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The possible anti-tumor actions and mechanisms of active metabolites from Cortex Fraxini. [PDF]

Front Pharmacol
Cai B, Cai T, Feng Z, Zhu H.
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Esculetin: A review of its pharmacology and pharmacokinetics

Phytotherapy Research, 2021
AbstractEsculetin is a natural dihydroxy coumarin; it is mainly extracted from twig skin and the trunk bark of the Chinese herbal medicineFraxinus rhynchophyllaHance. Emerging evidence suggests that esculetin has a wide range of pharmacological activities.
Linlin Zhang, Qingxuan Xie, Xiaofang Li
openaire   +2 more sources

Umbelliferone and Esculetin: Inhibitors or Substrates for Polyphenol Oxidases?

Biological and Pharmaceutical Bulletin, 2008
Recently, an interesting debate arose about the nature (substrate versus inhibitor) of esculetin, a coumarin derivative, for mushroom polyphenol oxidase (PPO). The present study examined the behavior of PPOs preparations from fungal and plant origin towards esculetin as a substrate. Both enzymes were able to oxidize esculetin though at a slow rate.
Antonio Rescigno, Paolo Zucca, Enrico Sanjust   +2 more
exaly   +4 more sources

Selective inhibition of platelet lipoxygenase by esculetin

Lipids and Lipid Metabolism, 1982
The effects of coumarin and its derivatives on rat platelet lipoxygenase and cyclooxygenase activities were studied. Esculetin (6,7-dihydroxycoumarin) was found to inhibit the lipoxygenase more strongly than the cyclooxygenase; its concentration for 50% inhibition (IC50) was 0.65 microM for platelet lipoxygenase and 0.45 mM for platelet cyclooxygenase.
Okuda Hiromichi
exaly   +3 more sources

Induction of apoptosis by esculetin in human leukemia cells

European Journal of Pharmacology, 2001
Esculetin, a coumarin compound, has been shown to exhibit antioxidant and anti-inflammatory effects. In the present study, esculetin was found to inhibit the survival of human promyelocytic leukemia HL-60 cells in a concentration-dependent and time-dependent manner.
Tsui-Hwa Tseng, Chau-Jong Wang, Chia-Yih Chu   +2 more
exaly   +3 more sources

The In Vivo Effect of Esculetin Ointment and Esculetin-Mixed Zyderm for Zyderm

Plastic and Reconstructive Surgery, 2014
Injectable collagen is often used for treatment of wrinkles or scars in cosmetic surgery. However, it is degraded within a short period after subcutaneous injection. The authors aimed to achieve a long-lasting effect of the filler with a new collagenase inhibitor, esculetin (6,7-dihydroxy-2H-chromen-2-one).Nude mice were divided into two study groups ...
Hisayo, Yamaoka, Satoru, Nishizawa, Masateru, Matsui, Koichi, Gonda, Shinichi, Hirabayashi, Kazuto, Hoshi, Keiko, Yamaoka   +6 more
openaire   +2 more sources

Microdetermination of esculetin in Nicotiana tabacum

Analytical Biochemistry, 1973
Abstract A glc method has been described for the quantitative analysis of tobacco (and other plant tissue) for esculetin (as free esculetin and the glucosides esculin or cichoriin) which used tritium-foil electron-capture detection of as little as 15 ng esculetin.
T H, Vaughn, R A, Andersen
openaire   +2 more sources

ESCULETIN PREVENTS LIVER DAMAGE INDUCED BY PARACETAMOL AND CCL4

Pharmacological Research, 1998
Esculetin, a phenolic compound found in Cichorium intybus and Bougainvllra spectabillis was investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. Paracetamol produced 100% mortality at the dose of 1 g kg-1 in mice while pre-treatment of animals with esculetin (6 mg kg-1) reduced the death rate to 40%. Oral
Khalid Hussain Janbaz, B H Shāh, A H Gilani   +2 more
exaly   +3 more sources

Anti-inflammatory and peripheral analgesic activity of esculetin in vivo

Pharmacological Research Communications, 1988
Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.
Paola Del Negro, R Della Loggia
exaly   +5 more sources

Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis

Lipids and Lipid Metabolism, 1983
Esculetin (6,7-dihydroxycoumarin) showed inhibitory effects on 5- and 12-lipoxygenases of cloned mastocytoma cells. The half-inhibition dose (ID50) for each enzyme was 4 X 10(-6) and 2.5 X 10(-6) M, respectively. No inhibition at all, but rather a stimulating effect on prostaglandin synthesis, was observed, especially at higher doses of esculetin ...
T, Neichi, Y, Koshihara, S, Murota
exaly   +3 more sources