Results 31 to 40 of about 91,872 (258)

Erythropoiesis and Hyperoxia

Experimental Biology and Medicine, 1973
SummaryExposure to a 50% oxygen environment produced a decrease in erythropoiesis which was paralleled by a decrease in plasma erythropoietic stimulating activity. Similar results were obtained following exposure to a 100% oxygen environment. Marrow depression produced by hyperoxia could be reversed by erythropoietic stimulants.
Robert M. Donati, James W. Fletcher, N. I. Gallagher, M. A. Warnecke   +3 more
openaire   +3 more sources

Fine‐Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation

Advanced Science, 2022
Lipid metabolism is essential for stemness maintenance, self‐renewal, and differentiation of stem cells, however, the regulatory function of cholesterol metabolism in erythroid differentiation is poorly studied.
Zhiyuan Lu, Lixia Huang, Yanxia Li, Yan Xu, Ruihao Zhang, Qian Zhou, Qi Sun, Yi Lu, Junjie Chen, Yuemao Shen, Jian Li, Baobing Zhao   +11 more
doaj   +1 more source

Krüppel-Like Factor 1: A Pivotal Gene Regulator in Erythropoiesis

Cells, 2022
Krüppel-like factor 1 (KLF1) plays a crucial role in erythropoiesis. In-depth studies conducted on mice and humans have highlighted its importance in erythroid lineage commitment, terminal erythropoiesis progression and the switching of globin genes from
Cristian Antonio Caria, Valeria Faà, Maria Serafina Ristaldi   +2 more
doaj   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber, Boer, Chung, Decker, Gabrilove, Gonzalez, Goodnough, Gotoh, Haq, Jain, Jain, Jonk, Kaptein, Kirito, Kirito, Kirito, Lim, Millot, Miyazaki, Mulcahy, Ng, Schuringa, Schuringa, Schuringa, Smithgall, Socolovsky, Teglund, Tilbrook, Turkson, Watowich, Wen, Wen, Woetmann, Yokogami, Youssoufian, Yu, Zhang   +36 more
core   +1 more source

Erythropoiesis in Hypothyroidism

Experimental Biology and Medicine, 1973
SummaryThe purpose of this study was to clarify the role which disordered iron metabolism and alterations in the homeostatic regulation of red cell production play in hypothyroid anemia.
James W. Fletcher, Robert M. Donati, M. A. Warnecke, N. I. Gallagher   +3 more
openaire   +2 more sources

The role of cyclic nucleotide on fetal and neonantal erythropoiesis [PDF]

, 1974
For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows
Tada, Hiroshi
core   +1 more source

Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy. [PDF]

, 2002
In part A of this study, patients were randomised to cohorts receiving darbepoetin alfa at doses of 0.5 to 8.0 m.c.g x kg(-1) x wk(-1) or to a control group receiving epoetin alfa at an initial dose of 150 U x kg(-1) three times weekly.
Armstrong, S, Colowick, AB, Glaspy, JA, Jadeja, JS, Justice, G, Kessler, J, O'Byrne, J, Richards, D, Rossi, G, Schwartzberg, L, Tchekmedyian, NS   +10 more
core   +2 more sources

A Single 60.000 IU Dose of Erythropoietin Does Not Improve Short-Term Aerobic Exercise Performance in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial

Frontiers in Physiology, 2020
Erythropoietin (EPO) boosts exercise performance through increase in oxygen transport capacity following regular administration of EPO but preclinical study results suggest that single high dose of EPO also may improve exercise capacity.
Thomas Haider, Thomas Haider, Thomas Haider, Victor Diaz, Jamie Albert, Maria Alvarez-Sanchez, Markus Thiersch, Marco Maggiorini, Matthias P. Hilty, Christina M. Spengler, Christina M. Spengler, Max Gassmann, Max Gassmann   +12 more
doaj   +1 more source

Erythroblastic Island Macrophages Shape Normal Erythropoiesis and Drive Associated Disorders in Erythroid Hematopoietic Diseases

Frontiers in Cell and Developmental Biology, 2021
Erythroblastic islands (EBIs), discovered more than 60 years ago, are specialized microenvironments for erythropoiesis. This island consists of a central macrophage with surrounding developing erythroid cells.
Wei Li, Rongqun Guo, Yongping Song, Zhongxing Jiang   +3 more
doaj   +1 more source

Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling

Biology, 2023
Ribosomes are the vital molecular machine for protein translation in a cell. Defects in several nucleolar proteins have been observed in human ribosomopathies.
Fang Liang, Xiaochan Lu, Biyu Wu, Yexin Yang, Wei Qin   +4 more
doaj   +1 more source