Results 111 to 120 of about 28,813 (238)

Super-resolution imaging of ESCRT-proteins at HIV-1 assembly sites.

PLoS Pathogens, 2015
The cellular endosomal sorting complex required for transport (ESCRT) machinery is involved in membrane budding processes, such as multivesicular biogenesis and cytokinesis.
Jens Prescher, Viola Baumgärtel, Sergey Ivanchenko, Adriano A Torrano, Christoph Bräuchle, Barbara Müller, Don C Lamb   +6 more
doaj   +1 more source

CHARACTERIZATION OF THE UBIQUITIN LIGASE, UBE4B, IN ENDOCYTIC TRAFFICKING [PDF]

, 2017
Endocytosis is a process by which cells internalize membrane proteins to remove them from the plasma membrane, allowing cells to regulate the cell surface expression of transmembrane proteins.
Sirisaengtaksin, Natalie, Sirisaengtaksin, Natalie   +1 more
core   +1 more source

AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway [PDF]

, 2012
The sorting of signaling receptors within the endocytic system is important for appropriate cellular responses. After activation, receptors are trafficked to early endosomes and either recycled or sorted to lysosomes and degraded.
Dores, Michael R, Lin, Huilan, Marchese, Adriano, Montagne, William A, Paing, May M, Trejo, JoAnn   +5 more
core   +2 more sources

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.

PLoS ONE, 2014
Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated ...
Emiliana Tognon, Nadine Wollscheid, Katia Cortese, Carlo Tacchetti, Thomas Vaccari   +4 more
doaj   +1 more source

Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments. [PDF]

, 2015
Compartmentalisation of cellular processes is fundamental to regulation of metabolism in Eukaryotic organisms and is primarily provided by membrane-bound organelles.
Achalkumar, Adell, Agromayor, Aimon, Alexa J. Cleasby, Angelova, Angelova, Apellaniz, Arriaga, Axelrod, Ayton, Bacia, Bagatolli, Barbara Ciani, Baumgart, Baumgart, Baumgart, Bayburt, Bayley, Beales, Beales, Beales, Benkoski, Bennett, Bergstrom, Bernchou, Bernchou, Betz, Bleicken, Boden, Boura, Boyle, Burns, Campillo, Carvalho, Cashikar, Castellana, Chan, Chen, Cho, Cho, Cho, Churchman, Ciani, Connell, Cremer, Cui, Dahlin, Das, Denisov, Diao, Durrieu, Eggeling, Elani, Elani, Epand, Fabrikant, Fletcher, Frolov, Fuertes, Girard, Goh, Goksu, Gordon, Gradišar, Harrison, Haswell, Haustein, Helfrich, Henriksen, Hiyama, Holthuis, Honigmann, Hurley, Härtel, Iwabuchi, Jena, Jeuken, Karamdad, Katayama, Kiessling, Korlach, Kozlov, Kozlov, Kraft, Lamblet, Langecker, Lata, Leduc, Lin, Lindau, Liu, Longo, Ly, Lyman, López-Montero, Maglia, Majd, Manley, Marsh, Marsh, Marsh, Marsh, Mart, Martens, Melikyan, Mercker, Monck, Montes, Moran-Mirabal, Nath, Nath, Neumann, Nourian, Olbrich, Osawa, Parasassi, Park, Parlati, Paul A. Beales, Pautot, Pautot, Pecreaux, Persson, Peterman, Przybylo, Rabe, Ramadurai, Ramakrishnan, Raschle, Rawicz, Richmond, Ritchie, Robson Marsden, Roux, Ruan, Rydell, Różycki, Saarikangas, Schoen, Schwille, Semrau, Serien, Shaklee, Shi, Shoemaker, Shum, Siegel, Simonsson, Simunovic, Sorre, Sorre, Sorre, Soumpasis, Stachowiak, Stachowiak, Stegmann, Studer, Suetsugu, Syeda, Szoka, Söllner, Takatsuki, Tanaka, Tanaka, Templer, Thomas, Thompson, Tian, Tonnesen, Troutier, Tsai, Tsurudome, Voeltz, Vogel, Wagner, Wang, Wang, Weber, Weidemann, Weinberger, Wetterau, Wieprecht, Wilson, Wollert, Wollert, Woodman, Woolfson, Worsfold, Xu, Yoon, Yu, Yu, Yuan, Zhang, Zhao, Zhu, Zick, Árnadóttir   +198 more
core   +2 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

ESCRTs [PDF]

Current Biology, 2007
Malerød, Lene, Stenmark, Harald
openaire   +2 more sources

The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes

The EMBO Journal
The ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgard archaea, currently considered the closest prokaryotic relative of ...
Nataly Melnikov, Benedikt Junglas, Gal Halbi, Dikla Nachmias, Erez Zerbib, Noam Gueta, Alexander Upcher, Ran Zalk, Carsten Sachse, Anne Bernheim-Groswasser, Natalie Elia   +10 more
doaj   +1 more source