Results 71 to 80 of about 121,038 (379)
The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages
Frontiers in Immunology, 2022 Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the machinery through which these dead cells are recognized and phagocytically cleared is incompletely understood.
Lidia Jiménez-García +6 more
doaj +1 more source
Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression
Advanced Science, EarlyView.Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li +4 more
wiley +1 more source
Frontiers in Physiology, 2020 Erythropoietin (EPO) boosts exercise performance through increase in oxygen transport capacity following regular administration of EPO but preclinical study results suggest that single high dose of EPO also may improve exercise capacity.
Thomas Haider +12 more
doaj +1 more source
Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]
, 1990 In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias +2 more
core
Haematologica, 2020 Mammalian erythropoiesis occurs in three stages; the primitive, the fetal definitive and the adult definitive stages.[1][1] After the primitive stage, which takes place in the yolk sac, definitive erythropoiesis moves to the fetal liver and the spleen ...
S. Elahi, Siavash Mashhouri
semanticscholar +1 more source
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
Effect of Neopterin on Splenic Erythropoiesis in Mice
Pteridines, 2010 Neopterin is produced by monocytes and is a biomarker for inflammation. We recently found that neopterin induces stromal cells to produce cytokines that suppress erythropoiesis in the bone marrow of mice.
Tsuboi Isao +3 more
doaj +1 more source
bioRxiv, 2020 Human erythropoiesis is exquisitely controlled at multiple levels and its dysregulation leads to numerous human diseases. Despite many functional studies focused on classical regulators, we lack a global, system-wide understanding of post-translational ...
Özge Karayel +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi +10 more
wiley +1 more source
Fine‐Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation
Advanced Science, 2022 Lipid metabolism is essential for stemness maintenance, self‐renewal, and differentiation of stem cells, however, the regulatory function of cholesterol metabolism in erythroid differentiation is poorly studied.
Zhiyuan Lu +11 more
doaj +1 more source