Results 121 to 130 of about 19,636 (235)
Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
The FEBS Journal, EarlyView.EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source
Structure and function of ESCRT-III [PDF]
, 2009 ESCRT-III (endosomal sorting complex required for transport III) is required for the formation and abscission of intraluminal endosomal vesicles, which gives rise to multivesicular bodies, budding of some enveloped viruses and cytokinesis.
Lata, S +5 more
core +1 more source
Journal of Periodontal Research, EarlyView.The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag +6 more
wiley +1 more source
The green ESCRTs: Newly defined roles for ESCRT proteins in plants
Journal of Biological ChemistryEndocytosis and endosomal trafficking of plasma membrane proteins for degradation regulate cellular homeostasis and development. As part of these processes, ubiquitinated plasma membrane proteins (cargo) are recognized, clustered, and sorted into intraluminal vesicles of multivesicular endosomes by endosomal sorting complexes required for transport ...
Ethan Weiner +4 more
openaire +2 more sources
Functional Reconstitution of ESCRT-III Assembly and Disassembly [PDF]
, 2009 SummaryReceptor downregulation in the MVB pathway is mediated by the ESCRT complexes. ESCRT-III is composed of four protein subunits that are monomeric in the cytosol and oligomerize into a protein lattice only upon membrane binding.
Saksena, Suraj +4 more
core +1 more source
The role of clathrin in post‐Golgi secretion in plant cells
New Phytologist, EarlyView.Morphology of Arabidopsis thaliana XVE»amiCHC seedlings. Summary Within the plant endomembrane system, the vesicle coat protein clathrin localizes to the plasma membrane (PM) and the trans‐Golgi Network/early endosome (TGN/EE). While the role of clathrin in endocytosis at the PM is well established, its function at TGN/EE, presumably in late secretion (
Maciek Adamowski +4 more
wiley +1 more source
MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between [PDF]
Current Opinion in Cell Biology, 2011 Multivesicular bodies (MVBs) are endosomes that have internalized portions of the limiting membrane into the compartment, thereby forming intralumenal vesicles. This vesicle formation is unusual in that it is directed away from the cytoplasm, which requires a unique mechanism unlike any mechanism described for other vesicle formation events.
openaire +2 more sources
Gag VLP release can bypass ESCRT-I/ALIX for recruitment of ESCRT-III/VPS4. [PDF]
, 2016 (A) ESCRT-III/VPS4 is retained within released VLPs independently of ESCRT-I/ALIX recruitment. The ESCRT proteins, Tsg101, ALIX, CHMP4b, and VPS4A, were co-expressed as HA-tagged ORFs along with the Gag variants in 293T cells as indicated.
Saveez Saffarian (249084) +1 more
core +1 more source
The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes
The EMBO JournalThe ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgard archaea, currently considered the closest prokaryotic relative of ...
Nataly Melnikov +10 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad +6 more
wiley +1 more source