Results 81 to 90 of about 121,038 (379)

Canagliflozin Improves Erythropoiesis in Diabetes Patients with Anemia of Chronic Kidney Disease

Diabetes Technology & Therapeutics, 2019
Background: We evaluated the erythropoietic effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, in type 2 diabetes patients with anemia of chronic kidney disease.
T. Maruyama, H. Takashima, H. Oguma, Yoshihiro Nakamura, M. Ohno, Kei Utsunomiya, T. Furukawa, Ritsukou Tei, M. Abe   +8 more
semanticscholar   +1 more source

Dynamic changes in murine erythropoiesis from birth to adulthood: implications for the study of murine models of anemia.

Blood Advances, 2020
Liver, spleen, and bone marrow are 3 key erythropoietic tissues in mammals. In the mouse, the liver is the predominant site of erythropoiesis during fetal development, the spleen responds to stress erythropoiesis, and the bone marrow is involved in ...
Lixiang Chen, Jie Wang, Jing Liu, Hua Wang, C. Hillyer, L. Blanc, X. An, N. Mohandas   +7 more
semanticscholar   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Cish knockout mice exhibit similar outcomes to malaria infection despite altered hematopoietic responses

Frontiers in Microbiology, 2023
The Cytokine-inducible Src homology 2 domain-containing (CISH) protein is a negative feedback regulator induced by cytokines that play key roles in immunity and erythropoiesis.
Asha L. Lakkavaram, Saeed Maymand, Wasan Naser, Wasan Naser, Alister C. Ward, Alister C. Ward, Tania F. de Koning-Ward, Tania F. de Koning-Ward   +7 more
doaj   +1 more source

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF‐1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression

Advanced Science, EarlyView.
Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun, Jieun Seo, Jiwon Koh, Seock‐Ah Im, Ki Yong Hong, Yeseon Son, Do‐Won Jeong, Junji Fukuda, Jong‐Wan Park, Yang‐Sook Chun   +9 more
wiley   +1 more source

"Splenism" - the function of spleen, as the organ conducting the interrelation of the circulatory system and hematopoiesis

Patologìâ, 2013
On Wistar rats splenic involvement into the regulation of erythropoiesis was studied. Splenomegaly was reproduced for this both by ligation of splenic veins and transfusion of suspension of washed erythrocytes that leaded to the pronounced increase in ...
V.I. Filimonov, N.V. Stepanova, I.E. Sukhomlinova, M.A. Tikhonovskaya, G.I. Bessarab, D.A. Putilin, G.V. Pirtya   +6 more
doaj   +1 more source

Comprehensive Analysis of microRNAs in Human Adult Erythropoiesis

Cells, 2021
MicroRNAs (miRNAs) are small non-coding RNAs, which play an important role in various cellular and developmental processes. The study of miRNAs in erythropoiesis is crucial to uncover the cellular pathways that are modulated during the different stages ...
Aneesha Nath, Janakiram Rayabaram, Smitha Ijee, Abhirup Bagchi, Anurag Dutta Chaudhury, Debanjan Roy, Karthik Chambayil, Jyoti Singh, Yukio Nakamura, Shaji R. Velayudhan   +9 more
doaj   +1 more source

Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia.

Journal of Clinical Investigation, 2019
β-thalassemia is a genetic anemia caused by partial or complete loss of β-globin synthesis leading to ineffective erythropoiesis and RBCs with short life-span.
V. Manolova, N. Nyffenegger, A. Flace, P. Altermatt, A. Varol, C. Doucerain, Hanna Sundstrom, F. Dürrenberger   +7 more
semanticscholar   +1 more source

DNA Methylation Episignature as a Novel Diagnostic Tool for Diamond‐Blackfan Anemia Syndrome

American Journal of Hematology, EarlyView.
Diamond‐Blackfan Anemia Syndrome (DBAS) is a congenital bone marrow failure disorder characterized by defective erythropoiesis and a spectrum of congenital anomalies, including craniofacial malformations, limb abnormalities, and cardiac and renal defects.
Paola Quarello, Karim Karimi, Slavica Trajkova, Emanuela Garelli, Mehdi Samadieh, Emanuela Iovino, Tommaso Pippucci, Giovanni Papagni, Sandra Dalfonso, Lucia Corrado, Serena Rizzo, Adriana Carando, Jennifer Kerkhof, Jessica Rzasa, Haley McConkey, Michael Levy, Marco Zecca, Francesca Fioredda, Angelica Barone, Simone Cesaro, Maria Gabelli, Francesca Torchio, Giulia Zucchetti, Maria Elena Cantarini, Paola Corti, Ugo Ramenghi, Franco Locatelli, Franca Fagioli, Bekim Sadikovic, Alfredo Brusco   +29 more
wiley   +1 more source

Impact of hospitalized vaso-occlusive crises in the previous calendar year on mortality and complications in adults with sickle cell disease: a French population-based studyResearch in context

The Lancet Regional Health. Europe
Summary: Background: Historically, sickle cell disease (SCD) patients experiencing frequent hospitalized vaso-occlusive crises (HVOC) have been associated with increased mortality, yet recent data reflecting the widespread use of hydroxyurea and ...
Jean-Benoît Arlet, Eléonore Herquelot, Ludovic Lamarsalle, Fanny Raguideau, Pablo Bartolucci   +4 more
doaj   +1 more source