Results 71 to 80 of about 4,540 (215)
Advanced Science, Volume 13, Issue 13, 3 March 2026.A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong +11 more
wiley +1 more source
Study on Esculetin to reduce cardiotoxicity induced by Doxorubicin
Nepalese Journal of Cancer, 2021 Objective: To investigate the protective effects and mechanisms of esculetin(Esc) on H9C2 cells injury induced by doxorubicin (DOX). Methods: H9C2 cells were cultured and divided into control group, model (DOX) group and intervention (ESC + DOX) group.
Xiao Li +4 more
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From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery
Biopolymers, Volume 117, Issue 2, March 2026.ABSTRACT Polymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient encapsulation of both hydrophilic and lipophilic drugs, making them promising for drug delivery.
Milena Ferreira de Lima +8 more
wiley +1 more source
Depigmenting Effects of Esculetin and Esculin Isolated from Fraxinus rhynchophyllaHance [PDF]
Journal of the Society of Cosmetic Scientists of Korea, 2014 Stem bark extracts of Fraxinus rhynchophylla Hance were found to contain two major bioactive components,esculetin and esculin. Esculetin substantially inhibited melanogenesis in B16F10 melanoma cells, with an IC50 value of2.8 μm, and reduced melanin synthesis in Melan-A cells.
Yong Deog Hong +4 more
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Journal of Hepatocellular Carcinoma, 2023 Zhiru Xiu,1 Yiquan Li,1 Jinbo Fang,1 Jicheng Han,1 Shanzhi Li,1 Yaru Li,1,2 Xia Yang,1 Gaojie Song,3 Yue Li,1 Ningyi Jin,1,4,5 Yilong Zhu,1 Guangze Zhu,1 Lili Sun,6 Xiao Li1,4,7 1Academician Workstation of Jilin Province, Changchun University of Chinese ...
Xiu Z +13 more
doaj
Study of Umbelliferone Hydroxylation to Esculetin Catalyzed by Polyphenol Oxidase
Biological and Pharmaceutical Bulletin, 2013 We characterize umbelliferone, a derivative of 2,4-dihydroxycoumaric acid, as a substrate of polyphenol oxidase. This enzyme hydroxylates umbelliferone to esculetin, its o-diphenol, and then oxidizes it to o-quinone. The findings show that umbelliferone, an intermediate in one of the coumarin biosynthesis pathways, may be transformed into its o ...
Mary Of The Sea, Garcia-Molina +4 more
openaire +3 more sources
Brain Sciences, 2021 Trimethyltin (TMT) is an environmental neurotoxin that mediates dopaminergic neuronal injury in the brain. In this study, we characterized the toxic mechanism and possible protective compounds against TMT-induced neurotoxicity in human dopaminergic ...
Woo-Ju Song +6 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 2, March 2026.ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani +3 more
wiley +1 more source
Saudi Pharmaceutical JournalSchizophrenia, a global mental health disorder affecting approximately 1 % of the population, is characterized by neurotransmitter dysregulation, particularly dopamine, serotonin, and glutamate.
Iqra Khalid +4 more
doaj +1 more source
腸内菌由来Arylsulfate Sulfotransferaseに関する生化学的研究 [PDF]
, 1995 硫酸抱合反応は，種々の水酸基を有する化合物の解毒の主な経路である。この硫酸化を触媒する酵素としてsulfotransferaseが知られており，この酵素は，arylamine，phenol，steroidやbile acidなどの基質の違いにより分類されている。この酵素は硫酸基を3\u27-phosphoadenosine-5\u27-phosphosulfate(PAPS)からアルコール性あるいはフェノール性水酸基に転移する反応を触媒する。最近，同様な酵素が植物，Flaveriaからも見つかっている ...
今村 理佐
core +1 more source