Results 31 to 40 of about 121,038 (379)
Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis [PDF]
Medicinski PodmladakErythropoiesis under basal conditions involves the continuous production of new erythrocytes at a constant rate. During the adult period, erythropoiesis takes place primarily in the bone marrow and has a substantial capacity.
Momčilović Sanja +2 more
doaj +1 more source
Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy. [PDF]
, 2002 In part A of this study, patients were randomised to cohorts receiving darbepoetin alfa at doses of 0.5 to 8.0 m.c.g x kg(-1) x wk(-1) or to a control group receiving epoetin alfa at an initial dose of 150 U x kg(-1) three times weekly.
Armstrong, S +10 more
core +2 more sources
Erythropoiesis in Hypothyroidism
Experimental Biology and Medicine, 1973 SummaryThe purpose of this study was to clarify the role which disordered iron metabolism and alterations in the homeostatic regulation of red cell production play in hypothyroid anemia.
R M, Donati +3 more
openaire +2 more sources
Networking erythropoiesis [PDF]
Journal of Experimental Medicine, 2010 A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene ...
Kerenyi, Marc A., Orkin, Stuart
openaire +3 more sources
NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.
Haematologica, 2020 The Nuclear Receptor Coactivator 4 (NCOA4) promotes ferritin degradation and Ncoa4-ko mice in C57BL/6 background show microcytosis and mild anemia, aggravated by iron deficiency. To understand tissue specific contribution of NCOA4-mediated ferritinophagy
A. Nai +10 more
semanticscholar +1 more source
Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases [PDF]
, 2006 Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors.
Adimy, Mostafa +2 more
core +5 more sources
Current Opinion in Hematology, 2019 Purpose of review Erythropoiesis is a complex multistep process going from committed erythroid progenitors to mature red cells. Although recent advances allow the characterization of some components of erythropoiesis, much still remains to be investigated particularly on stress erythropoiesis.
Matte A., De Franceschi L.
openaire +3 more sources
International Journal of Integrated Health Sciences, 2021 Objective: To determine the mechanism of erythropoiesis that led to anemia using the Immature Reticulocyte Fraction (IRF) parameter in various clinical phases of dengue fever.
Amaylia Oehadian +5 more
doaj +1 more source
Erythropoiesis in preleukemia [PDF]
Blood, 1978 Bone marrow cells from seven patients with preleukemia and two with erythroleukemia were cultured in vitro to characterize erythropoiesis and erythropoietin responsiveness in these disorders. The methylcellulose plate technique was used to clone erythroid progenitors, and the results were compared to data obtained from studies on five healthy ...
H P, Koeffler, M J, Cline, D W, Golde
openaire +3 more sources
Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis
International Journal of Molecular Sciences, 2020 Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO ...
Deepika Watts +6 more
semanticscholar +1 more source