Results 131 to 140 of about 19,636 (235)
ESCRTs: the final cut for cells [PDF]
Nature Reviews Molecular Cell Biology, 2019 Arnaud Echard discusses two studies that uncovered a key role for the ESCRT machinery in cytokinesis.
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, 2015 (A) A simplified schematic of the interaction scheme between HIV-1 assembly sites and the ESCRT recruitment pathway. The constructs analyzed in this study are highlighted in purple.
Jens Prescher (695435) +6 more
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The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
The Journal of Physiology, EarlyView.Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas +5 more
wiley +1 more source
Role And Regulation Of ESCRT-III In Multivesiculr Body Biogenesis [PDF]
, 2009 Endosomal sorting complex required for transports: ESCRT) machinery responsible for multivesicular body: MVB) biogenesis is essential for receptor downregulation, viral budding and cytokinesis.
Shim, Soomin
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MedComm – Oncology, Volume 5, Issue 3, September 2026.Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
wiley +1 more source
Frontiers in ImmunologyBackgroundStudies have shown that ESCRT genes affect cell aging, immune environment, and tumors. BRCA was used to explore its effects on tumor prognosis and therapy.MethodsThe data sets of Cancer Genome Atlas (TCGA), Genome-Tissue Expression Plan (GTEX),
Xiao-rui Chen +6 more
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Autophagy in MASLD: A Metabolic and Precision Medicine Perspective
Liver International, Volume 46, Issue 9, September 2026.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga +4 more
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The Secret (Mitotic) Life of Clathrin
Traffic, Volume 27, Issue 3, September 2026.A perspective on the function of clathrin at the mitotic spindle during cell division. ABSTRACT The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of endocytosis. During
Stephen J. Royle
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Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.Mesenchymal stem cell‐derived exosomes (MSC‐sEVs) show preclinical promise for cardiac repair via anti‐inflammatory, anti‐apoptotic, pro‐angiogenic and anti‐fibrotic effects. However, translational hurdles remain, including non‐standardized isolation, unvalidated potency assays, incomplete GMP manufacturing, and lack of completed Phase II/III trials ...
Sakhavat Abolhasani +2 more
wiley +1 more source
ESCRTs Take on a Job in Surveillance [PDF]
Cell, 2014 Nuclear pore assembly can go awry, but how the cell handles defective intermediates has been an ongoing question. In this issue, Lusk and colleagues describe a surveillance pathway during nuclear pore assembly and, in doing so, identify a new role for proteins that function at the endosome and plasma membrane.
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