Identification of Quality Markers in Viola kunawaresis Royel Using HPLC Fingerprints, Chemometric Analysis, and Network Pharmacology. [PDF]
Biomed ChromatogrABSTRACT Violae tianshanicae herba (VTH), a widely used crude drug in Uyghur medicine in China, is renowned for its immunomodulatory, anti‐inflammatory, antibacterial, antiviral, and antidiabetic activities, with notable efficacy in treating asthma. However, systematic research on its quality markers (Q‐markers) remains limited, underscoring the need ...
Liu H +6 more
europepmc +2 more sources
Cytotoxicity of Esculetin Compared with Vinblastine and Paclitaxel in PC-3 Prostate Cancer Cells [PDF]
Current OncologyBackground/Objectives: Metastatic prostate cancer is among the therapy-resistant human neoplasms. PC-3 is a commonly used experimental cell line that does not express androgen receptors.
Ana I. García-Pérez +4 more
doaj +2 more sources
Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review
Molecules, 2017 Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. The twig skin or trunk bark of Cortex Fraxini are used by herb doctors as a mild, bitter liver and gallbladder meridians ...
Chengyuan Liang
exaly +3 more sources
Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells
Frontiers in Immunology, 2018 Psoriasis is an autoimmune and inflammatory skin disease affecting around 2–3% of the world's population. Patients with psoriasis need extensive treatments with global immunosuppressive agents that may cause severe side effects.
Chuanjian Lu, Zhenhua Dai
exaly +3 more sources
Comparative Hepatoprotective Effects of Esculetin and Its Derivatives Against Oxidative Stress [PDF]
AntioxidantsIn this study, we evaluated the antioxidant activities of esculetin and four synthesized derivatives (E1, 2-oxo-2H-1-benzopyran-6,7-diyl diacetate; E2, 7-hydroxy-2-oxo-2H-1-benzopyran-6-yl acetate; E3, 7-(methoxymethoxy)-2-oxo-2H-1-benzopyran-6-yl ...
Yoonjeong Kim +4 more
doaj +2 more sources
The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition. [PDF]
New PhytolSummary Iron (Fe) is a transition metal necessary for achieving essential physiological processes throughout the plant lifecycle. In Arabidopsis thaliana, secreting Fe‐mobilizing coumarins (FMC) is a key mechanism enabling roots to acquire nonbioavailable Fe present in soils.
Watanabe S +7 more
europepmc +2 more sources
Esculetin inhibits ferroptosis after ICH by promoting NUDT1-mediated m7G methylation modification of GPX4 [PDF]
Scientific ReportsIntracerebral hemorrhage (ICH) is the most morbid of all stroke types with a high mortality and significant disability burden. Inhibiting ferroptosis after ICH will effectively treat ICH and improve prognosis.
Jinbing Gong +4 more
doaj +2 more sources
Esculetin attenuates cerebral ischemia-reperfusion injury and protects neurons through Nrf2 activation in rats [PDF]
Brazilian Journal of Medical and Biological ResearchNuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a key transcription factor in the antioxidant response and is associated with various chronic diseases.
Zhe Zhang +5 more
doaj +2 more sources
In silico evaluation of the anti Helicobacter pylori activity of selected bioactive compounds from Aloe vera [PDF]
Scientific ReportsHelicobacter pylori causes peptic ulcer, which is estimated to affect about half of the human population. Current treatments present with adverse side effects, and increasing antibiotic resistance have intensified the search for alternative therapeutic ...
Uwem Okon Edet +9 more
doaj +2 more sources
Esculetin inhibits the PI3K/Akt/mTOR pathway and enhances anti-colorectal cancer activity via binding to ENO1 [PDF]
Frontiers in PharmacologyIntroductionColorectal cancer (CRC) ranks as the third most prevalent malignant tumor worldwide and is the second leading cause of cancer-related mortality.
Jianing Ma +10 more
doaj +2 more sources