Results 91 to 100 of about 4,540 (215)

Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis

Rheumatology, 2016
Objectives : Esculetin (6,7-dihydroxycoumarin) is a natural coumarin with anti-oxidant, anti-inflammatory and anti-nociceptive activity. It acts as a potent inhibitor of lipoxygenases (5-LOX and 12-LOX) and decreases the production of matrix ...
Przemysław Rzodkiewicz, Emilia Gąsińska, Michał Gajewski, Magdalena Bujalska-Zadrożny, Dariusz Szukiewicz, Sławomir Maśliński   +5 more
doaj   +1 more source

Recombinant expression and functional characterisation of regiospecific flavonoid glucosyltransferases from Hieracium pilosella L. [PDF]

, 2009
Five glucosyltransferases were cloned by RT-PCR amplification using total RNA from Hieracium pilosella L. (Asteraceae) inflorescences as template. Expression was accomplished in Escherichia coli, and three of the HIS-tagged enzymes, UGT90A7, UGT95A1, and
Martens, S., Matern, U., Moco, S.I.A., Vervoort, J.J.M., Witte, S.   +4 more
core   +2 more sources

Chromenopyridine Derivatives as Novel 6PGD Inhibitors, MD Simulation, and Antioxidant Capacities

Journal of Chemistry, Volume 2026, Issue 1, 2026.
This study investigated the inhibitory effects of chromeno[4,3‐b]pyridine‐benzisoxazole derivatives on 6‐phosphogluconate dehydrogenase (6PGD), an important target enzyme in cancer treatment. In vitro analyses determined Ki values of 1.77 μM and 2.21 μM for Compounds 1 and 2, respectively.
Arzu Ozturk Kesebır, Hülya Akıncıoglu, Veysel Comaklı, Munmun Bardhan   +3 more
wiley   +1 more source

Application of Single-Walled Carbon Nanotubes/Au Nanosol Modified Electrode for the Electrochemical Determination of Esculetin in Cortex Fraxini

International Journal of Electrochemical Science, 2016
A novel simple, sensitive and selective electrochemical sensor was successfully prepared for the determination of esculetin in Cortex Fraxini based on the carboxylic acid-functionalized single-walled carbon nanotubes-Nafion–Au nanosol nanocomposite ...
Yuanyuan Yao, Xiaomei Zhang, Na Li, Xuming Liang, Yangping Wen, Hui Zhang, Yilong Chen, Dajian Yang, Jingkun Xu   +8 more
doaj   +1 more source

Phenolic substances of some Siberian Saussurea species [PDF]

, 2017
Screening studies of phenolic compounds were made for seven Siberian Saussurea species DC.: S. controversa DC., S. latifolia Ledeb., S. parviflora (Poir.) DC., S. frolowii Ledeb., S. amara (L.) DC., S. salicifolia DC. и S. davurica Adams.
Пиримкулова, У. С., Решетов, Я. Е., Шурупова, М. Н.   +2 more
core  

A novel method for pulmonary research: Assessment of bioenergetic function at the air–liquid interface [PDF]

, 2009
Air–liquid interface cell culture is an organotypic model for study of differentiated functional airway epithelium in vitro. Dysregulation of cellular energy metabolism and mitochondrial function have been suggested to contribute to airway diseases ...
Xu, Weiling, Janocha, Allison J., Leahy, Rachel A., Klatte, Ryan, Dudzinski, Dave, Mavrakis, Lori A., Comhair, Suzy A.A., Lauer, Mark E., Cotton, Calvin U., Erzurum, Serpil C.   +9 more
core   +4 more sources

Nicotiana tabacum: From a Beneficial Plant to Harmful Products—A Comprehensive Review of Smokeless Tobacco and Its Adverse Health Effects

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Nicotiana tabacum is a cash crop that originated in America and was introduced to the world by Christopher Colombus. It is now cultivated in many countries with major producers including China, the USA, India, and Brazil. The plant was widely used by the indigenous people of America for different reasons (spiritual, hallucination, and medical).
Abir Chami, Afaf Allaoui, Hassane Mekhfi, Younes Zaid, José Agustín Tapia Hernández   +4 more
wiley   +1 more source

Evaluation of the Antioxidant Activity of New Coumarin Derivatives by Cyclic Voltammetry [PDF]

, 2010
Free radicals, species with one or more unpaired electrons are produced in normal or pathological cell metabolism, from xenobiotics, or trough ionizing radiation.
Martins, Sérgio, Palmeiro, Gonçalo, Pereira, António, Teixeira, Jorge   +3 more
core  

Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations to Elucidate the Potential Mechanism of Ermiao San in Osteoarthritis

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Integrated network pharmacology, molecular docking, and dynamics simulations revealed the anti‐osteoarthritis mechanism of Ermiao San. Key bioactive compounds (e.g., quercetin) synergistically target core proteins (e.g., TNF and IL‐6), modulating critical pathways (e.g., TNF signaling) to inhibit inflammation and cartilage degradation, demonstrating a ...
Zhenyu Song, Jincheng Huang, He Zhu, Xu Li, Qianqian Cao, Liyang Yang, Meng Zhang, Hongkai Wang, Haoyue Sun   +8 more
wiley   +1 more source

Deciphering the role of 12/15-lipoxygenase in asthma: insights into mitochondrial dysfunction and therapeutic implications [PDF]

Exploration of Asthma & Allergy
This review delves into the complex role of 12/15-lipoxygenase (12/15-LOX) in asthma pathogenesis, focusing on its contributions to mitochondrial dysfunction, oxidative stress, epithelial injury, and airway remodeling.
Mandya V. Greeshma, Antara Baidya, Ulaganathan Mabalirajan, SubbaRao V. Madhunapantula, Rajesh Kumar Thimmulappa, Padukudru Anand Mahesh   +5 more
doaj   +1 more source