Results 71 to 80 of about 2,492 (169)

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, Volume 46, Issue 1, Page 198-206, January 2026.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source

Deciphering the role of 12/15-lipoxygenase in asthma: insights into mitochondrial dysfunction and therapeutic implications [PDF]

Exploration of Asthma & Allergy
This review delves into the complex role of 12/15-lipoxygenase (12/15-LOX) in asthma pathogenesis, focusing on its contributions to mitochondrial dysfunction, oxidative stress, epithelial injury, and airway remodeling.
Mandya V. Greeshma, Antara Baidya, Ulaganathan Mabalirajan, SubbaRao V. Madhunapantula, Rajesh Kumar Thimmulappa, Padukudru Anand Mahesh   +5 more
doaj   +1 more source

Effects of various naturally occurring compounds (arbutin, borneol, esculetin, esculin, ellagic acid, gallic acid, hesperidine, piperitol, piperonal, quercetin, thymoquinone and ursolic acid) against maximal electroshock-induced seizures in mice

Current Issues in Pharmacy and Medical Sciences, 2013
The aim of this study was to perform the anticonvulsant screening test to select some naturally occurring substances isolated from herbs and medicinal plants that could offer a distinct protection against maximal electroshock (MES)-induced tonic ...
Jarogniew J. Łuszczki, Maciej Włodarczyk, Michał Gleńsk, Ewa Marzęda, Dariusz Durmowicz, Magdalena Florek-Łuszczki   +5 more
doaj   +1 more source

Therapeutic potential of esculetin in various cancer types (Review)

Oncology Letters
Esculetin (Esc), a coumarin derivative and herbal medicinal compound used in traditional Chinese medicine, is extracted from Fraxinus chinensis. Esc has shown notable potential in the inhibition of proliferation, metastasis and cell cycle arrest in various cancer cell lines. The present review is based on research articles regarding Esc in the field of
Liu, Mengying, Sheng, Yuyan, Guo, Fangyue, Wu, Jing, Huang, Yufei, Yang, Xiaoning, Wang, Mengying, Zhang, Shanfeng, Li, Pei   +8 more
openaire   +2 more sources

Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review)

Experimental and Therapeutic Medicine
Fraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin.
Ju, Shaohua, Tan, Youli, Wang, Qiang, Zhou, Ling, Wang, Kun, Wen, Chenghong, Wang, Mingjian   +6 more
openaire   +2 more sources

Esculetin Attenuates Doxorubicin-Induced Kidney Damage By Reducing Heat Shock Proteins Expression Levels

Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
The effectiveness of Doxorobucin (DOX), a commonly used anti-cancer and immunosuppressive medication, is hindered by its potential for organ toxicity. Prolonged use of DOX is associated with severe hepatocellular toxicity.
Hamid Ceylan, Melike Karaman, Hilal Tosun, Habibe Karadaş, Neslihan Öztürk, Medine Sibel Karağaç, Duygu Kizir, Esra Nur Yeşilkent, Yeliz Demir   +8 more
doaj   +1 more source

Exploring Esculetin's Protective Role: Countering Doxorubicin-Induced Oxidative Stress in Rat Heart

Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
Doxorubicin (DOX) and other anthracyclines are potent chemotherapy drugs used against cancer; however, their clinical application is linked to significant and potentially life-threatening cardiotoxicity.
Hamid Ceylan, Habibe Karadaş, Hilal Tosun, Murat Isıyel, Esra Nur Yeşilkent, Medine Sibel Karağaç, Neslihan Öztürk, Yeliz Demir   +7 more
doaj   +1 more source

Electrochemical Study of Esculetin Nitration by Digital Simulation of Cyclic Voltammograms

Journal of Chemistry, 2013
The reaction of electrochemically generated o-quinones from oxidation of esculetin as Michael acceptor with nitrite ion as nucleophile has been studied using cyclic voltammetry. The reaction mechanism is believed to be EC, including oxidation of catechol
Lida Khalafi, Mohammad Yari, Farzaneh Yadaei, Shabnam Majidzade   +3 more
doaj   +1 more source

COUMARIN (ESCULETIN) - AN ANTIRHEUMATOID ARTHRITIC COMPOUND: AN UPDATE

Asian Journal of Pharmaceutical and Clinical Research, 2018
Context: Esculetin is a natural polyphenolic compound. It is chemically 6,7-dihydroxycoumarin and one of the ingredients of Cortex fraxini, a Chinese traditional medicine. It is used as a dietary supplement and found as non-toxic. Recently, there are many research works evaluated on esculetin in arthritis with supported molecular mechanisms.Objectives:
openaire   +2 more sources

Esculetin induce apoptosis in Human Cervical Cancer Cells (HeLa)

Eastern Journal Of Medicine
Yuzuncu Yil Universitesi Tip ...
DURAN, Tuğçe, ŞAHİN, Gözde, KEBAPÇILAR, Ayşegül, ÇELİK, Çetin   +3 more
openaire   +2 more sources