Results 31 to 40 of about 33,348 (245)
PLoS Pathogens, 2022 As the important molecular machinery for membrane protein sorting in eukaryotic cells, the endosomal sorting and transport complexes (ESCRT-0/I/II/III and VPS4) usually participate in various replication stages of enveloped viruses, such as endocytosis ...
Chun-Chun Liu +12 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 The endosomal sorting complex required for transport (ESCRT) is formed by ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III complexes, and accessory proteins. It conducts vesicular trafficking in eukaryotes through the formation of vesicles and membrane fission and ...
Ausencio Galindo +8 more
doaj +1 more source
WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]
, 2015 Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T +6 more
core +1 more source
Accessory ESCRT‐III proteins are conserved and selective regulators of Rab11a‐exosome formation
Journal of Extracellular Vesicles, 2023 Exosomes are secreted nanovesicles with potent signalling activity that are initially formed as intraluminal vesicles (ILVs) in late Rab7‐positive multivesicular endosomes, and also in recycling Rab11a‐positive endosomes, particularly under some forms of
Pauline P Marie +10 more
semanticscholar +1 more source
ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis [PDF]
Open Biology, 2016 Endocytosis and local protein synthesis (LPS) act coordinately to mediate the chemotropic responses of axons, but the link between these two processes is poorly understood.
Filip A. Konopacki +5 more
doaj +1 more source
Nature Communications, 2023 Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a high-throughput, proteome-wide peptide screen to identify protein-protein interaction inhibitors that ...
Satra Nim +17 more
semanticscholar +1 more source
AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.
PLoS Genetics, 2021 To complete mitosis, the bridge that links the two daughter cells needs to be cleaved. This step is carried out by the endosomal sorting complex required for transport (ESCRT) machinery. AKTIP, a protein discovered to be associated with telomeres and the
Chiara Merigliano +19 more
doaj +1 more source
The plant unique ESCRT component FREE1 regulates autophagosome closure
Nature Communications, 2023 The energy sensor AMP-activated protein kinase (AMPK) can activate autophagy when cellular energy production becomes compromised. However, the degree to which nutrient sensing impinges on the autophagosome closure remains unknown.
Yonglun Zeng +17 more
semanticscholar +1 more source
Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome [PDF]
, 2016 In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles.
Gould, Gwyn W.
core +2 more sources
ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis
eLife, 2016 The endosomal sorting complexes required for transport (ESCRT) pathway facilitates multiple fundamental membrane remodeling events. Previously, we determined X-ray crystal structures of ESCRT-III subunit Snf7, the yeast CHMP4 ortholog, in its active and ...
Shaogeng Tang +5 more
doaj +1 more source