Results 81 to 90 of about 19,636 (235)

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

Mechanisms of ESCRT exploitation by DNA viruses. [PDF]

, 2023
(1) The DNA virus HSV-1 requires ESCRT components for (1a) primary envelopment at the nucleus via the arginine-rich cluster at the UL34 viral protein and (1b) secondary envelopment at the trans-Golgi via the P[S/T]AP and YPXL late domain motifs encoded ...
Vern B. Carruthers (8462907), Yolanda Rivera-Cuevas (11831761)   +1 more
core   +1 more source

Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation

Life Science Alliance, 2022
This study describes an activity-dependent mechanism for transporting ESCRT-0 protein Hrs to synaptic vesicle (SV) pools, facilitating SV protein degradation in response to increased neuronal firing.
Veronica Birdsall, Konner Kirwan, Mei Zhu, Yuuta Imoto, Scott M Wilson, Shigeki Watanabe, Clarissa L Waites   +6 more
doaj   +1 more source

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Evolution and assembly of ESCRTs

Biochemical Society Transactions, 2009
The AAA (ATPase associated with various cellular activities) proteins participate in membrane trafficking, organelle biogenesis, DNA replication, intracellular locomotion, cytoskeletal remodelling, protein folding and proteolysis. The AAA Vps (vacuolar protein sorting) 4 is central to traffic to lysosomes, retroviral budding and mammalian cell division.
Ghazi-Tabatabai, S, Obita, T, Pobbati, A, Perisic, O, Samson, R, Bell, S, Williams, R   +6 more
openaire   +2 more sources

ESCRT subunits and associated proteins. [PDF]

, 2015
Abbreviations: ESCRT: endosomal sorting complex required for transport; CHMP: charged multivesicular body protein; MVB: multivesicular body; Ub: Ubiquitin; DUBs: deubiquitylating enzyme; PI: phosphoinositide.ESCRT subunits and associated proteins.
Xiaofeng Wang (119575), Abigail Ollwerther (699061), Jiantao Zhang (188731), Paul Ahlquist (78214), Arturo Diaz (373613)   +4 more
core   +1 more source

ESCRT-III: a versatile membrane remodeling machinery and its implications in cellular processes and diseases

Animal Cells and Systems
The endosomal sorting complexes required for transport (ESCRT) machinery is an evolutionarily conserved cytosolic protein complex that plays a crucial role in membrane remodeling and scission events across eukaryotes.
Jisoo Park, Jongyoon Kim, Hyungsun Park, Taewan Kim, Seongju Lee   +4 more
doaj   +1 more source

Genome-wide screen reveals important roles for ESCRT proteins in drug/ion resistance of fission yeast. [PDF]

PLoS ONE, 2018
To study sodium homeostasis, we performed a genome-wide screen for deletion strains that show resistance to NaCl. We identified 34 NaCl-resistant strains.
Yikun Yang, Qiannan Liu, Guanglie Jiang, Si Chen, Lina Zhou, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang, Fan Yao   +8 more
doaj   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag

Virology Journal, 2008
Background The ESCRT (endosomal sorting complex required for transport) machinery functions to sort cellular receptors into the lumen of the multivesicular body (MVB) prior to lysosomal degradation.
Valiathan Rajeshwari R, Resh Marilyn D
doaj   +1 more source