Results 11 to 20 of about 94,345 (348)

IL-10 Plays a Critical Role in Mitigating Acute Anaemia Development During African Trypanosome Infection [PDF]

Pathogens
During the first week of T. b. brucei infection, pro-inflammatory IFN-γ production drives acute anaemia by promoting red blood cell clearance by activated macrophages in concert with insufficient bone marrow compensation.
Maida Živalj, Anaïs St. Martin, Patrick De Baetselier, Liudmyla Maksymova, Fara Berghmans, Louis Boon, Jo A. Van Ginderachter, Stefan Magez, Carl De Trez, Benoit Stijlemans   +9 more
doaj   +2 more sources

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation [PDF]

Nature Cell Biology, 2017
Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Yuannyu Zhang, Robert A J Signer, Dan Leslie Li   +2 more
exaly   +3 more sources

TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice through the regulation of iron metabolism of macrophages with IFN-γ

Frontiers in Immunology, 2023
Splenomegaly is a prominent clinical manifestation of malaria and the causes remain incompletely clear. Anemia is induced in malaria and extramedullary splenic erythropoiesis is compensation for the loss of erythrocytes.
Jiajie Li, Lin Liu, Junmin Xing, Dianhui Chen, Chao Fang, Feng Mo, Yumei Gong, Zhengrong Tan, Guikuan Liang, Wei Xiao, Shanni Tang, Haixia Wei, Shan Zhao, Hongyan Xie, Xingfei Pan, Xiaomao Yin, Jun Huang, Jun Huang, Jun Huang   +18 more
doaj   +1 more source

Networking erythropoiesis [PDF]

Journal of Experimental Medicine, 2010
A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene ...
Kerenyi, Marc A., Orkin, Stuart
openaire   +3 more sources

Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms

Frontiers in Physiology, 2023
Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen.
Baiye Ruan, Robert F. Paulson, Robert F. Paulson   +2 more
doaj   +1 more source

Post-transcriptional regulation of erythropoiesis

Blood Science, 2023
Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining normal body functions. Its strict regulation is necessary to prevent a variety of blood diseases.
Yanan Li, Haihang Zhang, Bin Hu, Pan Wang, Wei Wang, Jing Liu   +5 more
doaj   +1 more source

Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice. [PDF]

PLoS ONE, 2015
Anemia is a common complication of cancer; a role of spleen in tumor-stress erythropoiesis has been suggested. However, the molecular mechanisms involved in the splenic erythropoiesis following tumor maintenance remain poorly understood.
Min Liu, Xing Jin, Xigan He, Ling Pan, Xiumei Zhang, Yunxue Zhao   +5 more
doaj   +1 more source

Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis

Biomolecules, 2023
The cytokine-inducible SH2 domain-containing (CISH) protein was the first member of the suppressor of cytokine signaling (SOCS) family of negative feedback regulators discovered, being identified in vitro as an inducible inhibitor of erythropoietin (EPO)
Saeed Maymand, Asha L. Lakkavaram, Wasan Naser, Parisa Rasighaemi, Daniel Dlugolenski, Clifford Liongue, John Stambas, Tania F. de Koning-Ward, Alister C. Ward   +8 more
doaj   +1 more source

Stress Erythropoiesis is a Key Inflammatory Response

Cells, 2020
Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen.
Robert F. Paulson, Baiye Ruan, Siyang Hao, Yuanting Chen   +3 more
doaj   +1 more source

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

Haematologica, 2016
Iron overload results in significant morbidity and mortality in β-thalassemic patients. Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepcidin have therapeutic potential.
Huiyong Chen, Tenzin Choesang, Huihui Li, Shuming Sun, Petra Pham, Weili Bao, Maria Feola, Mark Westerman, Guiyuan Li, Antonia Follenzi, Lionel Blanc, Stefano Rivella, Robert E. Fleming, Yelena Z. Ginzburg   +13 more
doaj   +1 more source