Anemia of chronic disease is a multifactorial disorder, resulting mainly from inflammation-driven reticuloendothelial iron retention, impaired erythropoiesis, and reduced biological activity of erythropoietin.
Milan Theurl +13 more
doaj +1 more source
Adrenergic Modulation of Erythropoiesis After Trauma
Severe traumatic injury results in a cascade of systemic changes which negatively affect normal erythropoiesis. Immediately after injury, acute blood loss leads to anemia, however, patients can remain anemic for as long as 6 months after injury. Research
Jennifer A. Munley +2 more
doaj +1 more source
Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis [PDF]
Erythropoiesis under basal conditions involves the continuous production of new erythrocytes at a constant rate. During the adult period, erythropoiesis takes place primarily in the bone marrow and has a substantial capacity.
Momčilović Sanja +2 more
doaj +1 more source
Adding epoetin alfa to intense dose-dense adjuvant chemotherapy for breast cancer : randomized clinical trial [PDF]
BACKGROUND: The AGO-ETC trial compared 5-year relapse-free survival of intense dose-dense (IDD) sequential chemotherapy with epirubicin (E), paclitaxel (T), and cyclophosphamide (C) (IDD-ETC) every 2 weeks vs conventional scheduled epirubicin ...
Bois, Andreas du +13 more
core +1 more source
Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases [PDF]
Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors.
Adimy, Mostafa +2 more
core +5 more sources
Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men [PDF]
<p>Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (v˙ O2 max).</p> <p>Purpose: This study defined the time course of changes in Hbmass, v˙ O2 max as well as running time trial ...
A Lucia +51 more
core +11 more sources
Patient and physician characteristics associated with use of erythropoiesis-stimulating agents in myelodysplastic syndrome patients have not yet been described.
Amy J. Davidoff +7 more
doaj +1 more source
The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]
For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core +1 more source
Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber +36 more
core +1 more source
The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages
Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the machinery through which these dead cells are recognized and phagocytically cleared is incompletely understood.
Lidia Jiménez-García +6 more
doaj +1 more source

