Results 61 to 70 of about 33,348 (245)

Vps60 initiates alternative ESCRT-III filaments

Journal of Cell Biology, 2023
Pfitzner, Zivkovic, et al. characterize a novel membrane-bound ESCRT-III copolymer initiated by Vps60. They show that Vps60-based copolymers are in vitro spatially and biochemically distinct from classical Snf7-based ESCRT-III filaments.
Anna-Katharina Pfitzner, Henry Zivkovic, César Bernat-Silvestre, Matthew West, Tanner Peltier, Frédéric Humbert, G. Odorizzi, Aurélien Roux   +7 more
semanticscholar   +1 more source

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I. [PDF]

, 2015
The Kaposi's sarcoma-associated herpes virus (KSHV) K3 viral gene product effectively down-regulates cell surface MHC class I. K3 is an E3 ubiquitin ligase that promotes Lys(63)-linked polyubiquitination of MHC class I, providing the signal for clathrin ...
Boname, Jessica M, Bowers, Katherine, Bright, Nicholas A, Evans, Jennifer L, Lehner, Paul J, Luzio, J Paul, Parkinson, Michael DJ, Piper, Siân C   +7 more
core   +2 more sources

SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. [PDF]

, 2010
Hereditary spastic paraplegias (HSPs, SPG1-46) are inherited neurological disorders characterized by lower extremity spastic weakness. Loss-of-function SPG20 gene mutations cause an autosomal recessive HSP known as Troyer syndrome.
Bakowska, Joanna C, Blackstone, Craig, Hurley, James H, Parker, Rell L, Renvoisé, Benoît, Yang, Dong   +5 more
core   +3 more sources

Syntaxin 16 is a master recruitment factor for cytokinesis [PDF]

, 2013
Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and ...
Alexandra Kaupisch, Barr FA, Bastos RN, Bissig C, Blum R, Carlton J, Carlton JG, Carr CM, Chen X.-W., Chesneau L, Choudhury A, Dambournet D, Dulubova I, Elia N, Fededa JP, Fielding AB, Fielding AB, Francis A. Barr, Glotzer M, Goss JW, Gromley A, Guizetti J, Gwyn W. Gould, Hong W, Hélia Neto, Jung JJ, Lee HH, Louise L. Collins, Low SH, Manickam V, Mondal G, Munson M, Neto H, Prekeris R, Proctor KM, Rannou Y, Riggs KA, Scales SJ, Schiel JA, Schiel JA, Schiel JA, Schiel JA, Simon GC, Simonsen A, Struthers MS, Tellam JT, TerBush DR, Xu H, Zhang XM   +48 more
core   +2 more sources

Coordination between ESCRT function and Rab conversion during endosome maturation

EMBO Journal
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5 positive early endosomes receive proteins from the plasma membrane.
Daniel P. Ott, Samit Desai, J. Solinger, Andres Kaech, A. Spang   +4 more
semanticscholar   +1 more source

Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly

eLife, 2018
The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis.
Daniel S Johnson, Marina Bleck, Sanford M Simon   +2 more
doaj   +1 more source

The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. [PDF]

, 2015
The sorting of G protein-coupled receptors (GPCRs) to lysosomes is critical for proper signaling and cellular responses. We previously showed that the adaptor protein ALIX regulates lysosomal degradation of protease-activated receptor-1 (PAR1), a GPCR ...
Dores, Michael R, J Grimsey, Neil, Lin, Huilan, Mendez, Francisco, Trejo, JoAnn   +4 more
core   +1 more source

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions

Nature Communications, 2021
Upon starvation, cells rewire their metabolism, switching from glucose-based metabolism to mitochondrial oxidation of fatty acids, which require the transfer of FAs from lipid droplets (LDs) to mitochondria at mitochondria−LD membrane contact sites (MCSs)
Jingru Wang, Na Fang, Juan Xiong, Yuanjiao Du, Yue Cao, Wei-Ke Ji   +5 more
semanticscholar   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

Scientific Reports, 2017
HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (ESCRTs ...
Deepankar Gahloth, Graham Heaven, Thomas A. Jowitt, A. Paul Mould, Jordi Bella, Clair Baldock, Philip Woodman, Lydia Tabernero   +7 more
doaj   +1 more source