Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review
Molecules, 2017 Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. The twig skin or trunk bark of Cortex Fraxini are used by herb doctors as a mild, bitter liver and gallbladder meridians ...
Chengyuan Liang, Yonghong Tang
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Cytotoxicity of Esculetin Compared with Vinblastine and Paclitaxel in PC-3 Prostate Cancer Cells [PDF]
Current OncologyBackground/Objectives: Metastatic prostate cancer is among the therapy-resistant human neoplasms. PC-3 is a commonly used experimental cell line that does not express androgen receptors.
Ana I. García-Pérez +4 more
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Comparative Hepatoprotective Effects of Esculetin and Its Derivatives Against Oxidative Stress [PDF]
AntioxidantsIn this study, we evaluated the antioxidant activities of esculetin and four synthesized derivatives (E1, 2-oxo-2H-1-benzopyran-6,7-diyl diacetate; E2, 7-hydroxy-2-oxo-2H-1-benzopyran-6-yl acetate; E3, 7-(methoxymethoxy)-2-oxo-2H-1-benzopyran-6-yl ...
Yoonjeong Kim +4 more
doaj +3 more sources
Esculetin inhibits ferroptosis after ICH by promoting NUDT1-mediated m7G methylation modification of GPX4 [PDF]
Scientific ReportsIntracerebral hemorrhage (ICH) is the most morbid of all stroke types with a high mortality and significant disability burden. Inhibiting ferroptosis after ICH will effectively treat ICH and improve prognosis.
Jinbing Gong +4 more
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Effects of esculetin on growth performance, carcass traits, intestinal morphology, digestive enzyme, barrier function and cecal microbiota in broiler chickens [PDF]
Poultry ScienceThis study investigated the effects of dietary esculetin supplementation on growth performance, carcass traits, intestinal morphology, digestive enzymes, barrier function and cecal microbiota in broiler chickens.
Jingfei Zhang +5 more
doaj +2 more sources
Esculetin exhibits antifungal effects against Cryptococcus neoformans by inhibiting titan cell formation [PDF]
VirulenceCryptococcus neoformans is responsible for pulmonary cryptococcosis and life-threatening cryptococcal meningitis, particularly in immunocompromised individuals.
Xianwei Wu +7 more
doaj +2 more sources
Bioactive Phenolic Acid Derivatives and Undescribed Esculetin Glycosides from Pseudopodospermum szowitzii (DC.) Kuth. [PDF]
MoleculesPseudopodospermum szowitzii (DC.) Kuth. a member of the Asteraceae family, grows naturally in the Irano-Turanian phytogeographical area, including Anatolia. In Anatolia, P. szowitsii, known as “goftigoda,” has edible young leaves and roots and is used in
Sezen Yılmaz Sarıaltın +3 more
doaj +2 more sources
Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells
Frontiers in Immunology, 2018 Psoriasis is an autoimmune and inflammatory skin disease affecting around 2–3% of the world's population. Patients with psoriasis need extensive treatments with global immunosuppressive agents that may cause severe side effects.
Yuchao Chen +2 more
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Inhibition of Quorum Sensing and Biofilm Formation of Esculetin on Aeromonas Hydrophila [PDF]
Frontiers in Microbiology, 2021 Quorum sensing (QS) and biofilm formation inhibition activity of esculetin on Aeromonas hydrophila SHAe 115 were evaluated. Exposure to esculetin at 25, 50, and 100μg/ml significantly inhibited the production of protease and hemolysin, the formation of ...
Bing Sun +5 more
doaj +3 more sources
Esculetin Improves LPS/D-GalN Induced Acute Liver Injury Through AMPK/SIRT1/PGC-1α Signaling Pathway [PDF]
AntioxidantsThe pathogenesis of acute liver injury (ALI) involves the loss of hepatic detoxification function, massive death of liver parenchymal cells within a short period, and excessive inflammatory responses.
Haoyang Dai +3 more
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