Results 61 to 70 of about 2,995 (191)
Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli
Molecules, 2022 Coumarins and furanocoumarins are plant secondary metabolites with known biological activities. As they are present in low amounts in plants, their heterologous production emerged as a more sustainable and efficient approach to plant extraction. Although
Joana L. Rodrigues +2 more
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Kinetic Characterization of the Oxidation of Esculetin by Polyphenol Oxidase and Peroxidase
Bioscience, Biotechnology, and Biochemistry, 2007 Esculetin has been described as an inhibitor of tyrosinase and polyphenol oxidase and, therefore, of melanogenesis. In this work, we demonstrate that esculetin is not an inhibitor but a substrate of mushroom polyphenol oxidase (PPO) and horseradish peroxidase (POD), enzymes which oxidize esculetin, generating its o-quinone.
MUNOZ-MUNOZ, Joseph Louis +5 more
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Mechanistic insights into the biochemical and pharmacological profile of esculetin
, 2022 Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, and many others. Glycosides and caffeic acid conjugates are the common forms of esculetin present in medicinal plants.
Sourbh Suren Garg +3 more
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Advanced Science, Volume 13, Issue 13, 3 March 2026.A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong +11 more
wiley +1 more source
From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery
Biopolymers, Volume 117, Issue 2, March 2026.ABSTRACT Polymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient encapsulation of both hydrophilic and lipophilic drugs, making them promising for drug delivery.
Milena Ferreira de Lima +8 more
wiley +1 more source
Spectrophotometric Studies of Ferric-esculetin Complex
, 1963 Esculatin (6,7-dihydroxycoumarin) hes boon found to form soluble, coloured complexes at different pH with ferric ions. At pH 9.5 end 394m\(\mu\), the complex in 25% methanolic solution obeys Beer's law up to 1.8 p.p.m. of iron (III). Job's method of continued variation and electrophoretio studies have been used to suggest a tentative structure.
B. D. Jain, H. B. Singh
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Protective effect of Esculetin on myocardial injury induced by doxorubicin
Nepalese Journal of Cancer, 2022 Objective: To study the protective effect of Esculetin on myocardial injury induced by doxorubicin and explore the mechanism of doxorubicin on myocardial injury in rats. Methods: Doxorubicin(2.5mg/kg) was injected intraperitoneally every other day for 6 times to establish a rat model of myocardial injury.
Fan Xu, Xiao Li, Xiaolei Yu
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Food Frontiers, Volume 7, Issue 2, March 2026.ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani +3 more
wiley +1 more source
Journal of Hepatocellular Carcinoma, 2023 Zhiru Xiu,1 Yiquan Li,1 Jinbo Fang,1 Jicheng Han,1 Shanzhi Li,1 Yaru Li,1,2 Xia Yang,1 Gaojie Song,3 Yue Li,1 Ningyi Jin,1,4,5 Yilong Zhu,1 Guangze Zhu,1 Lili Sun,6 Xiao Li1,4,7 1Academician Workstation of Jilin Province, Changchun University of Chinese ...
Xiu Z +13 more
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New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov +16 more
wiley +1 more source