Results 51 to 60 of about 121,038 (379)
Physiological and Aberrant γ-Globin Transcription During Development
Frontiers in Cell and Developmental Biology, 2021 The expression of the fetal Gγ- and Aγ-globin genes in normal development is confined to the fetal period, where two γ-globin chains assemble with two α-globin chains to form α2γ2 tetramers (HbF). HbF sustains oxygen delivery to tissues until birth, when
Gloria Barbarani +4 more
doaj +1 more source
The use of genes for performance enhancement: doping or therapy? [PDF]
, 2011 Recent biotechnological advances have permitted the manipulation of genetic sequences to treat several diseases in a process called gene therapy. However, the advance of gene therapy has opened the door to the possibility of using genetic manipulation ...
Collares, T. F. +4 more
core +5 more sources
Blood, 1971 Abstract Rabbits were rendered anemic by phlebotomy, by parenteral administration of phenylhydrazine and by phlebotomy coupled with transfusion of nonviable erythrocytes. Measurements were made of the number and iron uptake of immature erythroid cells, and the size and hemoglobin content of the circulating erythrocytes.
P, Jacobs, C A, Finch
openaire +2 more sources
Rare congenital Dyserythropoietic anemia of childhood: A case report
Clinical Case Reports, 2023 Congenital dyserythropoietic anemias (CDA) is a heterogeneous class of anemia of varying degrees of ineffective erythropoiesis and secondary hemochromatosis.
Hamzeh F. Al Hussien +4 more
doaj +1 more source
Blood, 2017 In this issue of Blood, Alvarez-Dominguez et al reveal the strategies used to achieve precise but highly dynamic translational control of protein synthesis during red blood cell development.
openaire +3 more sources
Regulation of GATA1 levels in erythropoiesis
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2019 GATA1 is considered as the “master” transcription factor in erythropoiesis. It regulates at the transcriptional level all aspects of erythroid maturation and function, as revealed by gene knockout studies in mice and by genome‐wide occupancies in ...
L. Gutiérrez +4 more
semanticscholar +1 more source
Frontiers in Physiology, 2022 Erythrocytes represent at least 60% of all cells in the human body. During circulation, they experience a huge variety of physical and chemical stimulations, such as pressure, shear stress, hormones or osmolarity changes.
Marieke von Lindern +6 more
doaj +1 more source
Only complete rejoining of DNA strand breaks after UVC allows K562 cell proliferation and DMSO induction of erythropoiesis [PDF]
, 2008 DNA strand breaks are early intermediates of the repair of UVC-induced DNA damage, however, since they severely impair cellular activities, their presence should be limited in time.
AVALLONE, BICE, FORESTI, MAGDA
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bioRxiv, 2019 Dynamic cellular processes such as differentiation are driven by changes in the abundances of transcription factors (TFs). Yet, despite years of studies we still do not know the protein copy number of TFs in the nucleus. Here, by determining the absolute
Mark A. Gillespie +11 more
semanticscholar +1 more source
Methods to assess iron and iodine status [PDF]
, 2008 Four methods are recommended for assessment of iodine nutrition: urinary iodine concentration, the goitre rate, and blood concentrations of thyroid stimulating hormone and thyroglobulin.
Zimmermann, M.B.
core +2 more sources