Results 11 to 20 of about 2,995 (191)
Esculetin attenuates cerebral ischemia-reperfusion injury and protects neurons through Nrf2 activation in rats [PDF]
Brazilian Journal of Medical and Biological ResearchNuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a key transcription factor in the antioxidant response and is associated with various chronic diseases.
Zhe Zhang +5 more
doaj +3 more sources
Pharmacological and Therapeutic Applications of Esculetin
International Journal of Molecular Sciences, 2022 Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, etc. Free radicals lead to the development of oxidative stress causing inflammation, arthritis, cancer, diabetes, fatty liver disease, etc.
Sourbh Suren Garg +3 more
openaire +3 more sources
Examining the Antioxidant and Superoxide Radical Scavenging Activity of Anise, (Pimpinella anisum L. Seeds), Esculetin, and 4-Methyl-Esculetin Using X-ray Diffraction, Hydrodynamic Voltammetry and DFT Methods [PDF]
Pharmaceuticals, 2023 Pimpinella anisum L., or anise, is a plant that, besides its nutritional value, has been used in traditional medical practices and described in many cultures in the Mediterranean region. A possible reason for anise’s therapeutic value is that it contains
Miriam Rossi +7 more
doaj +2 more sources
Current Issues in Molecular Biology, 2022 Esculetin is an antioxidant and anti-inflammatory compound derived from coumarin. Oxidative stress can cause overproduction of reactive oxygen species (ROS), which can lead to the development of chronic kidney failure.
Woo Kwon Jung +4 more
doaj +2 more sources
Molecules, 2023 (1) Malignant melanomas are dangerous skin cancers, and the treatment of melanomas with various cytostatic drugs often causes side effects and after their prolonged use resistance to these drugs appears.
Paula Wróblewska-Łuczka +2 more
doaj +2 more sources
Brazilian Journal of Pharmaceutical Sciences, 2020 Traditional Chinese Herbal Medicine has been used to prevent and cure disease in China for thousands of years and has gained global interest in recent decades. The Erding formula is a Chinese Pharmacopeia (ChP)-listed herbal preparation used for treating
Jieyu Zuo +4 more
doaj +3 more sources
Mechanism and Effect of Esculetin in an Experimental Animal Model of Inflammatory Bowel Disease
European Journal of Inflammation, 2013 Esculetin is a coumarin derivative with high antioxidant activity. In a rat experimental model of inflammatory bowel disease induced by trinitrobenzenesulfonic acid, esculetin at the dose of 5mg/Kg displayed intestinal anti-inflammatory activity; however,
A. Witaicenis +8 more
doaj +4 more sources
Umbelliferone and Esculetin: Inhibitors or Substrates for Polyphenol Oxidases? [PDF]
Biological and Pharmaceutical Bulletin, 2008 Recently, an interesting debate arose about the nature (substrate versus inhibitor) of esculetin, a coumarin derivative, for mushroom polyphenol oxidase (PPO). The present study examined the behavior of PPOs preparations from fungal and plant origin towards esculetin as a substrate. Both enzymes were able to oxidize esculetin though at a slow rate.
Sollai, F +4 more
openaire +4 more sources
Molecules, 2022 Esculetin is a coumarin-derived compound with antioxidant and anti-inflammatory properties. The current study aims to evaluate the therapeutic implications of esculetin on retinal dysfunction and uncover the underlying mechanisms.
Woo Kwon Jung +4 more
doaj +2 more sources
Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis
Rheumatology, 2016 Objectives : Esculetin (6,7-dihydroxycoumarin) is a natural coumarin with anti-oxidant, anti-inflammatory and anti-nociceptive activity. It acts as a potent inhibitor of lipoxygenases (5-LOX and 12-LOX) and decreases the production of matrix ...
Przemysław Rzodkiewicz +5 more
doaj +2 more sources