Results 91 to 100 of about 19,636 (235)
Reclaiming Anatomy as Method: From Morphological Reasoning to Clinical Relevance
Clinical Anatomy, EarlyView.ABSTRACT In recent decades, molecular biology and omics technologies have profoundly reshaped biomedical research, with genomics, proteomics, and other high‐throughput approaches dominating scientific agendas and funding priorities. Within this molecular paradigm, however, the anatomical sciences face an epistemic and institutional tension: morphology,
Katia Cortese, Marco Frascio
wiley +1 more source
How Ubiquitin Functions with ESCRTs [PDF]
Traffic, 2011 The endosomal‐sorting complex required for transport (ESCRT) apparatus has multiple ubiquitin (Ub)‐binding domains and participates in a wide variety of cellular processes. Many of these ESCRT‐dependent processes are keenly regulated by Ub, which serves as a lysosomal‐sorting signal for membrane proteins targeted into multivesicular bodies (MVBs) and ...
S Brookhart, Shields, Robert C, Piper
openaire +2 more sources
ESCRT-III on endosomes:New functions, new activation pathway [PDF]
, 2016 The multivesicular body (MVB) pathway sorts ubiquitinated membrane cargo to intraluminal vesicles (ILVs) within the endosome, en route to the lysosomal lumen.
Woodman, Philip; id_orcid
core +1 more source
Divergent pathways lead to ESCRT-III-catalyzed membrane fission [PDF]
, 2010 Endosomal sorting complexes required for transport (ESCRT) have been implicated in topologically similar but diverse cellular and pathological processes including multivesicular body (MVB) biogenesis, cytokinesis and enveloped virus budding.
Macheboeuf, P +11 more
core +1 more source
A unique role for the host ESCRT proteins in replication of Tomato bushy stunt virus. [PDF]
PLoS Pathogens, 2009 Plus-stranded RNA viruses replicate in infected cells by assembling viral replicase complexes consisting of viral- and host-coded proteins. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host revealed the ...
Daniel Barajas, Yi Jiang, Peter D Nagy
doaj +1 more source
Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation
iNew Medicine, EarlyView.The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng +3 more
wiley +1 more source
Constitutively active ESCRT-II suppresses the MVB-sorting phenotype of ESCRT-0 and ESCRT-I mutants
Molecular Biology of the Cell, 2015 The endosomal sorting complex required for transport (ESCRT) protein complexes function at the endosome in the formation of intraluminal vesicles (ILVs) containing cargo proteins destined for the vacuolar/lysosomal lumen. The early ESCRTs (ESCRT-0 and -I) are likely involved in cargo sorting, whereas ESCRT-III and Vps4 function to sever the neck of the
Mageswaran, Shrawan Kumar +3 more
openaire +2 more sources
Differential physiological roles of ESCRT complexes in Caenorhabditis elegans [PDF]
, 2011 Endosomal sorting complex required for transport (ESCRT) complexes are involved in endosomal trafficking to the lysosome, cytokinesis, and viral budding.
Joohong Ahnn +13 more
core +1 more source
Nature Communications, 2018 Plant development, defense, and many physiological processes rely on the endosomal sorting complex required for transport (ESCRT) machinery to control the homeostasis of membrane proteins by selective vacuolar degradation.
Jinbo Shen +6 more
doaj +1 more source
Identification of Novel Interacting Proteins of FUZ and GPR161
PROTEOMICS, EarlyView.ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar +3 more
wiley +1 more source