Results 31 to 40 of about 2,995 (191)
Pharmacological activities of esculin and esculetin: A review
Medicine, 2023 Esculin and esculetin are 2 widely studied coumarin components of Cortex Fraxini, which is a well-known herbal medicine with a 2000-year history. In vivo and in vitro studies have demonstrated that both have a variety of pharmacological activities, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, antidiabetic, immunomodulatory, anti-
Ting Cai, Bin Cai
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Antioxidants, 2023 Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-associated fatty liver disease (MAFLD). However, the mechanisms underlying their beneficial effects remain unclear.
Mengmeng Xia +4 more
doaj +1 more source
Esculetin Alleviates Acute Liver Failure following Lipopolysaccharide/D-Galactosamine in Male C57BL/6 Mice [PDF]
Iranian Journal of Medical Sciences, 2021 Background: Acute liver failure (ALF) is a fatal clinical situation that rapidly leads to the loss of normal liver function. Esculetin is a natural herbal compound used for the management of various diseases such as cardiovascular and renal disorders. In
Seyed-Mahdi Mohamadi-Zarch +5 more
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Improvement effects of esculetin on the formation and development of atherosclerosis
Biomedicine & Pharmacotherapy, 2022 Atherosclerosis is one of the potential causes of death in patients with cardiovascular disease. With the discovery of new anti atherosclerotic drugs becoming the pursuit of the pharmaceutical industry, natural products have attracted more and more attention because of their unique efficacy in the treatment of atherosclerosis.
Qian-Hui, Wang +2 more
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The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition. [PDF]
New PhytolSummary Iron (Fe) is a transition metal necessary for achieving essential physiological processes throughout the plant lifecycle. In Arabidopsis thaliana, secreting Fe‐mobilizing coumarins (FMC) is a key mechanism enabling roots to acquire nonbioavailable Fe present in soils.
Watanabe S +7 more
europepmc +2 more sources
Molecules, 2022 Inflammation is a major root of several diseases such as allergy, cancer, Alzheimer’s, and several others, and the present state of existing drugs provoked researchers to search for new treatment strategies.
Thanasekaran Jayakumar +8 more
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Toxics, 2022 We examined the protective effects of esculetin and fucoidan against the neurotoxicity of ZnO NPs in rats. Ninety rats were divided into nine groups and pre-treated with esculetin or fucoidan 1 h before ZnO NP administration on a daily basis for 2 weeks.
Woo-Ju Song +6 more
doaj +1 more source
BMC Cancer, 2023 Background The “Differentiation therapy” has been emerging as a promising and more effective strategy against acute leukemia relapses. Objective In extension to the revolutionising therapeutic outcomes of All Trans Retinoic Acid (ATRA) to induce terminal
Ankit Mathur, Aman Gangwar, Daman Saluja
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Inhibitory Effects of Esculetin on Melanin Biosynthesis
Biological and Pharmaceutical Bulletin, 2004 To investigate the structure-activity relationship of coumarins for the inhibitory activity on mushroom tyrosinase, the 50% inhibitory concentration (IC50 values) of 18 coumarins and four cinnamic acid derivatives were measured. Among these compounds, esculetin had the strongest inhibitory activity (IC50=43 microM) on mushroom tyrosinase.
Masamoto, Yukimitsu +5 more
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Veterinary Sciences, 2023 Mammary gland tumors are the most common neoplasms in female dogs, of which 50% are malignant. Esculetin, a coumarin derivative, reportedly induces death in different types of cancer cells.
Jawun Choi +3 more
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