Results 111 to 120 of about 19,636 (235)
ESCRT and autophagies: Endosomal functions and beyond [PDF]
, 2018 International audienceESCRT (endosomal sorting complex required for transport) machinery has been initially identified for its role during endocytosis, which allows membrane proteins and lipids to be degraded in the lysosome.
Christophe Lefebvre +5 more
core +1 more source
ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.
PLoS ONE, 2014 Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated ...
Emiliana Tognon +4 more
doaj +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Structural and functional organisation of ESCRT complexes [PDF]
, 2007 My structure of the highly conserved heterotrimeric ESCRT-I core provides a blueprint for the assembly of ESCRT-I. The structure shows a fan-like arrangement of three helical hairpins, each corresponding to a different subunit.
Gill, D J
core
ESCRT-II, an Endosome-Associated Complex Required for Protein Sorting Crystal Structure and Interactions with ESCRT-III and Membranes [PDF]
, 2004 ESCRT-I, -II, and -III protein complexes are sequentially recruited to endosomal membranes, where they orchestrate protein sorting and MVB biogenesis. In addition, they play a critical role in retrovirus budding.
González, Beatriz +3 more
core +1 more source
eLife, 2017 The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes, together with the recruitment of at least two Vps4 hexamers.
Manuel Alonso Y Adell +15 more
doaj +1 more source
The FEBS Journal, EarlyView.TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior +5 more
wiley +1 more source
Revolving around constriction by ESCRT-III [PDF]
, 2017 The endosomal sorting complex required for transport (ESCRT)-III is critical for membrane abscission; however, the mechanism underlying ESCRT-III-mediated membrane constriction remains elusive. A study of the dynamic assembly and disassembly of the ESCRT-
Petra Schwille +3 more
core +1 more source
PLoS Pathogens, 2012 The cellular endosomal sorting complex required for transport (ESCRT) machinery participates in membrane scission and cytoplasmic budding of many RNA viruses. Here, we found that expression of dominant negative ESCRT proteins caused a blockade of Epstein-
Chung-Pei Lee +9 more
doaj +1 more source