Results 191 to 200 of about 14,736 (216)
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ESCRT-III recognition by VPS4 ATPases
Nature, 2007The ESCRT (endosomal sorting complex required for transport) pathway is required for terminal membrane fission events in several important biological processes, including endosomal intraluminal vesicle formation, HIV budding and cytokinesis. VPS4 ATPases perform a key function in this pathway by recognizing membrane-associated ESCRT-III assemblies and ...
Wesley I Sundquist +2 more
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Functional Reconstitution of ESCRT-III Assembly and Disassembly [PDF]
Cell, 2009 Receptor downregulation in the MVB pathway is mediated by the ESCRT complexes. ESCRT-III is composed of four protein subunits that are monomeric in the cytosol and oligomerize into a protein lattice only upon membrane binding. Recent studies have shown that the ESCRT-III protein Snf7 can form a filament by undergoing homo-oligomerization.
David Teis +2 more
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Comprehensive analysis of yeast ESCRT-III composition in single ESCRT-III deletion mutants
Biochemical Journal, 2019Abstract The endosomal sorting complex required for transport (ESCRT)-III is associated with a multitude of cellular processes involving membrane remodeling and abscission. The exact composition of ESCRT-III and the contribution of individual ESCRT-III family members to these diverse functions is unclear.
Christian Heinzle +3 more
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Revolving around constriction by ESCRT-III
Nature Cell Biology, 2017The endosomal sorting complex required for transport (ESCRT)-III is critical for membrane abscission; however, the mechanism underlying ESCRT-III-mediated membrane constriction remains elusive. A study of the dynamic assembly and disassembly of the ESCRT-III machinery in vitro and in vivo now suggests that the turnover of the observed spiralling ...
Franquelim, H., Schwille, P.
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Structure and function of ESCRT-III
Biochemical Society Transactions, 2009ESCRT-III (endosomal sorting complex required for transport III) is required for the formation and abscission of intraluminal endosomal vesicles, which gives rise to multivesicular bodies, budding of some enveloped viruses and cytokinesis. ESCRT-III is composed of 11 members in humans, which, except for one, correspond to the six ESCRT-III-like ...
Lata, S +5 more
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ESCRT-III polymers in membrane neck constriction
Trends in Cell Biology, 2012The endosomal sorting complex required for transport (ESCRT)-III machinery contributes to membrane deformation and scission in cytokinesis, intraluminal vesicle formation, autophagy and virus budding. Recombinant ESCRT-III subunits polymerize in vitro into filaments, tubes, sheets or rings, and ESCRT-III-dependent filaments have been observed in cells ...
Guizetti, Julien, Gerlich, Daniel W.
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Fine-tuning pyroptosis with ESCRT-III
Science, 2018Immunology Pyroptosis is an inflammatory form of cell death induced by select caspases downstream of inflammasome complexes. These caspases cleave gasdermin D (GSDMD), whose N-terminal fragments quickly form large permeability pores that induce cell death. However, a large percentage of cells with active inflammasomes are resistant to pyroptosis.
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PspA adopts an ESCRT-III-like fold and remodels bacterial membranes
Cell, 2021Benedikt Junglas +2 more
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Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily
Cell, 2021Matteo Tassinari +2 more
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An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission
Cell, 2020Anna-Katharina Pfitzner +2 more
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