Effects of esculetin on growth performance, carcass traits, intestinal morphology, digestive enzyme, barrier function and cecal microbiota in broiler chickens [PDF]
Poultry ScienceThis study investigated the effects of dietary esculetin supplementation on growth performance, carcass traits, intestinal morphology, digestive enzymes, barrier function and cecal microbiota in broiler chickens.
Jingfei Zhang +5 more
doaj +2 more sources
Esculetin exhibits antifungal effects against Cryptococcus neoformans by inhibiting titan cell formation [PDF]
VirulenceCryptococcus neoformans is responsible for pulmonary cryptococcosis and life-threatening cryptococcal meningitis, particularly in immunocompromised individuals.
Xianwei Wu +7 more
doaj +2 more sources
Cytotoxicity of Esculetin Compared with Vinblastine and Paclitaxel in PC-3 Prostate Cancer Cells [PDF]
Current OncologyBackground/Objectives: Metastatic prostate cancer is among the therapy-resistant human neoplasms. PC-3 is a commonly used experimental cell line that does not express androgen receptors.
Ana I. García-Pérez +4 more
doaj +2 more sources
Bioactive Phenolic Acid Derivatives and Undescribed Esculetin Glycosides from Pseudopodospermum szowitzii (DC.) Kuth. [PDF]
MoleculesPseudopodospermum szowitzii (DC.) Kuth. a member of the Asteraceae family, grows naturally in the Irano-Turanian phytogeographical area, including Anatolia. In Anatolia, P. szowitsii, known as “goftigoda,” has edible young leaves and roots and is used in
Sezen Yılmaz Sarıaltın +3 more
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Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review
Molecules, 2017 Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. The twig skin or trunk bark of Cortex Fraxini are used by herb doctors as a mild, bitter liver and gallbladder meridians ...
Chengyuan Liang
exaly +3 more sources
Comparative Hepatoprotective Effects of Esculetin and Its Derivatives Against Oxidative Stress [PDF]
AntioxidantsIn this study, we evaluated the antioxidant activities of esculetin and four synthesized derivatives (E1, 2-oxo-2H-1-benzopyran-6,7-diyl diacetate; E2, 7-hydroxy-2-oxo-2H-1-benzopyran-6-yl acetate; E3, 7-(methoxymethoxy)-2-oxo-2H-1-benzopyran-6-yl ...
Yoonjeong Kim +4 more
doaj +2 more sources
Esculetin inhibits ferroptosis after ICH by promoting NUDT1-mediated m7G methylation modification of GPX4 [PDF]
Scientific ReportsIntracerebral hemorrhage (ICH) is the most morbid of all stroke types with a high mortality and significant disability burden. Inhibiting ferroptosis after ICH will effectively treat ICH and improve prognosis.
Jinbing Gong +4 more
doaj +2 more sources
Esculetin attenuates cerebral ischemia-reperfusion injury and protects neurons through Nrf2 activation in rats [PDF]
Brazilian Journal of Medical and Biological ResearchNuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a key transcription factor in the antioxidant response and is associated with various chronic diseases.
Zhe Zhang +5 more
doaj +2 more sources
Esculetin inhibits the PI3K/Akt/mTOR pathway and enhances anti-colorectal cancer activity via binding to ENO1 [PDF]
Frontiers in PharmacologyIntroductionColorectal cancer (CRC) ranks as the third most prevalent malignant tumor worldwide and is the second leading cause of cancer-related mortality.
Jianing Ma +10 more
doaj +2 more sources
Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway [PDF]
Brazilian Journal of Medical and Biological Research, 2015 This study investigated the in vitro and in vivo antiproliferative activity of esculetin against hepatocellular carcinoma, and clarified its potential molecular mechanisms. Cell viability was determined by the MTT (tetrazolium) colorimetric assay.
J. Wang +5 more
doaj +3 more sources