Results 41 to 50 of about 2,995 (191)

Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI

Frontiers in Pharmacology, 2020
Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells.
Song-Tao Wu, Bo Liu, Bo Liu, Bo Liu, Zhong-Zhu Ai, Zhong-Zhu Ai, Zhong-Zhu Ai, Zong-Chao Hong, Peng-Tao You, Peng-Tao You, Peng-Tao You, He-Zhen Wu, He-Zhen Wu, He-Zhen Wu, Yan-Fang Yang, Yan-Fang Yang, Yan-Fang Yang   +16 more
doaj   +1 more source

Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence

BMC Pharmacology and Toxicology, 2021
Background Esculetin is a natural coumarin derivative from various plants with multiple pharmacological effects. Hence, the present study was undertaken to explore the cardio protective potential of esculetin against isoproterenol induced myocardial ...
Chitikela P. Pullaiah, Vinod K. Nelson, Sushma Rayapu, Narasimha Kumar G V, Thyagaraju Kedam   +4 more
doaj   +1 more source

Investigation of cell death mechanism and activity of esculetin-loaded PLGA nanoparticles on insulinoma cells in vitro.

, 2021
Aim The purpose of this study was to prepare targeted cancer therapy formulation against insulinoma INS-1 cells and to study its effect on cell death with related mechanisms in vitro.
Tekkeli, Şerife Evrim, Topçu, Gülaçtı, Bahadori, Fatemeh, Karatug Kacar, Ayşe, Bolkent, Sehnaz   +4 more
core   +1 more source

Effect of esculetin on bone metabolism in ovariectomized rats

Journal of Traditional Chinese Medicine, 2018
To determine the effect of an esculetin formulation (at 97.4% purity) on osteoporosis, and to investigate the potential underlying molecular mechanism(s).Sixty specific pathogen free-grade female Wistar rats were randomly assigned to three groups: blank control (n = 12), sham (n = 12), and model (n = 36). The model group were bilaterally ovariectomized.
Meijie, Liu, Yan Bone And Joint Diseases Laboratory, Li, Jinghua, Pan, Hong, Liu, Shaojun, Wang, Dahong, Ju, Ruiha, Wang, Dong, Bai, Jiaying, Wu, Gang, Sun, Qing, Miao, Limei, Liu   +11 more
openaire   +2 more sources

Bioactive coumarin-derivative esculetin decreases hepatic stellate cell activation via induction of cellular senescence via the PI3K-Akt-GSK3β pathway [PDF]

, 2022
Background: Activation of hepatic stellate cells (HSC) leads to initiation and progression of hepatic fibrosis. HSC senescence is inversely correlated with HSC proliferation and activation.
Serna-Salas, Sandra, Damba, Turtushikh, Moshage, Han, Zhang, Mengfan, Moshage, Han; id_orcid, Faber, Klaas Nico, Serna-Salas, Sandra; id_orcid, Wu, Zongmei, Buist-Homan, Manon   +8 more
core   +1 more source

Natural Coumarin Derivative Esculetin Regulates Platelet Activation via Modulating NF-κB Signaling in Cyclic Nucleotide-Independent Manner

Natural Product Communications, 2019
Esculetin, a natural coumarin derivative, shows exciting biological activities in a variety of cell and animal models. Our recent study demonstrated that esculetin exhibits antiplatelet effects by obstructing the phospholipase C γ2/protein kinase C ...
Chih-Wei Hsia, Kou-Gi Shyu, Thanasekaran Jayakumar, Chih-Hsuan Hsia, Marappan Velusamy, Chih-Hao Yang, Joen-Rong Sheu   +6 more
doaj   +1 more source

Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models

Pharmaceuticals, 2021
Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene.
Letizia Pruccoli, Carlo Breda, Gabriella Teti, Mirella Falconi, Flaviano Giorgini, Andrea Tarozzi   +5 more
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Study on Esculetin to reduce cardiotoxicity induced by Doxorubicin

Nepalese Journal of Cancer, 2021
Objective: To investigate the protective effects and mechanisms of esculetin(Esc) on H9C2 cells injury induced by doxorubicin (DOX).  Methods: H9C2 cells were cultured and divided into control group, model (DOX) group and intervention (ESC + DOX) group.
Xiao Li, Xiaolei Yu, Fan Xu, Qingshan Li, Xiao Xu   +4 more
openaire   +1 more source

6,7-Dihydroxy-5,8-dimethoxy-2H-chromen-2-one

Molbank, 2023
This article presents a novel approach for synthesizing a new 5,8-dimethoxy derivative of esculetin via the selective cleavage of the methylene bridge in sabandin—naturally occurring and easily synthetically accessible methoxylated coumarin.
Olga I. Adaeva, Dmitry V. Demchuk, Victor V. Semenov   +2 more
doaj   +1 more source

Esculetin Alleviates Inflammation, Oxidative Stress and Apoptosis in Intestinal Ischemia/Reperfusion Injury via Targeting SIRT3/AMPK/mTOR Signaling and Regulating Autophagy

Journal of Inflammation Research, 2023
Xin Shen,1,* Hai Shi,1,* Xinli Chen,1 Junwei Han,1 Haiwang Liu,1 Jie Yang,1 Yuan Shi,2 Jiajia Ma2 1Department of Gastrointestinal Surgery, Xi’an Daxing Hospital, Xi’an, 710016, People’s Republic of China; 2Department of Gynecology and Obstetrics,
Shen X, Shi H, Chen X, Han J, Liu H, Yang J, Shi Y, Ma J   +7 more
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