Results 41 to 50 of about 2,492 (169)

Protective Effects and Mechanisms of Esculetin against H₂O₂-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells

Molecules
Oxidative stress plays a crucial role in the pathogenesis of many diseases. Esculetin is a natural coumarin compound with good antioxidant and anti-inflammatory properties.
Ying Luo, Tenglong Chang, Shiting Huang, Jing Xiang, Shuangyang Tang, Haiyan Shen   +5 more
doaj   +1 more source

Esculetin Alleviates Inflammation, Oxidative Stress and Apoptosis in Intestinal Ischemia/Reperfusion Injury via Targeting SIRT3/AMPK/mTOR Signaling and Regulating Autophagy

Journal of Inflammation Research, 2023
Xin Shen,1,* Hai Shi,1,* Xinli Chen,1 Junwei Han,1 Haiwang Liu,1 Jie Yang,1 Yuan Shi,2 Jiajia Ma2 1Department of Gastrointestinal Surgery, Xi’an Daxing Hospital, Xi’an, 710016, People’s Republic of China; 2Department of Gynecology and Obstetrics,
Shen X, Shi H, Chen X, Han J, Liu H, Yang J, Shi Y, Ma J   +7 more
doaj  

6,7-Dihydroxy-5,8-dimethoxy-2H-chromen-2-one

Molbank, 2023
This article presents a novel approach for synthesizing a new 5,8-dimethoxy derivative of esculetin via the selective cleavage of the methylene bridge in sabandin—naturally occurring and easily synthetically accessible methoxylated coumarin.
Olga I. Adaeva, Dmitry V. Demchuk, Victor V. Semenov   +2 more
doaj   +1 more source

Optimizing Extraction and HPLC‐ESI‐QTOF‐MS/MS Analysis of Bound Phenolics From Okra (Abelmoschus esculentus) and Their Biological Activity

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Extraction and characterization of okra bound phenolics. The extraction of bound phenolics from okra pulp (OPBP) and seeds (OSBP) was optimized, achieving maximum yields of 7.77 and 83.03 mg GAE/g DW, respectively. Using HPLC‐ESI‐QTOF‐MS/MS, multiple phenolic compounds were identified, with nine being reported in okra for the first time.
Bingjie Zhang, Rongjuan Liu, Hong Zhang, Ting Xv, Yue Lv, Yuan Xv, Haiqiang Chen, Hu Zhu, Xiaolin Shi, Mingyan Yan, Yinping Li   +10 more
wiley   +1 more source

Coumarins Disrupt Cell–Cell Communication and Virulence in Priority Pathogens: Targeting the PQS Signalling System in Pseudomonas aeruginosa

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
The selective nature through which coumarin compounds produced by different species of plants target PQS signalling in Pseudomonas aeruginosa and select for distinct phenotypic responses in key pathogenic organisms adds to the growing evidence of their utility as natural virulence suppressors. ABSTRACT Cell‐to‐cell communication in microbial systems is
Dylan Boon, Benjamin O'Rourke, Muireann Carmody, David F. Woods, Antje Gloe, Daniel Platero‐Rochart, Pedro A. Sánchez‐Murcia, Gerard P. McGlacken, F. Jerry Reen   +8 more
wiley   +1 more source

Study on Esculetin to reduce cardiotoxicity induced by Doxorubicin

Nepalese Journal of Cancer, 2021
Objective: To investigate the protective effects and mechanisms of esculetin(Esc) on H9C2 cells injury induced by doxorubicin (DOX).  Methods: H9C2 cells were cultured and divided into control group, model (DOX) group and intervention (ESC + DOX) group.
Xiao Li, Xiaolei Yu, Fan Xu, Qingshan Li, Xiao Xu   +4 more
openaire   +1 more source

(E)-6-Hydroxy-2-oxo-2H-chromen-7-yl 3-(4-hydroxy-3-methoxyphenyl)acrylate

Molbank, 2023
A hybrid compound 5: (E)-6-hydroxy-2-oxo-2H-chromen-7-yl 3-(4-hydroxy-3-methoxyphenyl)acrylate composed of (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid (ferulic acid) 1 and 6,7-hydroxycoumarin (esculetin) 3 was prepared in a 61% yield by the ...
Yang-Heon Song
doaj   +1 more source

Multi‐Omics Unveils the Dual‐Life of the Aquatic Plant Potamogeton nodosus

Physiologia Plantarum, Volume 178, Issue 4, July/August 2026.
ABSTRACT Heterophylly, characterized by distinct leaf morphologies, is an adaptive strategy evolved by some aquatic plants to cope with the contrasting environments in which they grow. It is shaped by environmental factors and by hormones, particularly abscisic and gibberellic acids.
Thomas Horst Berthelier, Sébastien Christophe Cabanac, Caroline Callot, William Marande, Hélène San Clemente, Amélie Perez, Guillaume Marti, Elisabeth Jamet, Christophe Dunand   +8 more
wiley   +1 more source

Esculetin ameliorates sevoflurane-induced cognitive dysfunction in aged mice by suppressing neuroinflammation via inhibition of NF-κB/NLRP3 signaling

Folia Histochemica et Cytobiologica
INTRODUCTION: The widely used inhalational anesthetic sevoflurane increases susceptibility to postoperative cognitive dysfunction (POCD), especially among the elderly.
Xiaoli Cai, Zhang Tian, Qingyun Zhang, Jing Zhao   +3 more
doaj   +1 more source

Detection of coumarin derivatives of Viola odorata cultivated in Iraq

Journal of Pharmacy and Bioallied Sciences, 2023
Like other members of the viola family, Viola odorata may be found naturally occurring in Europe and Asia. This little plant is tough and perennially herbaceous. It's also known as sweet violet and English violet.
Zainab Aziz Ali, Ibrahim Saleh, Widad M K Alani   +2 more
doaj   +1 more source