Results 71 to 80 of about 2,995 (191)

Effects of esculetin (6,7-dihydroxycoumarin) on guinea-pig tracheal chains in vitro.

, 1989
Esculetin (6,7-dihydroxycoumarin) was tested in isolated guinea-pig tracheal chains from normal and ovalbumin-sensitized animals. The drug showed a concentration-dependent relaxant effect, with an EC50 of 60 microM.
Guglielmina Froldi, Eugenio Ragazzi, Giuliana Fassina, Fassina G., RAGAZZI, EUGENIO, FROLDI, GUGLIELMINA   +5 more
core   +1 more source

Esculetin affects the microarchitecture of long bones in vivo and the alkaline phosphatase activity and bone nodule formation in vitro [PDF]

, 2021
391-397Osteoporosis is a condition of deterioration of bone quality and quantity, making it susceptible to fractures. The current therapy, with its associated risks and also approval for only short period makes the search for better molecules on ...
Pherwani, Pooja U., Pherwani, Pooja U., Sathaye, Sadhana   +2 more
core   +1 more source

Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Mechanistic pathways of PIK3R1 in skin aging and rejuvenation were analyzed by bioinformatics approach and Gene Expression Omnibus database. Compared with young skin, PIK3R1 was differentially expressed in aged and IPL rejuvenated skin. Coexpression and network analyses revealed that PIK3R1 jointly participated in skin aging and rejuvenation via PI3K ...
Zhike Zhou, Sha Sha, Xiangnan Zhou, Chundi He, Ting Xiao, Yan Wu, Fenqin Chen, Le Qu, Hong‐Duo Chen   +8 more
wiley   +1 more source

Dual‐Pathway Defense: Ultramicro‐Pulverised Powder of Polygonum chinense L. and Atractylodes rhizome (PAUP) Rescues Broilers From E. coli‐Triggered Liver Injury Through Modulation of Oxidative Stress and Inflammation

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Reduced Antibiotic residues and resistance concerns: Offers a potential natural alternative to antibiotics for combating E. coli infections in poultry. Provided safer poultry food products: By enhancing liver function, restoring weight gain, and improving feed efficiency, PAUP supports the production of healthier chickens, ultimately contributing to ...
Jia‐Ci Cai, Yan‐Na Guo, Shao‐Shan Liang, Yan Liu, Fu‐Qiang Huang, Qi‐Peng Lv, Lan‐Yi Zhang, Yi Qin, Xiao‐Jing Chen, Yu‐Xin Liang, Yong‐Ming He, Lu‐Ping Tang   +11 more
wiley   +1 more source

Esculetin Ameliorates Carbon Tetrachloride-Mediated Hepatic Apoptosis in Rats [PDF]

International Journal of Molecular Sciences, 2011
Esculetin (ESC) is a coumarin that is present in several plants such as Fraxinus rhynchophylla and Artemisia capillaris. Our previous study found that FR ethanol extract (FREtOH) significantly ameliorated rats’ liver function. This study was intended to investigate the protective mechanism of ESC in hepatic apoptosis in rats induced by carbon ...
Yun-Chen Tien, Jung-Chun Liao, Chuan-Sung Chiu, Tai-Hung Huang, Chih-Yang Huang, Wen-Te Chang, Wen-Huang Peng   +6 more
openaire   +2 more sources

Synthesis of umbelliferone derivatives in Escherichia coli and their biological activities

Journal of Biological Engineering, 2017
Background Umbelliferone, also known as 7-hydroxycoumarin, is a phenolic metabolite found in many familiar plants. Its derivatives have been shown to have various pharmacological and chemo-preventive effects on human health.
Luan Luong Chu, Ramesh Prasad Pandey, Haet Nim Lim, Hye Jin Jung, Nguyen Huy Thuan, Tae-Su Kim, Jae Kyung Sohng   +6 more
doaj   +1 more source

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, Volume 46, Issue 1, Page 198-206, January 2026.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source

A Narrative Review on Unravelling Bacterial‐Mediated Carcinogenesis and Possible Alternative Treatment Strategies

BioMed Research International, Volume 2026, Issue 1, 2026.
The potential roles of chemical, physical, and viral factors in cancer development are well documented. Similarly, bacterial carcinogenesis has been reported previously, though not extensively. Therefore, we aimed to provide comprehensive, mechanistic evidence on the pathogenesis of bacteria‐induced carcinogenesis and possible treatments to halt cancer
Md Sohel, Suraiya Aktar, Sanzida Khatun, Sherif Hamidu, Nishat Ulfat Nity, Sandeep Kumar, Md Sakhawat Hossain, Md. Rifat Sarker, Snygdha Rani Das, Badhan Rani Dey, Ali Mohamod Wasaf Hasan, Khairul Islam, Farhadul Islam, Abdullah Al Mamun, Baisakhi Banerjee   +14 more
wiley   +1 more source

Antioxidant Capacity and Characterization of Polyphenolic Compounds in Processed Falsa (Grewia asiatica L.) Products Using LC‐ESI‐QTOF‐MS/MS Analysis

Journal of Food Processing and Preservation, Volume 2026, Issue 1, 2026.
Fruits provide abundant vitamins, minerals, dietary fiber, and natural antioxidants. Falsa (Grewia asiatica), a lesser‐known berry fruit, is gaining attention owing to its diverse bioactive compounds and potential health‐promoting properties. This study aimed to evaluate the polyphenol content and antioxidant activity of processed products made from ...
X. Qin, A. Din, M. R. Khan, M. A. Shabbir, A. Rafi, A. Siddiqa, O. T. Agar, A. Beyatli, A. Imran, F. Ahmadi, H. A. R. Suleria, Essam Hebishy   +11 more
wiley   +1 more source

Chromenopyridine Derivatives as Novel 6PGD Inhibitors, MD Simulation, and Antioxidant Capacities

Journal of Chemistry, Volume 2026, Issue 1, 2026.
This study investigated the inhibitory effects of chromeno[4,3‐b]pyridine‐benzisoxazole derivatives on 6‐phosphogluconate dehydrogenase (6PGD), an important target enzyme in cancer treatment. In vitro analyses determined Ki values of 1.77 μM and 2.21 μM for Compounds 1 and 2, respectively.
Arzu Ozturk Kesebır, Hülya Akıncıoglu, Veysel Comaklı, Munmun Bardhan   +3 more
wiley   +1 more source