Results 101 to 110 of about 79,234 (272)

What Does Iron Mean to an Oligodendrocyte?

Glia, EarlyView.
ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions. The brain has the highest rate of energy consumption, and within the brain, oligodendrocytes have the highest level of oxidative metabolism per volume. Oligodendrocytes also stain the strongest for iron.
Quinn W. Wade, James R. Connor
wiley   +1 more source

The Shape Shifting Story of Reticulocyte Maturation

Frontiers in Physiology, 2018
The final steps of erythropoiesis involve unique cellular processes including enucleation and reorganization of membrane proteins and the cytoskeleton to produce biconcave erythrocytes. Surprisingly this process is still poorly understood.
Elina Ovchynnikova, Elina Ovchynnikova, Francesca Aglialoro, Francesca Aglialoro, Marieke von Lindern, Marieke von Lindern, Emile van den Akker, Emile van den Akker   +7 more
doaj   +1 more source

Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]

, 1990
In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias, Sangiorgi, Frank, Woods, Catherine M.   +2 more
core  

Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice. [PDF]

, 2020
BACKGROUND:Polychlorinated biphenyls (PCBs) are environmental toxicants; PCB exposure has been associated with adverse effects on wildlife and humans. However, the mechanisms underlying these adverse effects are not fully understood.
Ambrosio, Maria Elena, Blumberg, Bruce, Egusquiza, Riann Jenay, Kay, Kaelen Marie, Lehmler, Hans-Joachim, Wang, Shuyi Gin, Zhang, Chunyun   +6 more
core  

Hepcidin and iron homeostasis during pregnancy. [PDF]

, 2014
Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke, Day, Jessica, Koenig, Mary Dawn, Nemeth, Elizabeta, Tussing-Humphreys, Lisa   +4 more
core   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, EarlyView.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Primitive erythropoiesis in early chick embryogenesis. II. Correlation between hemoglobin synthesis and the mitotic history. [PDF]

, 1971
Primitive erythroblasts in the circulating blood of the chick embryo continue to divide while synthesizing hemoglobin (Hb). Hb measurements on successive generations of erythroblasts show that there is a progressive increase in the Hb content of both ...
Campbell, G le M, Holtzer, H, Mayall, BH, Weintraub, H   +3 more
core   +1 more source

Erythropoiesis in vitro.

The Keio Journal of Medicine, 1977
Various culture systems are now available to study erythropoiesis in vitro. These include suspension and cloning culture techniques. Suspension culture techniques are frequently used for studying biochemical changes in erythroid cells, while cloning culture techniques are suited for investigating the nature of erythroid stem cells.
Junzo Kaneko, Junzo Kaneko
openaire   +4 more sources

Reference Intervals of Hematological Parameters Among Healthy Adults in Northern Sudan: A Community‐Based Cross‐Sectional Study

Journal of Clinical Laboratory Analysis, EarlyView.
Two hundred fifty‐three adults were enrolled in a cross‐sectional study conducted in Northern Sudan. The RVs of hemoglobin 9.71–16.10 g/dL, red blood cells (RBC) 3.66–5.79 × 106/mm3, hematocrit (HCT) 28.02%–46.75%, mean corpuscular volume (MCV) 64.02–95.65 fL, mean corpuscular hemoglobin (MCH) 21.57–33.80 pg, mean corpuscular hemoglobin concentration ...
Mohamed F. Lutfi, Ahmed Ali Hassan, Ishag Adam   +2 more
wiley   +1 more source

Advances in the generation of erythrocytes from stem cells in vitro

Hematology
Red blood cell transfusion is the main treatment to improve anemia caused by many reasons and has important clinical application value. However, the supply of red blood cells at home and abroad is currently very tight.
Yating Ling, Hailin Du, Yu Zhang, Qiang Fu, Chengtao He   +4 more
doaj   +1 more source