Results 91 to 100 of about 2,995 (191)

Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review)

Experimental and Therapeutic Medicine
Fraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin.
Ju, Shaohua, Tan, Youli, Wang, Qiang, Zhou, Ling, Wang, Kun, Wen, Chenghong, Wang, Mingjian   +6 more
openaire   +2 more sources

Design, synthesis and biological evaluation of esculetin derivatives as anti-tumour agents

, 2015
Esculetin, a naturally catecholic coumarin, possess multiple pharmacological activities including antitumour, anti-inflammatory and anti-oxidant. However, the extensive phase II metabolism and rapid elimination from the human body significantly hinder ...
Zou, Li-Wei, Yu, Yang, Xia, Yang-Liu, Ge, Guang-Bo, Wang, Ping, Feng, Lei, Yang, Ling, Lu, Jun-Xia   +7 more
core   +1 more source

Therapeutic potential of esculetin in various cancer types (Review)

Oncology Letters
Esculetin (Esc), a coumarin derivative and herbal medicinal compound used in traditional Chinese medicine, is extracted from Fraxinus chinensis. Esc has shown notable potential in the inhibition of proliferation, metastasis and cell cycle arrest in various cancer cell lines. The present review is based on research articles regarding Esc in the field of
Liu, Mengying, Sheng, Yuyan, Guo, Fangyue, Wu, Jing, Huang, Yufei, Yang, Xiaoning, Wang, Mengying, Zhang, Shanfeng, Li, Pei   +8 more
openaire   +2 more sources

Esculetin Attenuates Doxorubicin-Induced Kidney Damage By Reducing Heat Shock Proteins Expression Levels

Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
The effectiveness of Doxorobucin (DOX), a commonly used anti-cancer and immunosuppressive medication, is hindered by its potential for organ toxicity. Prolonged use of DOX is associated with severe hepatocellular toxicity.
Hamid Ceylan, Melike Karaman, Hilal Tosun, Habibe Karadaş, Neslihan Öztürk, Medine Sibel Karağaç, Duygu Kizir, Esra Nur Yeşilkent, Yeliz Demir   +8 more
doaj   +1 more source

Esculetin Protects Human Retinal Pigment Epithelial Cells from Lipopolysaccharide-induced Inflammation and Cell Death

, 2018
Purpose: Age-related macular degeneration (AMD) is the most common cause of visual loss. The dry AMD is characterized by retinal pigment epithelium (RPE) death and changes in AMD lead to severe loss of vision.
S. Altan Ozal, Turkekul, Kader, Kader Turkekul, Suat Erdogan, Vuslat Gurlu, Hande Guclu, Ozal, S. Altan, Erdogan, Suat, Gurlu, Vuslat, Guclu, Hande   +9 more
core   +1 more source

Exploring Esculetin's Protective Role: Countering Doxorubicin-Induced Oxidative Stress in Rat Heart

Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
Doxorubicin (DOX) and other anthracyclines are potent chemotherapy drugs used against cancer; however, their clinical application is linked to significant and potentially life-threatening cardiotoxicity.
Hamid Ceylan, Habibe Karadaş, Hilal Tosun, Murat Isıyel, Esra Nur Yeşilkent, Medine Sibel Karağaç, Neslihan Öztürk, Yeliz Demir   +7 more
doaj   +1 more source

Electrochemical Study of Esculetin Nitration by Digital Simulation of Cyclic Voltammograms

Journal of Chemistry, 2013
The reaction of electrochemically generated o-quinones from oxidation of esculetin as Michael acceptor with nitrite ion as nucleophile has been studied using cyclic voltammetry. The reaction mechanism is believed to be EC, including oxidation of catechol
Lida Khalafi, Mohammad Yari, Farzaneh Yadaei, Shabnam Majidzade   +3 more
doaj   +1 more source

Esculetin restores mitochondrial dysfunction and reduces allergic asthma features in experimental murine model

, 2009
We recently showed that IL-4-dependent oxidative stress and mitochondrial dysfunction are associated with allergic asthma. IL-4 also induces a prooxidant enzyme, 15-lipoxygenase, which predominantly expresses in asthmatic bronchial epithelium and ...
Ghosh, Balaram, Sharma, Surendra Kumar, Mabalirajan, Ulaganathan, Dinda, Amit Kumar   +3 more
core   +1 more source

Esculetin Inhibits the Survival of Human Prostate Cancer Cells by Inducing Apoptosis and Arresting the Cell Cycle

, 2018
Background: Prostate cancer (PCa) is one of the most important causes of death in men and thus new therapeutic approaches are needed. In this study, antiproliferative and anti-migration properties of a coumarin derivative esculetin were evaluated ...
Ozdemir, Mehmet D., Talha Baykul, Turkekul, Kader, Kader Turkekul, Suat Erdogan, Mehmet D. Ozdemir, R. Dilsu Colpan, Erdogan, Suat, Colpan, R. Dilsu, Baykul, Talha   +9 more
core   +1 more source

Defining the roles of polyphenol oxidase in dopamine and esculetin synMasters Thesis in plants

, 2016
Although the enzyme polyphenol oxidase (PPO) is well studied for its role in postharvest browning of commercial crops, its specific physiological function in plants is poorly understood.
Laura Walters
core