Results 81 to 90 of about 2,995 (191)

Characterization of Human UDP-Glucuronosyltransferase Isoforms Responsible for the in vitro Glucuronidation of Esculetin

open access: yes, 2009
Esculetin (6,7-dihydroxycoumarin), is one of coumarin analogs isolated from various plant including Cichorium intybus, Artemisia scoparia and Fraxinus japonica Blume, has been found to exhibit broaden biological effects, such as analgesic, anti ...
梁思成   +4 more
core  

Nicotiana tabacum: From a Beneficial Plant to Harmful Products—A Comprehensive Review of Smokeless Tobacco and Its Adverse Health Effects

open access: yesThe Scientific World Journal, Volume 2026, Issue 1, 2026.
Nicotiana tabacum is a cash crop that originated in America and was introduced to the world by Christopher Colombus. It is now cultivated in many countries with major producers including China, the USA, India, and Brazil. The plant was widely used by the indigenous people of America for different reasons (spiritual, hallucination, and medical).
Abir Chami   +4 more
wiley   +1 more source

Deciphering the role of 12/15-lipoxygenase in asthma: insights into mitochondrial dysfunction and therapeutic implications [PDF]

open access: yesExploration of Asthma & Allergy
This review delves into the complex role of 12/15-lipoxygenase (12/15-LOX) in asthma pathogenesis, focusing on its contributions to mitochondrial dysfunction, oxidative stress, epithelial injury, and airway remodeling.
Mandya V. Greeshma   +5 more
doaj   +1 more source

Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations to Elucidate the Potential Mechanism of Ermiao San in Osteoarthritis

open access: yesFood Science &Nutrition, Volume 13, Issue 12, December 2025.
Integrated network pharmacology, molecular docking, and dynamics simulations revealed the anti‐osteoarthritis mechanism of Ermiao San. Key bioactive compounds (e.g., quercetin) synergistically target core proteins (e.g., TNF and IL‐6), modulating critical pathways (e.g., TNF signaling) to inhibit inflammation and cartilage degradation, demonstrating a ...
Zhenyu Song   +8 more
wiley   +1 more source

Fluorescent Behavior of Esculetin

open access: yes, 2019
Esculetin is a member of coumarin family, more importantly, as well as one of the big three natural coumarins that have most academic publications. The adjacent -OHs on 6 and 7 positions gives esculetin intriguing hydrogen bonding mechanism, and the ...
Muyskens, Mark, Tu, Yukun
core  

Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2–PKC–AKT Activation in Human Platelets

open access: yes, 2019
Esculetin, a bioactive 6,7-dihydroxy derivative of coumarin, possesses pharmacological activities against obesity, diabetes, renal failure, and cardiovascular disorders (CVDs). Platelet activation plays a major role in CVDs.
Marappan Velusamy   +8 more
core   +1 more source

Application of Single-Walled Carbon Nanotubes/Au Nanosol Modified Electrode for the Electrochemical Determination of Esculetin in Cortex Fraxini

open access: yesInternational Journal of Electrochemical Science, 2016
A novel simple, sensitive and selective electrochemical sensor was successfully prepared for the determination of esculetin in Cortex Fraxini based on the carboxylic acid-functionalized single-walled carbon nanotubes-Nafion–Au nanosol nanocomposite ...
Yuanyuan Yao   +8 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +31 more
wiley   +1 more source

Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines

open access: yes, 2018
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder afflicting from infancy to adults with itching, scratching, and lichenification.
T K Kwon   +23 more
core   +1 more source

Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting beta-Catenin

open access: yes, 2013
The Wnt pathway is a promising therapeutic and preventive target in various human cancers. The transcriptional complex of beta-catenin-T-cell factor (Tcf), a key mediator of canonical Wnt signaling, has been implicated in human colon cancer development ...
Lee, Mee-Hyun   +23 more
core   +1 more source

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