Results 21 to 30 of about 121,038 (379)

Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation

Haematologica, 2023
Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive complex 2 (PRC2) that catalyzes H3K27 tri-methylation. Aberrant expression and loss-of-function mutations of EZH2 have been demonstrated to be tightly associated ...
Mengjia Li, Donghao Liu, Fumin Xue, Hengchao Zhang, Qianqian Yang, Lei Sun, Xiaoli Qu, Xiuyun Wu, Huizhi Zhao, Jing Liu, Qiaozhen Kang, Ting Wang, Xiuli An, Lixiang Chen   +13 more
doaj   +1 more source

Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model scat

Frontiers in Physiology, 2018
RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3.
Emily S. Hartman, Elena C. Brindley, Elena C. Brindley, Julien Papoin, Steven L. Ciciotte, Yue Zhao, Luanne L. Peters, Lionel Blanc, Lionel Blanc   +8 more
doaj   +1 more source

Erythropoiesis and Hyperoxia

Experimental Biology and Medicine, 1973
SummaryExposure to a 50% oxygen environment produced a decrease in erythropoiesis which was paralleled by a decrease in plasma erythropoietic stimulating activity. Similar results were obtained following exposure to a 100% oxygen environment. Marrow depression produced by hyperoxia could be reversed by erythropoietic stimulants.
J W, Fletcher, N I, Gallagher, M A, Warnecke, R M, Donati   +3 more
openaire   +2 more sources

Research advances in erythrocyte regeneration sources and methods in vitro

Cell Regeneration, 2018
Erythrocytes (red blood cells, RBCs) facilitate gas exchange in the lungs and transport oxygen to the tissues. The human body must maintain erythrocyte regeneration to support metabolically active cells and tissues.
Shuming Sun, Yuanliang Peng, Jing Liu
doaj   +1 more source

Regulation of erythropoiesis: emerging concepts and therapeutic implications

Hematology, 2023
The process of erythropoiesis is complex and involves the transfer of cells from the yolk sac to the fetal hepar and, ultimately, to the bone marrow during embryonic development.
Pu Tang, Huaquan Wang
doaj   +1 more source

MIF contributes to Trypanosoma brucei associated immunopathogenicity development [PDF]

, 2014
African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The pathogenicity associated with this disease involves a persistent inflammatory response, whereby M1-type ...
Beschin, Alain, Brys, Lea, Bucala, Richard, Caljon, Guy, De Baetselier, Patrick, Leng, Lin, Raes, Geert, Sparkes, Amanda, Stijlemans, Benoit, Van Den Abbeele, Jan, Van Ginderachter, Jo A, Vansintjan, Liese   +11 more
core   +4 more sources

Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats

Haematologica, 2014
Anemia of chronic disease is a multifactorial disorder, resulting mainly from inflammation-driven reticuloendothelial iron retention, impaired erythropoiesis, and reduced biological activity of erythropoietin.
Milan Theurl, Manfred Nairz, Andrea Schroll, Thomas Sonnweber, Malte Asshoff, David Haschka, Markus Seifert, Wolfgang Willenbacher, Doris Wilflingseder, Wilfried Posch, Anthony T. Murphy, Derrick R. Witcher, Igor Theurl, Günter Weiss   +13 more
doaj   +1 more source

Adrenergic Modulation of Erythropoiesis After Trauma

Frontiers in Physiology, 2022
Severe traumatic injury results in a cascade of systemic changes which negatively affect normal erythropoiesis. Immediately after injury, acute blood loss leads to anemia, however, patients can remain anemic for as long as 6 months after injury. Research
Jennifer A. Munley, Lauren S. Kelly, Alicia M. Mohr   +2 more
doaj   +1 more source

Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men [PDF]

, 2013
<p>Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (v˙ O2 max).</p> <p>Purpose: This study defined the time course of changes in Hbmass, v˙ O2 max as well as running time trial ...
A Lucia, AJ Brien, B Berglund, BD Levine, C Ahlgrim, C Lundby, C Lundby, C Lundby, CC Chang, CP Alfrey, D Boning, Diresibachew H. Wondimu, DL Costill, DP Wilkerson, Elias T. Zambidis, Evangelia Daskalaki, G Banfi, G Ninot, G Russell, GP Millet, H Ehrenreich, I Mujika, JD Belcher, JJ Thomsen, JM Kirkeberg, John D. McClure, Jérôme Durussel, K Heinicke, K Miskowiak, KI Birkeland, L Rice, L Rice, M Audran, M Brines, Martin Anderson, Neal Padmanabhan, NV Olsen, P Connes, P Rasmussen, PB Laursen, R Parisotto, Rajan K. Patel, RJ Shephard, RR Engel, RS Franco, SW Ryter, TD Noakes, TD Noakes, Tushar Chatterji, W Jelkmann, W Schmidt, Yannis P. Pitsiladis   +51 more
core   +11 more sources

Adding epoetin alfa to intense dose-dense adjuvant chemotherapy for breast cancer : randomized clinical trial [PDF]

, 2013
BACKGROUND: The AGO-ETC trial compared 5-year relapse-free survival of intense dose-dense (IDD) sequential chemotherapy with epirubicin (E), paclitaxel (T), and cyclophosphamide (C) (IDD-ETC) every 2 weeks vs conventional scheduled epirubicin ...
Bois, Andreas du, Hinke, Axel, Huober, Jens, Jackisch, Christian, Kreienberg, Rolf, Kuhn, Walther, Kurbacher, Christian, Lueck, Hans-Joachim, Moebus, Volker, Nitz, Ulrike, Runnebaum, Ingo B., Schneeweiss, Andreas, Thomssen, Christoph, Untch, Michael   +13 more
core   +1 more source