Results 161 to 170 of about 187,553 (368)

Efficacy of Momelotinib in Myelofibrosis Patients: Results From a Multicenter Study

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Momelotinib, a novel JAK1/2 inhibitor with inhibitory activities on activin A receptor type I, has shown breakthrough clinical efficacy in patients with myelofibrosis (MF) and anemia, a disease‐related manifestation of challenging management. In this retrospective real‐life multicenter Italian study, we investigated the safety and efficacy of ...
Maria Carmen Martorelli   +34 more
wiley   +1 more source

Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2000
M. Brines   +7 more
semanticscholar   +1 more source

Clonal Progression and Leukemic Transformation of a TP53 Mutated Post‐Polycythaemia Vera Myelofibrosis

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Previous studies investigating the role of TP53 mutations in chronic phase MPN have yielded inconsistent results. As such, the clinical relevance of these mutations remains to be elucidated. We report a case of a 67‐year‐old woman with a leukemic transformation of a post‐polycythaemia vera myelofibrosis (post‐PV MF) that culminated in the rare
Isidor Minović   +8 more
wiley   +1 more source

Symmetric signaling by an asymmetric 1 erythropoietin : 2 erythropoietin receptor complex [PDF]

open access: yes, 2008
Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.Includes bibliographical references (p. 43-46).One erythropoietin molecule binds asymmetrically to two identical receptor monomers via erythropoietin site 1 ...
Zhang, Yingxin
core  

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

open access: yesThe FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou   +4 more
wiley   +1 more source

Living on High Altitudes Associated with Reduced Requirements of Exogenous Erythropoietin in Patients on Chronic Hemodialysis

open access: yesRevista Colombiana de Nefrología
Introduction: During the last decades the use of erythropoiesis stimulating agents has significantly diminished the prevalence of anemia in patients receiving chronic hemodialysis.
André Benítez   +10 more
doaj   +1 more source

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