Results 11 to 20 of about 2,492 (169)

An NMR Study on Esculetin and It's Derivatives

open access: yesChinese Journal of Magnetic Resonance, 2019
The derivatives of esculetin contain hydroquinone groups that have various biological activities. In this study, the esculetin derivatives 2~14 were obtained by inducting the methoxy and hydroxyl groups into the 5, 6, 7 and 8 positions, and pheny group ...
LIU Ji-hong, JIN Kun, WANG Ping, LUO Gen
doaj   +2 more sources

Identification of Quality Markers in Viola kunawaresis Royel Using HPLC Fingerprints, Chemometric Analysis, and Network Pharmacology. [PDF]

open access: yesBiomed Chromatogr
ABSTRACT Violae tianshanicae herba (VTH), a widely used crude drug in Uyghur medicine in China, is renowned for its immunomodulatory, anti‐inflammatory, antibacterial, antiviral, and antidiabetic activities, with notable efficacy in treating asthma. However, systematic research on its quality markers (Q‐markers) remains limited, underscoring the need ...
Liu H   +6 more
europepmc   +2 more sources

Synergy, Additivity and Antagonism between Esculetin and Six Commonly Used Chemotherapeutics in Various Malignant Melanoma Cell Lines—An Isobolographic Analysis

open access: yesMolecules, 2023
(1) Malignant melanomas are dangerous skin cancers, and the treatment of melanomas with various cytostatic drugs often causes side effects and after their prolonged use resistance to these drugs appears.
Paula Wróblewska-Łuczka   +2 more
doaj   +1 more source

Pharmacological and Therapeutic Applications of Esculetin

open access: yesInternational Journal of Molecular Sciences, 2022
Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, etc. Free radicals lead to the development of oxidative stress causing inflammation, arthritis, cancer, diabetes, fatty liver disease, etc.
Sourbh Suren Garg   +3 more
openaire   +2 more sources

Antioxidant Efficacy of Esculetin against Tert-Butyl Hydroperoxide-Induced Oxidative Stress in HEK293 Cells

open access: yesCurrent Issues in Molecular Biology, 2022
Esculetin is an antioxidant and anti-inflammatory compound derived from coumarin. Oxidative stress can cause overproduction of reactive oxygen species (ROS), which can lead to the development of chronic kidney failure.
Woo Kwon Jung   +4 more
doaj   +1 more source

Examining the Antioxidant and Superoxide Radical Scavenging Activity of Anise, (Pimpinella anisum L. Seeds), Esculetin, and 4-Methyl-Esculetin Using X-ray Diffraction, Hydrodynamic Voltammetry and DFT Methods

open access: yesPharmaceuticals, 2023
Pimpinella anisum L., or anise, is a plant that, besides its nutritional value, has been used in traditional medical practices and described in many cultures in the Mediterranean region. A possible reason for anise’s therapeutic value is that it contains
Miriam Rossi   +7 more
doaj   +1 more source

The Coumarin-Derivative Esculetin Protects against Lipotoxicity in Primary Rat Hepatocytes via Attenuating JNK-Mediated Oxidative Stress and Attenuates Free Fatty Acid-Induced Lipid Accumulation

open access: yesAntioxidants, 2023
Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-associated fatty liver disease (MAFLD). However, the mechanisms underlying their beneficial effects remain unclear.
Mengmeng Xia   +4 more
doaj   +1 more source

Pharmacological activities of esculin and esculetin: A review

open access: yesMedicine, 2023
Esculin and esculetin are 2 widely studied coumarin components of Cortex Fraxini, which is a well-known herbal medicine with a 2000-year history. In vivo and in vitro studies have demonstrated that both have a variety of pharmacological activities, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, antidiabetic, immunomodulatory, anti-
Ting Cai, Bin Cai
openaire   +2 more sources

Esculetin as bioactive marker: towards a rational scientific approach for the treatment of hyperuricemia using Traditional Chinese Medicine

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2020
Traditional Chinese Herbal Medicine has been used to prevent and cure disease in China for thousands of years and has gained global interest in recent decades. The Erding formula is a Chinese Pharmacopeia (ChP)-listed herbal preparation used for treating
Jieyu Zuo   +4 more
doaj   +1 more source

Effect of Esculetin on Tert-Butyl Hydroperoxide-Induced Oxidative Injury in Retinal Pigment Epithelial Cells In Vitro

open access: yesMolecules, 2022
Esculetin is a coumarin-derived compound with antioxidant and anti-inflammatory properties. The current study aims to evaluate the therapeutic implications of esculetin on retinal dysfunction and uncover the underlying mechanisms.
Woo Kwon Jung   +4 more
doaj   +1 more source

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