Results 131 to 140 of about 28,813 (238)

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Ligand‐induced ubiquitination regulates endocytosis and homeostasis of the ERECTA receptor kinase for stomatal development

New Phytologist, EarlyView.
Summary Stomatal patterning on the plant epidermis is regulated by the ERECTA family of leucine‐rich repeat receptor kinases (LRR‐RKs). While ubiquitination has emerged as a key regulatory mechanism for the endocytosis of receptor kinases, the precise molecular connections among ERECTA ubiquitination, endocytosis, and its biological functions remain ...
Liangliang Chen, Minh Huy Vu, Pengfei Bai, Alicia M. Cochran, Crystal F. Ying, Keiko U. Torii   +5 more
wiley   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

ESCRT may function as a tumor biomarker, transitioning from pan-cancer analysis to validation within breast cancer

Frontiers in Immunology
BackgroundStudies have shown that ESCRT genes affect cell aging, immune environment, and tumors. BRCA was used to explore its effects on tumor prognosis and therapy.MethodsThe data sets of Cancer Genome Atlas (TCGA), Genome-Tissue Expression Plan (GTEX),
Xiao-rui Chen, Xiao-rui Chen, Xue-ying Tan, Zong-liang Zhang, Jiang-shui Yuan, Wei-qing Song, Wei-qing Song   +6 more
doaj   +1 more source

Isolation of Extracellular Vesicles From Mouse Brown Adipose Tissue Secretome Using Size‐Exclusion Chromatography

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Schematic depicting isolation of extracellular vesicles (EVs) from brown adipose tissue (BAT) and their confirmation and quantification by proteomics analysis. The graphical abstract was created using BioRender.com. ABSTRACT Brown adipose tissue (BAT) is a thermogenic tissue that functions in an endocrine, paracrine, and autocrine manner.
Parth Pardeshi, Daniel Velasquez‐Ramirez, Juan David Salazar‐Gil, Tatiana Cuellar‐Gaviria, Lisa A. Baer, Natalia Higuita‐Castro, Kristin I. Stanford   +6 more
wiley   +1 more source

Cell Biology: ESCRTing Trouble Out! [PDF]

Current Biology, 2014
Calcium entry through a plasma membrane defect leads to the local recruitment of endosomal complex required for transport (ESCRT) proteins. These proteins are hypothesized to drive an outward bending of the affected plasma membrane, forming a small bud that is then shed from the cell, along with the troublesome defect.
openaire   +2 more sources

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Coordination of the host Vps4-Vta1 complex and the viral core protein Ac93 facilitates entry of Autographa californica multiple nucleopolyhedrovirus budded virions

Journal of Virology
The endosomal sorting complex required for transport (ESCRT) is a protein machine mediating membrane scission. In intraluminal vesicle (ILV) formation, ESCRT-0 targets cargoes and recruits ESCRT-I/-II to create membrane invagination, whereas ESCRT-III ...
Xiaorong Yue, Ning Ji, Yixiang Ma, Qianlong Yu, Lisha Bai, Zhaofei Li   +5 more
doaj   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

An ESCRT into the Endosome [PDF]

Molecular Cell, 2002
Multivesicular endosomes sort ubiquitinated membrane proteins for degradation by incorporating them into inwardly budding vesicles. The recent identification of two new oligomeric components of the sorting machinery gives us a detailed view of the complex protein-protein interactions driving this process.
openaire   +2 more sources