Results 71 to 80 of about 28,813 (238)

Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection [PDF]

, 2011
Copyright © 2012, American Society for Microbiology. All Rights ReservedThe influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral strains.
B. Nal, Barman, Barman, Bruce, Carlton, Chen, Chen, Chen, Cheung, Ciampor, Compans, Creutz, Cubells, Eierhoff, Enrich, F. Kien, Formstecher, Fromont-Racine, Gannagé, Gerke, Goswami, Grantham, Guan, Gujuluva, H. Ma, Harris, Hartshorn, Henkel, Hoffmann, Holsinger, Honda, Hui, Ichinohe, Iwatsuki-Horimoto, K. S. Tse, L. L. M. Poon, Lakadamyali, Lamb, Lamb, Lee, Li, Liu, M. Maniere, McCown, McCown, Monastyrskaya, N. Lagarde, Nayak, Nefkens, Noton, Palese, Pinto, Pinto, Pinto, Pleschka, Rossman, Rossman, Rossman, Scheiffele, Simpson-Holley, Smythe, Sun, Thaa, Thomas, Ueda, Vila de Muga, Wang, Wang, Welsch, Y. Zhang   +69 more
core   +2 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

ESCRT proteins [PDF]

BioArchitecture, 2011
ESCRT pathway proteins play a key role in sorting ubiquitinated membrane receptors towards lysosomes providing an important mechanism for attenuating cell surface receptor signaling. However, recent studies point to a positive role of ESCRT proteins in signal transduction in multiple species studied under physiological and pathological conditions ...
Chun, Tu, Gulzar, Ahmad, Bhopal, Mohapatra, Sohinee, Bhattacharyya, Cesar F, Ortega-Cava, Byung Min, Chung, Kay-Uwe, Wagner, Srikumar M, Raja, Mayumi, Naramura, Vimla, Band, Hamid, Band   +10 more
openaire   +2 more sources

A novel minimal in vitro system for analyzing HIV-1 Gag mediated budding

, 2014
A biomimetic minimalist model membrane was used to study the mechanism and kinetics of cell-free in vitro HIV-1 Gag budding from a giant unilamellar vesicle (GUV).
Gill, Sarjeet, Gui, Dong, Gupta, Sharad, Huang, I-Chueh, Mohideen, Umar, Rao, A. L. N., Xu, Jun, Zandi, Roya   +7 more
core   +1 more source

Genomic Inference of the Metabolism and Evolution of the Archaeal Phylum Aigarchaeota [PDF]

, 2018
Microbes of the phylum Aigarchaeota are widely distributed in geothermal environments, but their physiological and ecological roles are poorly understood.
Castelle, Cindy J., Hedlund, Brian P., Hua, Zheng-Shuang, Knight, Rob, Li, Wen-Jun, Li, Yu-Xian, Liu, Lan, Qi, Yan-Ling, Qu, Yan-Ni, Rao, Yang-Zhi, Shu, Wen-Sheng, Tian, Ye, Yin, Yi-Rui, Zhou, En-Min, Zhu, Qiyun   +14 more
core   +3 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

No ESCRTs for Exosomes

Science, 2008
Two pathways within endosomes use specific protein complexes or membrane domains to direct cargo for degradation or secretion from cells.
Marsh, M., van Meer, G.
openaire   +3 more sources

Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata

BMC Biology, 2021
Background Comparing a parasitic lineage to its free-living relatives is a powerful way to understand how that evolutionary transition to parasitism occurred.
Shweta V. Pipaliya, Rui Santos, Dayana Salas-Leiva, Erina A. Balmer, Corina D. Wirdnam, Andrew J. Roger, Adrian B. Hehl, Carmen Faso, Joel B. Dacks   +8 more
doaj   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes

Membranes, 2022
The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III,
Yolanda Olmos
doaj   +1 more source