Results 31 to 40 of about 78,398 (259)

Erythropoietin level in normal and abnormal human seminal fluid

Андрология и генитальная хирургия, 2021
Background. There are not enough publications devoted to the study of erythropoietin in human sperm. According to the results of these studies, the erythropoietin takes part in the regulation of spermatogenesis, affecting the synthesis of hormones, in ...
D. Yu. Sosnin, K. R. Galkovich, A. V. Krivtsov1   +2 more
doaj   +1 more source

Effect of Red Blood Cell Transfusion on Inflammatory and Angiogenic Pathways in Patients With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt, Sanjay R. Thakoerdin, Maud Zwolsman, Gaby Stegemann, Hanke Matlung, Taco W. Kuijpers, Bart J. Biemond, Karin Fijnvandraat, Robin van Bruggen, Erfan Nur   +9 more
wiley   +1 more source

Studying of the standardization principles of pharmacological activity of recombinant erythropoietin preparations

Стандартные образцы, 2017
Analysis of the publications devoted to the structure, functions, mechanism of action of erythropoietin is given in the article. Erythropoietin preparations derived from recombinant DNA technology are a mixture of isoforms with different biological ...
A. K. Yakovlev, L. A. Gayderova, N. A. Alpatova, T. N. Lobanova, E. L. Postnova, E. I. Yurchikova, T. A. Batuashvili, R. A. Volkova, V. N. Podkuiko, Yu. V. Olefir   +9 more
doaj   +1 more source

Influence of hemoglobin level and dose of administered recombinant human beta erythropoietin on survival of hemodialysis patients [PDF]

Vojnosanitetski Pregled, 2011
Background/Aim. In patients with end-stage renal disease, treatment with erythropoietin lowers cardiovascular morbidity, improves quality of life and patient survival.
Knežević Violeta, Milošević Aleksandra, Vodopivec Slavenka, Božić Dušan, Budošan Ivana, Majić Milena   +5 more
doaj   +1 more source

Autosomal Dominant Erythrocytosis Caused by Non‐Renal Erythropoietin (EPO) Due to EPO c.‐136 G>A Germline Mutation

American Journal of Hematology, EarlyView.
A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova, Dusan Hrckulak, Veronika Zimolova, Felipe R. Lorenzo, Jihyun Song, Katerina Vecerkova, Olga Babosova, Linda Berkova, Vladimir Korinek, Steve Elliott, Josef T. Prchal   +10 more
wiley   +1 more source

Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. [PDF]

PLoS ONE, 2007
The induction of tumor angiogenesis, a pathologic process critical for tumor progression, is mediated by multiple regulatory factors released by tumor and host cells.
Matthew E Hardee, Yiting Cao, Ping Fu, Xiaohong Jiang, Yulin Zhao, Zahid N Rabbani, Zeljko Vujaskovic, Mark W Dewhirst, Murat O Arcasoy   +8 more
doaj   +1 more source

Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury [PDF]

, 2022
Lauren L. Jantzie, Sankar Muthukumar, Yuma Kitase, Vikram Vasan, Mohammed Fouda, Sarah Hamimi, Christopher Burkhardt, Vera Joanna Burton, Gwendolyn Gerner, Joseph Scafidi, Xiaobu Ye, Frances J. Northington, Shenandoah Robinson   +12 more
openalex   +1 more source

The Prevalence and Implications of Polypharmacy in Individuals With Type 1 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Polypharmacy is increasingly recognized as a relevant issue in diabetes care, but its prevalence and clinical relevance in individuals with type 1 diabetes remain underexplored. This study aimed to determine the prevalence of polypharmacy and to identify associated clinical and psychological factors. Participants were recruited from a tertiary diabetes
Namam Ali, Stephan van Erp, Cornelis Kramers, Cornelis J. Tack, Bastiaan E. de Galan   +4 more
wiley   +1 more source

Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo. [PDF]

Protein Sci
Abstract Recent studies have shown that tetravalent antibodies are potent and efficacious agonists of the erythropoietin (EPO) receptor (EPOR) both in vitro and in vivo. To identify antibody‐based erythropoiesis‐stimulating agents (ESAs) with therapeutic potential, we evaluated various tetravalent antibody formats for EPOR agonism and key biophysical ...
Adams JJ, Blazer LL, Chung J, Karimi M, Davidson T, Blair B, Waddle C, Hokanson CA, Bruce HA, Singer AU, Tombak EM, Gildemann K, Tamberg N, Kiiver K, Ustav M, Ma Y, Colombo L, Huang LJ, Michnick SW, Moe OW, Sidhu SS.   +20 more
europepmc   +2 more sources

Improvement of EPO Transgene Detection From Polymeric Dried Blood Spots for Antidoping Application

Drug Testing and Analysis, EarlyView.
This article presents an optimized protocol for gene doping detection. Starting from one spot DBS (20 μL), concentrated DNA was obtained and real‐time PCR parameters were adjusted for increased detection. Robust detection of 5000 copies/mL of transgene was validated for polymeric device TASSO M‐20.
Alexandre Marchand, Ingrid Roulland, Magnus Ericsson   +2 more
wiley   +1 more source