Results 11 to 20 of about 4,540 (215)
Umbelliferone and esculetin protect against N-nitrosodiethylamine-induced hepatotoxicity in rats [PDF]
Cell Biology International, 2016 N-nitrosodiethylamine (NDEA), a nitrosamine compound, is known to cause liver damage through the generation of reactive oxygen species (ROS), resulting in oxidative damage to macromolecules such as DNA, and the consequent development of cancer.
Ellis, Elizabeth M. +1 more
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An NMR Study on Esculetin and It's Derivatives
Chinese Journal of Magnetic Resonance, 2019 The derivatives of esculetin contain hydroquinone groups that have various biological activities. In this study, the esculetin derivatives 2~14 were obtained by inducting the methoxy and hydroxyl groups into the 5, 6, 7 and 8 positions, and pheny group ...
LIU Ji-hong, JIN Kun, WANG Ping, LUO Gen
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Targeting cellular plasticity: esculetin-driven reversion of stem cell-like characteristics and EMT phenotype in transforming cells with sequential p53/p73 knockdowns [PDF]
BMC CancerThe intricate interplay of cancer stem cell plasticity, along with the bidirectional transformation between epithelial-mesenchymal states, introduces further intricacy to offer insights into newer therapeutic approaches.
Ankit Mathur +4 more
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Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway [PDF]
Brazilian Journal of Medical and Biological Research, 2015 This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium) colorimetric assay.
J. Wang +5 more
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Molecules, 2023 (1) Malignant melanomas are dangerous skin cancers, and the treatment of melanomas with various cytostatic drugs often causes side effects and after their prolonged use resistance to these drugs appears.
Paula Wróblewska-Łuczka +2 more
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Pharmaceuticals, 2023 Pimpinella anisum L., or anise, is a plant that, besides its nutritional value, has been used in traditional medical practices and described in many cultures in the Mediterranean region. A possible reason for anise’s therapeutic value is that it contains
Miriam Rossi +7 more
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Pharmacological and Therapeutic Applications of Esculetin
International Journal of Molecular Sciences, 2022 Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, etc. Free radicals lead to the development of oxidative stress causing inflammation, arthritis, cancer, diabetes, fatty liver disease, etc.
Sourbh Suren Garg +3 more
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Current Issues in Molecular Biology, 2022 Esculetin is an antioxidant and anti-inflammatory compound derived from coumarin. Oxidative stress can cause overproduction of reactive oxygen species (ROS), which can lead to the development of chronic kidney failure.
Woo Kwon Jung +4 more
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Antioxidants, 2023 Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-associated fatty liver disease (MAFLD). However, the mechanisms underlying their beneficial effects remain unclear.
Mengmeng Xia +4 more
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Brazilian Journal of Pharmaceutical Sciences, 2020 Traditional Chinese Herbal Medicine has been used to prevent and cure disease in China for thousands of years and has gained global interest in recent decades. The Erding formula is a Chinese Pharmacopeia (ChP)-listed herbal preparation used for treating
Jieyu Zuo +4 more
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