Results 51 to 60 of about 2,492 (169)

Study of Umbelliferone Hydroxylation to Esculetin Catalyzed by Polyphenol Oxidase

Biological and Pharmaceutical Bulletin, 2013
We characterize umbelliferone, a derivative of 2,4-dihydroxycoumaric acid, as a substrate of polyphenol oxidase. This enzyme hydroxylates umbelliferone to esculetin, its o-diphenol, and then oxidizes it to o-quinone. The findings show that umbelliferone, an intermediate in one of the coumarin biosynthesis pathways, may be transformed into its o ...
Garcia-Molina, Mary of the Sea, Munoz-Munoz, Joseph Louis, Garcia-Molina, Francis, Rodriguez-Lopez, Joseph Neptune, Garcia-Canovas, Francis   +4 more
openaire   +3 more sources

Inhibitory Effects of Esculetin on Liver Cancer Through Triggering NCOA4 Pathway-Mediation Ferritinophagy in vivo and in vitro

Journal of Hepatocellular Carcinoma, 2023
Zhiru Xiu,1 Yiquan Li,1 Jinbo Fang,1 Jicheng Han,1 Shanzhi Li,1 Yaru Li,1,2 Xia Yang,1 Gaojie Song,3 Yue Li,1 Ningyi Jin,1,4,5 Yilong Zhu,1 Guangze Zhu,1 Lili Sun,6 Xiao Li1,4,7 1Academician Workstation of Jilin Province, Changchun University of Chinese ...
Xiu Z, Li Y, Fang J, Han J, Li S, Li Y, Yang X, Song G, Li Y, Jin N, Zhu Y, Zhu G, Sun L, Li X   +13 more
doaj  

Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli

Molecules, 2022
Coumarins and furanocoumarins are plant secondary metabolites with known biological activities. As they are present in low amounts in plants, their heterologous production emerged as a more sustainable and efficient approach to plant extraction. Although
Joana L. Rodrigues, Daniela Gomes, Lígia R. Rodrigues   +2 more
doaj   +1 more source

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, Volume 4, Issue 2, Page 327-342, April 2026.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source

Natural Remedies for Gut Health: The Role of Plant Extracts in Combating Inflammatory Bowel Disease and Colon Cancer

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Created in BioRender. Haralambie, O. (2025) https://BioRender.com/dh5ly89. ABSTRACT Digestive disorders such as inflammatory bowel disease (IBD) and colorectal cancer are among the most significant global health challenges, largely driven by chronic inflammation and oxidative stress.
Oana‐Roxana Haralambie, Sanda Andrei
wiley   +1 more source

Mechanistic insights into the biochemical and pharmacological profile of esculetin

, 2022
Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, and many others. Glycosides and caffeic acid conjugates are the common forms of esculetin present in medicinal plants.
Sourbh Suren Garg, Jeena Gupta, Debasis Sahu, Chuan Ju Liu   +3 more
openaire   +1 more source

NMDA receptor modulation by Esculetin: Investigating behavioral, biochemical and neurochemical effects in schizophrenic mice model

Saudi Pharmaceutical Journal
Schizophrenia, a global mental health disorder affecting approximately 1 % of the population, is characterized by neurotransmitter dysregulation, particularly dopamine, serotonin, and glutamate.
Iqra Khalid, Uzma Saleem, Bashir Ahmad, Mohammed F. Hawwal, Ramzi A. Mothana   +4 more
doaj   +1 more source

Onosma armenum Extract Loaded Mesoporous Silica Nanoparticles for the Prevention of Biofilm‐Associated Infections

ChemistryOpen, Volume 15, Issue 4, April 2026.
Bioactive mesoporous silica nanoparticles (MSNPs) loaded with O. armenum extract were developed to evaluate their antibiofilm activity against biofilm‐forming Staphylococcus aureus ATCC 25923. The phytochemical content of the extract was analyzed via liquid chromatography–electrospray ionization tandem mass spectrometry.
Sevim Feyza Erdoğmuş, Nilay Isitez, Emre Burak Ertuş, Cengiz Sarikurkcu   +3 more
wiley   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, Volume 13, Issue 13, 3 March 2026.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source