Results 81 to 90 of about 4,540 (215)

2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study [PDF]

, 2002
The purpose of this study was the evaluation of the xanthine oxidase (XO) inhibition produced by some synthetic 2-styrylchromones. Ten polyhydroxylated derivatives with several substitution patterns were synthesised, and these and a positive control,
Bastos, Maria de Lourdes, Carvalho, Félix, Cavaleiro, José, Fernandes, Eduarda, Pinto, Diana, Santos, Clementina M.M., Silva, Artur   +6 more
core   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Synthesis of umbelliferone derivatives in Escherichia coli and their biological activities

Journal of Biological Engineering, 2017
Background Umbelliferone, also known as 7-hydroxycoumarin, is a phenolic metabolite found in many familiar plants. Its derivatives have been shown to have various pharmacological and chemo-preventive effects on human health.
Luan Luong Chu, Ramesh Prasad Pandey, Haet Nim Lim, Hye Jin Jung, Nguyen Huy Thuan, Tae-Su Kim, Jae Kyung Sohng   +6 more
doaj   +1 more source

Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Mechanistic pathways of PIK3R1 in skin aging and rejuvenation were analyzed by bioinformatics approach and Gene Expression Omnibus database. Compared with young skin, PIK3R1 was differentially expressed in aged and IPL rejuvenated skin. Coexpression and network analyses revealed that PIK3R1 jointly participated in skin aging and rejuvenation via PI3K ...
Zhike Zhou, Sha Sha, Xiangnan Zhou, Chundi He, Ting Xiao, Yan Wu, Fenqin Chen, Le Qu, Hong‐Duo Chen   +8 more
wiley   +1 more source

Dual‐Pathway Defense: Ultramicro‐Pulverised Powder of Polygonum chinense L. and Atractylodes rhizome (PAUP) Rescues Broilers From E. coli‐Triggered Liver Injury Through Modulation of Oxidative Stress and Inflammation

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Reduced Antibiotic residues and resistance concerns: Offers a potential natural alternative to antibiotics for combating E. coli infections in poultry. Provided safer poultry food products: By enhancing liver function, restoring weight gain, and improving feed efficiency, PAUP supports the production of healthier chickens, ultimately contributing to ...
Jia‐Ci Cai, Yan‐Na Guo, Shao‐Shan Liang, Yan Liu, Fu‐Qiang Huang, Qi‐Peng Lv, Lan‐Yi Zhang, Yi Qin, Xiao‐Jing Chen, Yu‐Xin Liang, Yong‐Ming He, Lu‐Ping Tang   +11 more
wiley   +1 more source

Esculetin exhibits antifungal effects against Cryptococcus neoformans by inhibiting titan cell formation

Virulence
Cryptococcus neoformans is responsible for pulmonary cryptococcosis and life-threatening cryptococcal meningitis, particularly in immunocompromised individuals.
Xianwei Wu, Qi Ni, Jiajun Chen, Xing Huang, Peiyong Zheng, Dingzhong Wu, Shaoyan Zhang, Zhenhui Lu   +7 more
doaj   +1 more source

Synthetic biology: heterologous production of bioactive agents [PDF]

, 2017
Book of Abstracts of CEB Annual Meeting 2017Synthetic biology provides powerful tools to design innovative products and technologies. In the medical field, examples include the elucidation of disease mechanisms, identification of potential targets ...
Couto, Márcia R., Rainha, João, Rodrigues, Joana Lúcia Lima Correia, Rodrigues, L. R.   +3 more
core  

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, Volume 46, Issue 1, Page 198-206, January 2026.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source

Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review). [PDF]

Exp Ther Med
Fraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin.
Ju S, Tan Y, Wang Q, Zhou L, Wang K, Wen C, Wang M.   +6 more
europepmc   +3 more sources

A Narrative Review on Unravelling Bacterial‐Mediated Carcinogenesis and Possible Alternative Treatment Strategies

BioMed Research International, Volume 2026, Issue 1, 2026.
The potential roles of chemical, physical, and viral factors in cancer development are well documented. Similarly, bacterial carcinogenesis has been reported previously, though not extensively. Therefore, we aimed to provide comprehensive, mechanistic evidence on the pathogenesis of bacteria‐induced carcinogenesis and possible treatments to halt cancer
Md Sohel, Suraiya Aktar, Sanzida Khatun, Sherif Hamidu, Nishat Ulfat Nity, Sandeep Kumar, Md Sakhawat Hossain, Md. Rifat Sarker, Snygdha Rani Das, Badhan Rani Dey, Ali Mohamod Wasaf Hasan, Khairul Islam, Farhadul Islam, Abdullah Al Mamun, Baisakhi Banerjee   +14 more
wiley   +1 more source