Results 31 to 40 of about 2,492 (169)

Antitumor Effects of Esculetin, a Natural Coumarin Derivative, against Canine Mammary Gland Tumor Cells by Inducing Cell Cycle Arrest and Apoptosis

Veterinary Sciences, 2023
Mammary gland tumors are the most common neoplasms in female dogs, of which 50% are malignant. Esculetin, a coumarin derivative, reportedly induces death in different types of cancer cells.
Jawun Choi, Min-Jae Yoo, Sang-Youel Park, Jae-Won Seol   +3 more
doaj   +1 more source

Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence

BMC Pharmacology and Toxicology, 2021
Background Esculetin is a natural coumarin derivative from various plants with multiple pharmacological effects. Hence, the present study was undertaken to explore the cardio protective potential of esculetin against isoproterenol induced myocardial ...
Chitikela P. Pullaiah, Vinod K. Nelson, Sushma Rayapu, Narasimha Kumar G V, Thyagaraju Kedam   +4 more
doaj   +1 more source

Inhibition of Quorum Sensing and Biofilm Formation of Esculetin on Aeromonas Hydrophila

Frontiers in Microbiology, 2021
Quorum sensing (QS) and biofilm formation inhibition activity of esculetin on Aeromonas hydrophila SHAe 115 were evaluated. Exposure to esculetin at 25, 50, and 100μg/ml significantly inhibited the production of protease and hemolysin, the formation of ...
Bing Sun, Bing Sun, Huaizhi Luo, Huan Jiang, Zhennan Wang, Aiqun Jia   +5 more
doaj   +1 more source

Effect of esculetin on bone metabolism in ovariectomized rats

Journal of Traditional Chinese Medicine, 2018
To determine the effect of an esculetin formulation (at 97.4% purity) on osteoporosis, and to investigate the potential underlying molecular mechanism(s).Sixty specific pathogen free-grade female Wistar rats were randomly assigned to three groups: blank control (n = 12), sham (n = 12), and model (n = 36). The model group were bilaterally ovariectomized.
Meijie, Liu, Yan Bone And Joint Diseases Laboratory, Li, Jinghua, Pan, Hong, Liu, Shaojun, Wang, Dahong, Ju, Ruiha, Wang, Dong, Bai, Jiaying, Wu, Gang, Sun, Qing, Miao, Limei, Liu   +11 more
openaire   +2 more sources

Mechanism and Effect of Esculetin in an Experimental Animal Model of Inflammatory Bowel Disease

European Journal of Inflammation, 2013
Esculetin is a coumarin derivative with high antioxidant activity. In a rat experimental model of inflammatory bowel disease induced by trinitrobenzenesulfonic acid, esculetin at the dose of 5mg/Kg displayed intestinal anti-inflammatory activity; however,
A. Witaicenis, A.C. Luchini, C.A. Hiruma-Lima, S.L. Felisbino, L.A. Justulin, N. Garrido-Mesa, P. Utrilla, J. Gálvez, L.C. Di Stasi   +8 more
doaj   +1 more source

Natural Coumarin Derivative Esculetin Regulates Platelet Activation via Modulating NF-κB Signaling in Cyclic Nucleotide-Independent Manner

Natural Product Communications, 2019
Esculetin, a natural coumarin derivative, shows exciting biological activities in a variety of cell and animal models. Our recent study demonstrated that esculetin exhibits antiplatelet effects by obstructing the phospholipase C γ2/protein kinase C ...
Chih-Wei Hsia, Kou-Gi Shyu, Thanasekaran Jayakumar, Chih-Hsuan Hsia, Marappan Velusamy, Chih-Hao Yang, Joen-Rong Sheu   +6 more
doaj   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Simultaneous Overexpression of FERULOYL‐CoA 6′‐HYDROXYLASE 1 and COUMARIN SYNTHASE Leads to Coumarin‐Enriched Lignin and Improved Saccharification in Greenhouse‐ and Field‐Grown Poplar

Plant Biotechnology Journal, EarlyView.
ABSTRACT The urgent need for renewable resources has increased the interest in woody biomass to manufacture bio‐based products. However, lignin recalcitrance limits the enzymatic conversion of wood into fermentable sugars, posing a major challenge for biomass deconstruction.
Nette De Ridder, Lennart Hoengenaert, Jan Van Doorsselaere, Wim De Clercq, Geert Goeminne, Sarah Liu, Fachuang Lu, John Ralph, Ruben Vanholme, Wout Boerjan   +9 more
wiley   +1 more source

Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models

Pharmaceuticals, 2021
Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene.
Letizia Pruccoli, Carlo Breda, Gabriella Teti, Mirella Falconi, Flaviano Giorgini, Andrea Tarozzi   +5 more
doaj   +1 more source

A Novel Laboratorial Approach to Evaluate Bacterial Microleakage of Endodontic Sealers

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract To avoid failure of endodontic treatment, it is important to properly seal the root canals after chemomechanical preparation in order to avoid microleakage. Typically, sealing involves the use of gutta‐percha and sealing cement, the latter of which adheres to the dentin and fills the spaces between the gutta‐percha and the dentin walls ...
Emannuel Fonseca Thomé da Silva Monteiro, Alice Abib Ramos Fabri, Marcelo Barbosa Garcia, Sabrina Silva Azevedo, Higor Machado Gonçalves, Ana Clara Miranda Porto Figueiredo, Fabrícia Nogueira Klein, Gabriela Ceccon Chianca, Roberta Barcelos, Helvécio Cardoso Corrêa Póvoa, Leonardo Santos Antunes, Natalia Lopes Pontes Póvoa Iorio   +11 more
wiley   +1 more source