyong Chen +13 more
doaj +1 more source
Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
, 2014 Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
core +1 more source